Hfe effect on hepcidin production (WP3673)

Mus musculus

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Hfe, the mouse equivalent of the human hemochromatosis gene, is known to promote expression of hepcidin, a gene product that inhibits iron absorption, but it is not fully clear how it does this, or at which point Hfe interacts with the cycle(Hfe could be acting on the interaction at points A,B, or C). Hfe, as well as Tmprss6, another gene product, are used in the regulation of systemic iron homeostasis. Evidence obtained from gene testing on mice seems to indicate that Hfe inhibits Tmprss6, which is known to be an inhibitor of Hjv, a gene product that augments BMP/SMAD signaling for the production of hepcidin. Alternatively, Hfe may promote Bmp/Smad signaling by HJV, or by promoting signaling at a point past where Tmprss6 inhibits HJV.

Authors

AAR&Co , Alex Pico , Martina Summer-Kutmon , and Kristina Hanspers

Activity

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

regulatory pathway iron homeostasis pathway

Participants

Label Type Compact URI Comment
Hfe GeneProduct ensembl:ENSMUSG00000006611
Tmprss6 GeneProduct ensembl:ENSMUSG00000016942
Hfe2 GeneProduct ensembl:ENSMUSG00000038403
Hamp GeneProduct ensembl:ENSMUSG00000050440 Hepcidin. Inhibits iron absorbtion
Bmp6 GeneProduct ensembl:ENSMUSG00000039004
Smad7 GeneProduct ensembl:ENSMUSG00000025880
Id1 GeneProduct ensembl:ENSMUSG00000042745

References

  1. Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice. Finberg KE, Whittlesey RL, Andrews NC. Blood. 2011 Apr 28;117(17):4590–9. PubMed Europe PMC Scholia