Type II interferon signaling (IFNG) (WP1253)
Mus musculus
Adapted from Raza et al. (2008). This pathway is initiated by IFNG binding to its receptor and a subsequent phosphorylation cascade involving a number of the JAK and STAT family of proteins. Several transcriptionally active complexes are formed (STAT1 homodimer, ISGF3 complex, STAT1:STAT1:IRF9 complex) and the pathway culminates with the transcriptional activation of target genes. [1]
Authors
De-Cheng Chao , Alex Pico , Kristina Hanspers , Daniela Digles , and Martina Summer-KutmonActivity
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Cited In
- Reduced tumor growth in EP2 knockout mice is related to signaling pathways favoring an increased local anti-tumor immunity in the tumor stroma (2022).
- Post-weaning epiphysiolysis causes distal femur dysplasia and foreshortened hindlimbs in fetuin-A-deficient mice (2017).
- Comparative Screening of the Liver Gene Expression Profiles from Type 1 and Type 2 Diabetes Rat Models (2024).
- Proteomic profiling of salivary gland after nonviral gene transfer mediated by conventional plasmids and minicircles (2014).
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Organisms
Mus musculusCommunities
Annotations
Pathway Ontology
type II interferon signaling pathwayCell Type Ontology
macrophage| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Ifng | GeneProduct | ncbigene:15978 | |
| Ifngr1 | GeneProduct | ncbigene:15979 | |
| Ifngr2 | GeneProduct | ncbigene:15980 | |
| Jak1 | GeneProduct | ncbigene:16451 | |
| Jak2 | GeneProduct | ncbigene:16452 | |
| Socs3 | GeneProduct | ncbigene:12702 | |
| Socs1 | GeneProduct | ncbigene:12703 | |
| Ptpn11 | GeneProduct | ncbigene:19247 | |
| Stat1 | GeneProduct | ncbigene:20846 | |
| Stat2 | GeneProduct | ncbigene:20847 | |
| Irf9 | GeneProduct | ncbigene:16391 | |
| Prkcd | GeneProduct | ncbigene:18753 | |
| Reg1 | GeneProduct | ncbigene:19692 | |
| Irf4 | GeneProduct | ncbigene:16364 | |
| Sfpi1 | GeneProduct | ncbigene:20375 | |
| IFNA | GeneProduct | ncbigene:111654 | |
| Ifnb1 | GeneProduct | ncbigene:15977 | |
| Nos2 | GeneProduct | ncbigene:18126 | |
| GBP1 | GeneProduct | ncbigene:14468 | |
| HIST2H4 | GeneProduct | ncbigene:97122 | |
| Psmb9 | GeneProduct | ncbigene:16912 | |
| Tap1 | GeneProduct | ncbigene:21354 | |
| Cxcl10 | GeneProduct | ncbigene:15945 | |
| Ciita | GeneProduct | ncbigene:12265 | |
| Cybb | GeneProduct | ncbigene:13058 | |
| Il1b | GeneProduct | ncbigene:16176 | |
| Ifit2 | GeneProduct | ncbigene:15958 | |
| Eif2ak2 | GeneProduct | ncbigene:19106 | |
| Irf1 | GeneProduct | ncbigene:16362 | |
| Icam1 | GeneProduct | ncbigene:15894 | |
| Cxcl9 | GeneProduct | ncbigene:17329 | |
| Isg15 | GeneProduct | ncbigene:100038882 | |
| Irf8 | GeneProduct | ncbigene:15900 | |
| Irf2 | GeneProduct | ncbigene:16363 |
References
- A logic-based diagram of signalling pathways central to macrophage activation. Raza S, Robertson KA, Lacaze PA, Page D, Enright AJ, Ghazal P, et al. BMC Syst Biol. 2008 Apr 23;2:36. PubMed Europe PMC Scholia