EBV LMP1 signaling (WP984)

Bos taurus

PDLIM7 (latent membrane protein 1 / LMP1 in Homo sapiens) of the Ebstein-Barr Virus (EBV) elicits its oncogenic effects through the activation of several downstream pathways such as Pi3K/akt, IRF4, and NFkB pathways.

Authors

Alex Pico , Martina Summer-Kutmon , and Eric Weitz

Activity

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Cited In

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

Epstein-Barr virus infection pathway

Participants

Label Type Compact URI Comment
MAP3K3 GeneProduct ensembl:ENSBTAG00000008151 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198909
NFKB2 GeneProduct ensembl:ENSBTAG00000006017 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000077150
MAPK8 GeneProduct ensembl:ENSBTAG00000007876 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000107643
RELA GeneProduct ensembl:ENSBTAG00000013895 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000173039
PDLIM7 GeneProduct ensembl:ENSBTAG00000007343 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196923
BIKBA GeneProduct ensembl:ENSBTAG00000016683 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100906
CXCL8 GeneProduct ensembl:ENSBTAG00000019716 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169429
TRADD GeneProduct ensembl:ENSBTAG00000012642 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000102871
IL6 GeneProduct ensembl:ENSBTAG00000046456 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171855
IKBKB GeneProduct ensembl:ENSBTAG00000007599 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000104365
TRAF6 GeneProduct ensembl:ENSBTAG00000036009 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000175104
CHUK GeneProduct ensembl:ENSBTAG00000007591 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000213341
MAP3K7 GeneProduct ensembl:ENSBTAG00000002625 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135341
NFKB1 GeneProduct ensembl:ENSBTAG00000020270 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000109320
IRAK1 GeneProduct ensembl:ENSBTAG00000016085 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000184216
TRAF1 GeneProduct ensembl:ENSBTAG00000003012 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000056558
MAP3K14 GeneProduct ensembl:ENSBTAG00000007084 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000006062
CHUK GeneProduct ensembl:ENSBTAG00000007591 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1147
CCL20 GeneProduct ensembl:ENSBTAG00000021326 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115009
MAPK1 GeneProduct ensembl:ENSBTAG00000010312 HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100030
HSP90AA1 GeneProduct ensembl:ENSBTAG00000006270 HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3320

References

  1. TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB. Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, et al. J Biol Chem. 2006 Mar 24;281(12):7863–72. PubMed Europe PMC Scholia
  2. IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation. Song YJ, Jen KY, Soni V, Kieff E, Cahir-McFarland E. Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2689–94. PubMed Europe PMC Scholia
  3. Expression and regulation of the CC-chemokine ligand 20 during human tuberculosis. Lee JS, Lee JY, Son JW, Oh JH, Shin DM, Yuk JM, et al. Scand J Immunol. 2008 Jan;67(1):77–85. PubMed Europe PMC Scholia
  4. Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB. Battaglia F, Delfino S, Merello E, Puppo M, Piva R, Varesio L, et al. J Leukoc Biol. 2008 Mar;83(3):648–62. PubMed Europe PMC Scholia