Apoptosis (WP1254)

Mus musculus

Open in new tab Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads

Apoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and membrane blebbing characterize apoptosis in general. Mitochondria remain morphologically unchanged. In 1972 Kerr et al introduced the concept of apoptosis as a distinct form of “cell-death”, and the mechanisms of various apoptotic pathways are still being revealed today.

Authors

Martijn Van Iersel , Thomas Kelder , Christine Chichester , Alex Pico , and Martina Summer-Kutmon

Activity

last edited pathway curation

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

regulatory pathway

Participants

Label Type Compact URI Comment
Pmaip1 GeneProduct ensembl:ENSMUSG00000024521 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5366
Casp9 GeneProduct ensembl:ENSMUSG00000028914 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:842
Mdm2 GeneProduct ensembl:ENSMUSG00000020184 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4193
Bak1 GeneProduct ensembl:ENSMUSG00000057789 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:578
Traf3 GeneProduct ensembl:ENSMUSG00000021277 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7187
Irf1 GeneProduct ensembl:ENSMUSG00000018899 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3659
Nfkb1 GeneProduct ensembl:ENSMUSG00000028163 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4790
Fas GeneProduct ensembl:ENSMUSG00000024778 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:355
Birc2 GeneProduct ensembl:ENSMUSG00000057367 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:329
Diablo GeneProduct ensembl:ENSMUSG00000029433 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:56616
Akt1 GeneProduct ensembl:ENSMUSG00000001729 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:207
Gzmc GeneProduct ensembl:ENSMUSG00000079186 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3002
Tnfrsf21 GeneProduct ensembl:ENSMUSG00000023915 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:27242
Bad GeneProduct ensembl:ENSMUSG00000024959 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:572
Nfkbia GeneProduct ensembl:ENSMUSG00000021025 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4792
Casp1 GeneProduct ensembl:ENSMUSG00000025888 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:834
Ripk1 GeneProduct ensembl:ENSMUSG00000021408 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8737
Irf2 GeneProduct ensembl:ENSMUSG00000031627 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3660
Nfkbib GeneProduct ensembl:ENSMUSG00000030595 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4793
Lta GeneProduct ensembl:ENSMUSG00000024402 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4049
Casp4 GeneProduct ensembl:ENSMUSG00000033538 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:837
Irf6 GeneProduct ensembl:ENSMUSG00000026638 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3664
Casp3 GeneProduct ensembl:ENSMUSG00000031628 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:836
Prf1 GeneProduct ensembl:ENSMUSG00000037202 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5551
Tnfrsf1a GeneProduct ensembl:ENSMUSG00000030341 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7132
Igf1r GeneProduct ensembl:ENSMUSG00000005533 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3480
Rela GeneProduct ensembl:ENSMUSG00000024927 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5970
Chuk GeneProduct ensembl:ENSMUSG00000025199 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1147
Bax GeneProduct ensembl:ENSMUSG00000003873 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:581
Apaf1 GeneProduct ensembl:ENSMUSG00000019979 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:317
Tnfrsf1b GeneProduct ensembl:ENSMUSG00000028599 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7133
Birc3 GeneProduct ensembl:ENSMUSG00000032000 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:330
Bid GeneProduct ensembl:ENSMUSG00000004446 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:637
Tnfrsf25 GeneProduct ensembl:ENSMUSG00000024793 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8718
Mapk10 GeneProduct ensembl:ENSMUSG00000046709 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5602
Traf1 GeneProduct ensembl:ENSMUSG00000026875 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7185
Ikbkb GeneProduct ensembl:ENSMUSG00000031537 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3551
Irf5 GeneProduct ensembl:ENSMUSG00000029771 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3663
Dffa GeneProduct ensembl:ENSMUSG00000028974 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1676
Irf3 GeneProduct ensembl:ENSMUSG00000003184 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3661
