Welcome to the CPTAC Community at WikiPathways!
The CPTAC Community highlights pathway content relevant to the Clinical Proteomic Tumor Analysis Consortium (CPTAC). CPTAC is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of robust, quantitative, proteomic technologies and workflows. The pathways in this portal include comprehensive cancer-type specific models for several of the CPTAC cancer types, pathways describing processes affected in specific cancer types as well as many pathways describing normal biological processes that are known to be important in cancer biology. The CPTAC pathways at WikiPathways have been organized into classic cancer hallmark categories, based on the different biological capabilities acquired during the multistep development of human tumors.
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Cancer Hallmark Categories
Community Pathways
Table FiltersThis community helps to curate 112 pathways:
- 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression - WP3879 (Homo sapiens)
- ATM signaling - WP2516 (Homo sapiens)
- ATM signaling in development and disease - WP3878 (Homo sapiens)
- ATR signaling - WP3875 (Homo sapiens)
- Altered glycosylation of MUC1 in tumor microenvironment - WP4480 (Homo sapiens)
- Amino acid metabolism in triple-negative breast cancer cells - WP5213 (Homo sapiens)
- Androgen receptor network in prostate cancer - WP2263 (Homo sapiens)
- Angiogenesis - WP1539 (Homo sapiens)
- Apoptosis - WP254 (Homo sapiens)
- Autophagy in pancreatic ductal adenocarcinoma - WP5331 (Homo sapiens)
- Base excision repair - WP4752 (Homo sapiens)
- Bladder cancer - WP2828 (Homo sapiens)
- Breast cancer pathway - WP4262 (Homo sapiens)
- CCL18 signaling - WP5097 (Homo sapiens)
- Cancer immunotherapy by CTLA4 blockade - WP4582 (Homo sapiens)
- Cancer immunotherapy by PD-1 blockade - WP4585 (Homo sapiens)
- Cancer pathways - WP5434 (Homo sapiens)
- Cell cycle - WP179 (Homo sapiens)
- Chemokine signaling - WP3929 (Homo sapiens)
- Chromosomal and microsatellite instability in colorectal cancer - WP4216 (Homo sapiens)
- Clear cell renal cell carcinoma pathways - WP4018 (Homo sapiens)
- Cytokines and inflammatory response - WP530 (Homo sapiens)
- Cytosolic DNA-sensing pathway - WP4655 (Homo sapiens)
- DNA IR-damage and cellular response via ATR - WP4016 (Homo sapiens)
- DNA IR-double strand breaks and cellular response via ATM - WP3959 (Homo sapiens)
- DNA damage response - WP707 (Homo sapiens)
- DNA damage response (only ATM dependent) - WP710 (Homo sapiens)
- DNA mismatch repair - WP531 (Homo sapiens)
- Direct reversal repair - WP4931 (Homo sapiens)
- EGFR tyrosine kinase inhibitor resistance - WP4806 (Homo sapiens)
- EPO receptor signaling - WP581 (Homo sapiens)
- Endometrial cancer - WP4155 (Homo sapiens)
- Epithelial to mesenchymal transition in colorectal cancer - WP4239 (Homo sapiens)
- ErbB signaling - WP673 (Homo sapiens)
- FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma - WP4553 (Homo sapiens)
- Fatty acid beta-oxidation - WP143 (Homo sapiens)
- Fluoropyrimidine activity - WP1601 (Homo sapiens)
- Focal adhesion: PI3K-Akt-mTOR-signaling - WP3932 (Homo sapiens)
- G1 to S cell cycle control - WP45 (Homo sapiens)
- Glycolysis and gluconeogenesis - WP534 (Homo sapiens)
- H19, Rb-E2F1, and CDK-beta-catenin in colorectal cancer - WP3969 (Homo sapiens)
