Kit receptor signaling pathway (WP886)

Pan troglodytes

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Kit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets among others. Binding of Kit receptor to stem cell factor leads to an intracellular cascade of events that includes activation of PI 3-kinase, Src family kinases and PLC gamma. Activating mutations in the Kit receptor are associated with several human malignancies include leukemias, gastrointestinal stromal tumors and mastocytomas. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_6

Authors

Alex Pico , Daniela Digles , and Eric Weitz

Activity

last edited

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Organisms

Pan troglodytes

Communities

Annotations

Pathway Ontology

Stem Cell Factor signaling pathway

Participants

Label Type Compact URI Comment
GRB7 GeneProduct ncbigene:454637
PIK3R1 GeneProduct ncbigene:461836
PIK3R2 GeneProduct ncbigene:455855
SHC1 GeneProduct ncbigene:457351
CSF2RB GeneProduct ncbigene:458802
GRB2 GeneProduct ncbigene:737245
SOCS6 GeneProduct ncbigene:455521
SOCS4 GeneProduct ncbigene:452919
SOCS5 GeneProduct ncbigene:459209
CISH GeneProduct ncbigene:470819
CLTC GeneProduct ncbigene:455168
CRK GeneProduct ncbigene:747142
SRC GeneProduct ncbigene:458229
PLCE1 GeneProduct ncbigene:450620
JAK2 GeneProduct ncbigene:464979
GRAP GeneProduct ncbigene:454496
PTPRU GeneProduct ncbigene:456692
STAP1 GeneProduct ncbigene:471228
PRKCA GeneProduct ncbigene:454832
PLCG1 GeneProduct ncbigene:458253
STAT1 GeneProduct ncbigene:459834
STAT5A GeneProduct ncbigene:454681
STAT5B GeneProduct ncbigene:454679
PIK3CG GeneProduct ncbigene:463649
SH2B2 GeneProduct ncbigene:741557
GRB10 GeneProduct ncbigene:463410
AKT1 GeneProduct ncbigene:740898
TEC GeneProduct ncbigene:461343
LYN GeneProduct ncbigene:472771
DOK1 GeneProduct ncbigene:741064
PTPN6 GeneProduct ncbigene:748032
PTPN11 GeneProduct ncbigene:748225
EPOR GeneProduct ncbigene:455728
MITF GeneProduct ncbigene:460500
MAPK1 GeneProduct ncbigene:458680
ABL1 GeneProduct ncbigene:464802
INPP5D GeneProduct ncbigene:470683
FGR GeneProduct ncbigene:739516
HCK GeneProduct ncbigene:458163
YES1 GeneProduct ncbigene:455322
RASA1 GeneProduct ncbigene:461762
FES GeneProduct ncbigene:453654
CRKL GeneProduct ncbigene:470146
CBL GeneProduct ncbigene:451690
SOCS1 GeneProduct ncbigene:737070
VAV1 GeneProduct ncbigene:455647
SOS1 GeneProduct ncbigene:459171
EP300 GeneProduct ncbigene:458862
FYN GeneProduct ncbigene:462944
HRAS GeneProduct ncbigene:466302
RAF1 GeneProduct ncbigene:460182
SPRED2 GeneProduct ncbigene:459284
SPRED1 GeneProduct ncbigene:467654
SH3KBP1 GeneProduct ncbigene:465527
CBLB GeneProduct ncbigene:460566
TNFRSF10A GeneProduct ncbigene:743159
BTK GeneProduct ncbigene:465759
KIT GeneProduct ncbigene:461316
KITLG GeneProduct ncbigene:452114
MAP2K1 GeneProduct ncbigene:450188
STAT3 GeneProduct ncbigene:454682
MPDZ GeneProduct ncbigene:473169

References