Casp2 GeneProduct ensembl:ENSMUSG00000029863 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:835
Hrk GeneProduct ensembl:ENSMUSG00000046607 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8739
Trp73 GeneProduct ensembl:ENSMUSG00000029026 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7161
Scaf11 GeneProduct ensembl:ENSMUSG00000033228 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:9169
Casp7 GeneProduct ensembl:ENSMUSG00000025076 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:840
Myc GeneProduct ensembl:ENSMUSG00000022346 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4609
Tnf GeneProduct ensembl:ENSMUSG00000024401 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7124
Igf2 GeneProduct ensembl:ENSMUSG00000048583 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3481
Cradd GeneProduct ensembl:ENSMUSG00000045867 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8738
Ikbkg GeneProduct ensembl:ENSMUSG00000004221 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8517
Bok GeneProduct ensembl:ENSMUSG00000026278 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:666
Traf2 GeneProduct ensembl:ENSMUSG00000026942 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7186
Cflar GeneProduct ensembl:ENSMUSG00000026031 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8837
Bcl2l2 GeneProduct ensembl:ENSMUSG00000089682 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:599
Pik3r1 GeneProduct ensembl:ENSMUSG00000041417 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5295
Tradd GeneProduct ensembl:ENSMUSG00000031887 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8717
Birc5 GeneProduct ensembl:ENSMUSG00000017716 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:332
Igf1 GeneProduct ensembl:ENSMUSG00000020053 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3479
Tnfrsf10b GeneProduct ensembl:ENSMUSG00000022074 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8795
Jun GeneProduct ensembl:ENSMUSG00000052684 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3725
Bnip3l GeneProduct ensembl:ENSMUSG00000022051 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:665
Dffb GeneProduct ensembl:ENSMUSG00000029027 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1677
Bcl2 GeneProduct ensembl:ENSMUSG00000057329 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:596
Irf7 GeneProduct ensembl:ENSMUSG00000025498 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3665
Bcl2l1 GeneProduct ensembl:ENSMUSG00000007659 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:598
Irf4 GeneProduct ensembl:ENSMUSG00000021356 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3662
Nfkbie GeneProduct ensembl:ENSMUSG00000023947 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4794
Trp53 GeneProduct ensembl:ENSMUSG00000059552 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7157
Map2k4 GeneProduct ensembl:ENSMUSG00000033352 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6416
Casp8 GeneProduct ensembl:ENSMUSG00000026029 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:841
Xiap GeneProduct ensembl:ENSMUSG00000025860 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:331
Fasl GeneProduct ensembl:ENSMUSG00000000817 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:356
Tnfsf10 GeneProduct ensembl:ENSMUSG00000039304 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8743
Hells GeneProduct ensembl:ENSMUSG00000025001 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3070
Fadd GeneProduct ensembl:ENSMUSG00000031077 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8772
Mcl1 GeneProduct ensembl:ENSMUSG00000038612 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4170
Casp6 GeneProduct ensembl:ENSMUSG00000027997 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:839
Bcl2l11 GeneProduct ensembl:ENSMUSG00000027381 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10018
Map3k1 GeneProduct ensembl:ENSMUSG00000021754 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4214
Trp63 GeneProduct ensembl:ENSMUSG00000022510 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8626

References

  1. Regulation of p53 in response to DNA damage. Lakin ND, Jackson SP. Oncogene. 1999 Dec 13;18(53):7644–55. PubMed Europe PMC Scholia
  2. mir-29 regulates Mcl-1 protein expression and apoptosis. Mott JL, Kobayashi S, Bronk SF, Gores GJ. Oncogene. 2007 Sep 13;26(42):6133–40. PubMed Europe PMC Scholia
  3. The p53-MDM2 network: from oscillations to apoptosis. Bose I, Ghosh B. J Biosci. 2007 Aug;32(5):991–7. PubMed Europe PMC Scholia
  4. miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42. Park SY, Lee JH, Ha M, Nam JW, Kim VN. Nat Struct Mol Biol. 2009 Jan;16(1):23–9. PubMed Europe PMC Scholia