- Head and neck squamous cell carcinoma - WP4674 (Homo sapiens)
- Hedgehog signaling - WP4249 (Homo sapiens)
- Hepatitis B infection - WP4666 (Homo sapiens)
- Hepatitis C and hepatocellular carcinoma - WP3646 (Homo sapiens)
- Hepatocyte growth factor receptor signaling - WP313 (Homo sapiens)
- Hereditary leiomyomatosis and renal cell carcinoma pathway - WP4206 (Homo sapiens)
- Hippo-Merlin signaling dysregulation - WP4541 (Homo sapiens)
- IL1 signaling - WP195 (Homo sapiens)
- IL6 signaling - WP364 (Homo sapiens)
- Imatinib and chronic myeloid leukemia - WP3640 (Homo sapiens)
- Immune infiltration in pancreatic cancer - WP5285 (Homo sapiens)
- Inhibition of exosome biogenesis and secretion by Manumycin A in CRPC cells - WP4301 (Homo sapiens)
- Integrin-mediated cell adhesion - WP185 (Homo sapiens)
- Interactions between immune cells and microRNAs in tumor microenvironment - WP4559 (Homo sapiens)
- Interferon type I signaling - WP585 (Homo sapiens)
- Irinotecan pathway - WP229 (Homo sapiens)
- MAPK signaling - WP382 (Homo sapiens)
- MET in type 1 papillary renal cell carcinoma - WP4205 (Homo sapiens)
- MFAP5 effect on permeability and motility of endothelial cells via cytoskeleton rearrangement - WP4560 (Homo sapiens)
- MFAP5-mediated ovarian cancer cell motility and invasiveness - WP3301 (Homo sapiens)
- Measles virus infection - WP4630 (Homo sapiens)
- Melanoma - WP4685 (Homo sapiens)
- Metabolic reprogramming in colon cancer - WP4290 (Homo sapiens)
- Metabolic reprogramming in pancreatic cancer - WP5220 (Homo sapiens)
- Methylation pathways - WP704 (Homo sapiens)
- MicroRNA for targeting cancer growth and vascularization in glioblastoma - WP3593 (Homo sapiens)
- Model for regulation of MSMP expression in cancer cells and its proangiogenic role in ovarian tumors - WP4397 (Homo sapiens)
- NRF2-ARE regulation - WP4357 (Homo sapiens)
- NRP1-triggered signaling in pancreatic cancer - WP5144 (Homo sapiens)
- Neural crest cell migration in cancer - WP4565 (Homo sapiens)
- Non-homologous end joining - WP438 (Homo sapiens)
- Non-small cell lung cancer - WP4255 (Homo sapiens)
- Notch signaling - WP268 (Homo sapiens)
- Notch signaling - WP61 (Homo sapiens)
- Nucleotide excision repair - WP4753 (Homo sapiens)
- One-carbon metabolism - WP241 (Homo sapiens)
- PDGF pathway - WP2526 (Homo sapiens)
- PDGFR-beta pathway - WP3972 (Homo sapiens)
- PI3K-AKT-mTOR signaling and therapeutic opportunities in prostate cancer - WP3844 (Homo sapiens)
- Pancreatic adenocarcinoma pathway - WP4263 (Homo sapiens)
- Photodynamic therapy-induced HIF-1 survival signaling - WP3614 (Homo sapiens)
- Photodynamic therapy-induced NF-kB survival signaling - WP3617 (Homo sapiens)
- Pleural mesothelioma - WP5087 (Homo sapiens)
- Ras signaling - WP4223 (Homo sapiens)
- Regulation of Wnt / B-catenin signaling by small molecule compounds - WP3664 (Homo sapiens)
- Regulation of sister chromatid separation at the metaphase-anaphase transition - WP4240 (Homo sapiens)
- Retinoblastoma gene in cancer - WP2446 (Homo sapiens)
- Small cell lung cancer - WP4658 (Homo sapiens)
- TCA cycle nutrient use and invasiveness of ovarian cancer - WP2868 (Homo sapiens)
- TGF-beta receptor signaling - WP560 (Homo sapiens)
- TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition - WP3859 (Homo sapiens)
