MicroRNAs in cardiomyocyte hypertrophy (WP1560)

Mus musculus

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This pathway shows the role of microRNAs in the process of cardiac hypertrophy. Converted from the humane pathway. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted interactions are shown in red, dashed lines. MicroRNAs are shown as purple rounded rectangles. It is not sure which WNT and frizzled proteins influence cardiac hypertrophy. Though there are strong indications that WNT3A, WNT5A, frizzled1 and frizzled2 play a role in cardiac hypertrophy. Thus these have been added to the pathway instead of all the WNT and frizzled proteins. Experiments which will shed light on this are still being done.

Authors

Maartje Levels , Daniela Digles , Alex Pico , Laurent Winckers , and Eric Weitz

Activity

last edited

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

hypertrophic cardiomyopathy pathway

Participants

Label Type Compact URI Comment
Calcium Metabolite hmdb:HMDB0000464
Calcium Metabolite hmdb:HMDB0000464
Cyclic GMP Metabolite hmdb:HMDB0001314
Calcium Metabolite hmdb:HMDB0000464
IP3 Metabolite hmdb:HMDB0001498
DAG Metabolite hmdb:HMDB0007009
Wnt3a GeneProduct ncbigene:22416
Stat3 GeneProduct ncbigene:20848
Mapk3 GeneProduct ncbigene:26417
Lif GeneProduct ncbigene:16878
Lrp5 GeneProduct ncbigene:16973
Mylk3 GeneProduct ncbigene:213435
Rcan1 GeneProduct ncbigene:54720
Prkcb GeneProduct ncbigene:18751
Prkcb GeneProduct ncbigene:18751
Mapk3 GeneProduct ncbigene:26417
Rac1 GeneProduct ncbigene:19353
Hdac4 GeneProduct ncbigene:208727
Hdac9 GeneProduct ncbigene:79221
Pdpk1 GeneProduct ncbigene:18607
Igf1 GeneProduct ncbigene:16000
Mapk8 GeneProduct ncbigene:26419
Mapk1 GeneProduct ncbigene:26413
Chuk GeneProduct ncbigene:12675
Cdk7 GeneProduct ncbigene:12572
Ctnnb1 GeneProduct ncbigene:12387
Ikbkg GeneProduct ncbigene:16151
Agt GeneProduct ncbigene:11606
Dvl1 GeneProduct ncbigene:13542
Nfatc4 GeneProduct ncbigene:73181
Gsk3b GeneProduct ncbigene:56637
Mapk7 GeneProduct ncbigene:23939
Pik3ca GeneProduct ncbigene:18706
Ctf1 GeneProduct ncbigene:13019
Map2k2 GeneProduct ncbigene:26396
Pik3r1 GeneProduct ncbigene:18708
Mapk3 GeneProduct ncbigene:26417
Pik3r2 GeneProduct ncbigene:18709
Map2k4 GeneProduct ncbigene:26398
Nfkb1 GeneProduct ncbigene:18033
Igf1r GeneProduct ncbigene:16001
Map3k14 GeneProduct ncbigene:53859
Hdac7 GeneProduct ncbigene:56233
Cish GeneProduct ncbigene:12700
Nfatc4 GeneProduct ncbigene:73181
Hdac4 GeneProduct ncbigene:208727
Nfatc4 GeneProduct ncbigene:73181
Mapk1 GeneProduct ncbigene:26413
Rock1 GeneProduct ncbigene:19877
Pdpk1 GeneProduct ncbigene:18607
Cdk9 GeneProduct ncbigene:107951
Prkg1 GeneProduct ncbigene:19091
Pik3cd GeneProduct ncbigene:18707
Plcb2 GeneProduct ncbigene:18796
Ikbke GeneProduct ncbigene:56489
Mapk14 GeneProduct ncbigene:26416
Fgfr2 GeneProduct ncbigene:14183
Mapk3 GeneProduct ncbigene:26417
Mylk GeneProduct ncbigene:107589
Raf1 GeneProduct ncbigene:110157
Edn1 GeneProduct ncbigene:13614
Hdac9 GeneProduct ncbigene:79221
Ikbkb GeneProduct ncbigene:16150
Hdac7 GeneProduct ncbigene:56233
Il6st GeneProduct ncbigene:16195
Fzd2 GeneProduct ncbigene:57265
Lrp6 GeneProduct ncbigene:16974
Map2k7 GeneProduct ncbigene:26400
Pik3cb GeneProduct ncbigene:74769
Gsk3b GeneProduct ncbigene:56637
Pik3r3 GeneProduct ncbigene:18710
Nrg1 GeneProduct ncbigene:211323
Egf GeneProduct ncbigene:13645
Myef2 GeneProduct ncbigene:17876
Mapk8 GeneProduct ncbigene:26419
Ppp3cb GeneProduct ncbigene:19056
Akt2 GeneProduct ncbigene:11652
Tgfb1 GeneProduct ncbigene:21803
Mtor GeneProduct ncbigene:56717
Fgf2 GeneProduct ncbigene:14173
Map2k3 GeneProduct ncbigene:26397
Agt GeneProduct ncbigene:11606
Mapk4 GeneProduct ncbigene:225724
Map2k5 GeneProduct ncbigene:23938
Nppa GeneProduct ncbigene:230899
Mapk3 GeneProduct ncbigene:26417
sPla2-IIA GeneProduct ncbigene:18780
Pik3cg GeneProduct ncbigene:30955
Stat3 GeneProduct ncbigene:20848
Tnf GeneProduct ncbigene:21926
Rock2 GeneProduct ncbigene:19878
Mapk14 GeneProduct ncbigene:26416
Map2k1 GeneProduct ncbigene:26395
Nppb GeneProduct ncbigene:18158
Hdac5 GeneProduct ncbigene:15184
Rhoa GeneProduct ncbigene:11848
Wnt5a GeneProduct ncbigene:22418
Gata4 GeneProduct ncbigene:14463
Eif2b5 GeneProduct ncbigene:224045
Akt1 GeneProduct ncbigene:11651
Ppp3ca GeneProduct ncbigene:19055
Camk2d GeneProduct ncbigene:108058
Map3k7ip1 GeneProduct ncbigene:66513
Map2k6 GeneProduct ncbigene:26399
Fzd1 GeneProduct ncbigene:14362
Hdac5 GeneProduct ncbigene:15184
Nfkb1 GeneProduct ncbigene:18033
CaM Protein ncbigene:12313

