EBV LMP1 signaling (WP984)
Bos taurus
PDLIM7 (latent membrane protein 1 / LMP1 in Homo sapiens) of the Ebstein-Barr Virus (EBV) elicits its oncogenic effects through the activation of several downstream pathways such as Pi3K/akt, IRF4, and NFkB pathways.
Authors
Alex Pico , Martina Summer-Kutmon , and Eric WeitzActivity
Discuss this pathway
Check for ongoing discussions or start your own.
Cited In
Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.
Organisms
Bos taurusCommunities
Annotations
Pathway Ontology
Epstein-Barr virus infection pathwayLabel | Type | Compact URI | Comment |
---|---|---|---|
MAP3K3 | GeneProduct | ensembl:ENSBTAG00000008151 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198909 |
NFKB2 | GeneProduct | ensembl:ENSBTAG00000006017 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000077150 |
MAPK8 | GeneProduct | ensembl:ENSBTAG00000007876 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000107643 |
RELA | GeneProduct | ensembl:ENSBTAG00000013895 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000173039 |
PDLIM7 | GeneProduct | ensembl:ENSBTAG00000007343 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196923 |
BIKBA | GeneProduct | ensembl:ENSBTAG00000016683 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100906 |
CXCL8 | GeneProduct | ensembl:ENSBTAG00000019716 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169429 |
TRADD | GeneProduct | ensembl:ENSBTAG00000012642 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000102871 |
IL6 | GeneProduct | ensembl:ENSBTAG00000046456 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171855 |
IKBKB | GeneProduct | ensembl:ENSBTAG00000007599 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000104365 |
TRAF6 | GeneProduct | ensembl:ENSBTAG00000036009 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000175104 |
CHUK | GeneProduct | ensembl:ENSBTAG00000007591 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000213341 |
MAP3K7 | GeneProduct | ensembl:ENSBTAG00000002625 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135341 |
NFKB1 | GeneProduct | ensembl:ENSBTAG00000020270 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000109320 |
IRAK1 | GeneProduct | ensembl:ENSBTAG00000016085 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000184216 |
TRAF1 | GeneProduct | ensembl:ENSBTAG00000003012 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000056558 |
MAP3K14 | GeneProduct | ensembl:ENSBTAG00000007084 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000006062 |
CHUK | GeneProduct | ensembl:ENSBTAG00000007591 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1147 |
CCL20 | GeneProduct | ensembl:ENSBTAG00000021326 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115009 |
MAPK1 | GeneProduct | ensembl:ENSBTAG00000010312 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100030 |
HSP90AA1 | GeneProduct | ensembl:ENSBTAG00000006270 | HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3320 |
References
- TAK1 is a component of the Epstein-Barr virus LMP1 complex and is essential for activation of JNK but not of NF-kappaB. Uemura N, Kajino T, Sanjo H, Sato S, Akira S, Matsumoto K, et al. J Biol Chem. 2006 Mar 24;281(12):7863–72. PubMed Europe PMC Scholia
- IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation. Song YJ, Jen KY, Soni V, Kieff E, Cahir-McFarland E. Proc Natl Acad Sci U S A. 2006 Feb 21;103(8):2689–94. PubMed Europe PMC Scholia
- Expression and regulation of the CC-chemokine ligand 20 during human tuberculosis. Lee JS, Lee JY, Son JW, Oh JH, Shin DM, Yuk JM, et al. Scand J Immunol. 2008 Jan;67(1):77–85. PubMed Europe PMC Scholia
- Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB. Battaglia F, Delfino S, Merello E, Puppo M, Piva R, Varesio L, et al. J Leukoc Biol. 2008 Mar;83(3):648–62. PubMed Europe PMC Scholia