- TGF-beta signaling pathway - WP366 (Homo sapiens)
- TP53 network - WP1742 (Homo sapiens)
- Target of rapamycin signaling - WP1471 (Homo sapiens)
- Transcriptional activation by NRF2 in response to phytochemicals - WP3 (Homo sapiens)
- Translation inhibitors in chronically activated PDGFRA cells - WP4566 (Homo sapiens)
- Tumor suppressor activity of SMARCB1 - WP4204 (Homo sapiens)
- Type 2 papillary renal cell carcinoma - WP4241 (Homo sapiens)
- Type II interferon signaling - WP619 (Homo sapiens)
- Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer - WP4284 (Homo sapiens)
- VEGFA-VEGFR2 signaling - WP3888 (Homo sapiens)
- Warburg effect modulated by deubiquitinating enzymes and their substrates - WP5216 (Homo sapiens)
- Wnt signaling - WP363 (Homo sapiens)
- Wnt signaling - WP428 (Homo sapiens)
- Wnt/beta-catenin signaling in leukemia - WP3658 (Homo sapiens)
- lncRNA in canonical Wnt signaling and colorectal cancer - WP4258 (Homo sapiens)
- lncRNA-mediated mechanisms of therapeutic resistance - WP3672 (Homo sapiens)
- miRNA regulation of p53 pathway in prostate cancer - WP3982 (Homo sapiens)
- miRNA regulation of prostate cancer signaling - WP3981 (Homo sapiens)
- ncRNAs in Wnt signaling in hepatocellular carcinoma - WP4336 (Homo sapiens)
- ncRNAs involved in STAT3 signaling in hepatocellular carcinoma - WP4337 (Homo sapiens)
How to Contribute
The CPTAC set of pathways can be edited, updated and added to by anyone with a WikiPathways account.
Support
This work is supported by The National Cancer Institute.
Community Members
Alex Pico and Kristina Hanspers .
Authors of Community Pathways
Alex Pico , Kristina Hanspers , AAR&Co , Egon Willighagen , Andika Tan , Anders Riutta , Friederike Ehrhart , Eric Weitz , Arturo Manzo-Fontes P D , Martina Summer-Kutmon , Zahra Roudbari , Laurent Winckers , Andra Waagmeester , Phillip Febbo , Robertbaertsch , Daniela Digles , Lauren J. Dupuis , Laur S , James Bjork , Martijn Van Iersel , Marianthi Kalafati , Alexander C. Zambon , Thomas Kelder , Susan Coort , Angelika , Beth Lawlor , Marc Gillespie , Jildau Bouwman , Nuno , Josip , Anam , Ncananfiliz , Isabel Wassink , Denise Slenter , Finterly Hu , Lars Willighagen , Oneshin , Irene Hemel , Dr. T. S. Keshava Prasad , Nathan Salomonis , Iliana Campillo Sach , Bruce Conklin , Sergey Dmitriev , Badrul Yahaya , Christine Chichester , Sebastien Burel , Ferry Jagers , Jack007 , Ryan Miller , Marvin Martens , Jonas Hummel , Stan Gaj , Vanessa Sousa , Allan Kuchinsky , Asios Olia , Aishwarya Iyer , Luigi Maiorana , Eric Jaehnig , Michiel Adriaens , Chris Evelo , Patrick Ahles , Adrien Defay , Priyanka K , Licong , Anwesha Bohler , Aaron Caine , Etaglobin , Mark Scott , Kdahlquist , Nick Fidelman , The Herald , Mirk Baranzini , Mark A. Hershberger , Ambar21 , Jonathan Mélius , Roelod , Akhilesh Pandey , Axel Weber , NetPath , Joppe014 , Shamith Samarajiwa , Bingo , Elisa Cirillo , Maria van de Meent , Pieter Giesbertz , Konstantina Pandi , Chetan1 , Frank , Txr24 , Egoyenechea , Jeff , Garima Thakur , Liling , Ruud Weijer , Franziska Kreidl , Linda Rieswijk , Melodyner , Jack Youngren , Nurit Gal , Samuel Sklar , Glenda Nicioli Da Silva , Jlw9 , Hubert Hug , Agustin Gonzalez-Vicente , Dr.P.R.Sudhakaran , Marlen m , Sharona Elgavish , Lora Simons , Michael Lieberman , Ericwexler , Mick Eikelhof , and Max Van Son .