Estrogen signaling (WP1330)

Danio rerio

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Estrogen receptor refers to a group of receptors which are activated by the hormone 17β-estradiol (estrogen). Two types of estrogen receptor exist: ER which is a member of the nuclear hormone family of intracellular receptors and the estrogen G protein coupled receptor GPR30 (GPER), which is a G-protein coupled receptor. The main function of the estrogen receptor is as a DNA binding transcription factor which regulates gene expression. However the estrogen receptor also has additional functions independent of DNA binding.

For a description of pathway objects, see the WikiPathways Legend.

Authors

Alex Pico , Susan Coort , and Eric Weitz

Activity

last edited

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Organisms

Danio rerio

Communities

Annotations

Pathway Ontology

estrogen signaling pathway

Participants

Label Type Compact URI Comment
Estradiol Metabolite hmdb:HMDB0000151
Cyclic AMP Metabolite hmdb:HMDB0000058
LOC100149273 GeneProduct ncbigene:100149273
ercc2 GeneProduct ncbigene:393900
taf7 GeneProduct ncbigene:100002261
taf13 GeneProduct ncbigene:324153
mapk1 GeneProduct ensembl:ENSDARG00000027552
mnat1 GeneProduct ncbigene:450080
ccnd1 GeneProduct ncbigene:30222
gtf2b GeneProduct ncbigene:324823
BCL2 GeneProduct ncbigene:570772
hdac3 GeneProduct ncbigene:393965 HDAC3; histone deacetylase 3
ercc3 GeneProduct ncbigene:324323
esr1 GeneProduct ncbigene:259252
creb1 GeneProduct ncbigene:573207
LOC561737 GeneProduct ncbigene:561737
ep300a GeneProduct ncbigene:559273
ikbkb GeneProduct ensembl:ENSDARG00000079123
ncor1 GeneProduct ncbigene:393246
LOC792188 GeneProduct ncbigene:792188
LOC100149268 GeneProduct ncbigene:100149268
zgc:158799 GeneProduct ncbigene:564064
LOC792258 GeneProduct ncbigene:792258
TAF12 GeneProduct ncbigene:386637
cdk7 GeneProduct ncbigene:405897
jun GeneProduct ncbigene:335916
LOC557353 GeneProduct ncbigene:557353
LOC792354 GeneProduct ncbigene:792354
si:ch211-194d6.2 GeneProduct ncbigene:567899
hdac6 GeneProduct ncbigene:565482 HDAC6; histone deacetylase 6
taf9 GeneProduct ncbigene:321485
polr2e GeneProduct ncbigene:445170
gtf2h4 GeneProduct ncbigene:334839
zgc:92126 GeneProduct ncbigene:447857
GNB1 GeneProduct ncbigene:322104
zgc:110584 GeneProduct ncbigene:798997
gtf2e2 GeneProduct ncbigene:334854
src GeneProduct ncbigene:325084
GTF2F2 GeneProduct ncbigene:415217
ikbkg GeneProduct ensembl:ENSDARG00000017037
polr2j GeneProduct ncbigene:554099
braf GeneProduct ncbigene:403065
map2k1 GeneProduct ensembl:ENSDARG00000007825
mapk14a GeneProduct ncbigene:65237
LOC567895 GeneProduct ncbigene:567895
si:dkey-94n12.3 GeneProduct ncbigene:562011
hdac1 GeneProduct ncbigene:192302 HDAC1; histone deacetylase 1
taf6 GeneProduct ncbigene:447818
tbp GeneProduct ncbigene:368882
crebbpb GeneProduct ncbigene:503776
gper GeneProduct ncbigene:565271
fos GeneProduct ncbigene:394198
LOC791979 GeneProduct ncbigene:791979
grb2 GeneProduct ncbigene:406308
ilk GeneProduct ncbigene:393543
gtf2h2 GeneProduct ncbigene:323239
taf5 GeneProduct ncbigene:641491
gngt1 GeneProduct ncbigene:335656
polr2gl GeneProduct ncbigene:324088
LOC557486 GeneProduct ncbigene:557486 HDAC5; histone deacetylase 5
hdac8 GeneProduct ncbigene:406740 HDAC8; histone deacetylase
hdac4 GeneProduct ncbigene:568877 HDAC4; histone deacetylase 4
GTF2H3 GeneProduct ncbigene:436837
polr2a GeneProduct ncbigene:553347
ccnh GeneProduct ncbigene:541325
sp1 GeneProduct ncbigene:324109
chuk GeneProduct ensembl:ENSDARG00000011662

References