References

  1. Calcineurin and human heart failure. Lim HW, Molkentin JD. Nat Med. 1999 Mar;5(3):246–7. PubMed Europe PMC Scholia
  2. The PI3K-PDK1 connection: more than just a road to PKB. Vanhaesebroeck B, Alessi DR. Biochem J. 2000 Mar 15;346 Pt 3(Pt 3):561–76. PubMed Europe PMC Scholia
  3. Regulation of cardiac hypertrophy by intracellular signalling pathways. Heineke J, Molkentin JD. Nat Rev Mol Cell Biol. 2006 Aug;7(8):589–600. PubMed Europe PMC Scholia
  4. MicroRNA-133 controls cardiac hypertrophy. Carè A, Catalucci D, Felicetti F, Bonci D, Addario A, Gallo P, et al. Nat Med. 2007 May;13(5):613–8. PubMed Europe PMC Scholia
  5. The Wnt/frizzled/GSK-3 beta pathway: a novel therapeutic target for cardiac hypertrophy. Blankesteijn WM, van de Schans VAM, ter Horst P, Smits JFM. Trends Pharmacol Sci. 2008 Apr;29(4):175–80. PubMed Europe PMC Scholia
  6. MicroRNA: novel regulators involved in the remodeling and reverse remodeling of the heart. Wang J, Xu R, Lin F, Zhang S, Zhang G, Hu S, et al. Cardiology. 2009;113(2):81–8. PubMed Europe PMC Scholia
  7. STAT3 and cardiac remodeling. Haghikia A, Stapel B, Hoch M, Hilfiker-Kleiner D. Heart Fail Rev. 2011 Jan;16(1):35–47. PubMed Europe PMC Scholia