Integrin-mediated cell adhesion (WP6)

Mus musculus

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Integrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the extracellular matrix (ECM). They also play a role in cell signaling and thereby define cellular shape, mobility, and regulate the cell cycle. Source: [[wikipedia:Integrins|Wikipedia]]

Authors

Thomas Kelder , Daniela Digles , Alex Pico , Martina Summer-Kutmon , Denise Slenter , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

integrin mediated signaling pathway

Participants

Label Type Compact URI Comment
Itga4 GeneProduct ncbigene:16401
Capn9 GeneProduct ncbigene:73647 CAPN9; calpain 9 (nCL-4) [EC:3.4.22.17
Actn1 GeneProduct ncbigene:109711
Ilk GeneProduct ncbigene:16202 ILK; integrin-linked kinase [EC:2.7.1.-]
Ptk2 GeneProduct ncbigene:14083 PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112
Itgb3 GeneProduct ncbigene:16416
Itgae GeneProduct ncbigene:16407
Sos1 GeneProduct ncbigene:20662 SOS1; son of sevenless homolog 1 (Drosophila)
Zyx GeneProduct ncbigene:22793 ZYX; zyxin
Rap1a GeneProduct ncbigene:109905 RAP1A; RAP1A member of RAS oncogene family
Itgam GeneProduct ncbigene:16409
Crk GeneProduct ncbigene:12928 CRK; v-crk sarcoma virus CT10 oncogene homolog (avian
Itga7 GeneProduct ncbigene:16404
Itgb7 GeneProduct ncbigene:16421
Capn5 GeneProduct ncbigene:12337 CAPN5; calpain
Itgad GeneProduct ncbigene:381924
Sepp1 GeneProduct ncbigene:20363 SEPP1; selenoprotein P plasma
Rock1 GeneProduct ncbigene:19877 ROCK1; Rho-associated coiled-coil containing protein kinase
Itgav GeneProduct ncbigene:16410
Itga3 GeneProduct ncbigene:16400
Vcl GeneProduct ncbigene:22330 VCL; vinculin
Rapgef1 GeneProduct ncbigene:107746 GRF2; guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene
Itga2b GeneProduct ncbigene:16399
Capn6 GeneProduct ncbigene:12338 CAPN6; calpain 6 [EC:3.4.22.17]
Rac2 GeneProduct ncbigene:19354 RAC2; ras-related C3 botulinum toxin substrate 2 (rho family small GTP binding protein Rac2)
Pxn GeneProduct ncbigene:19303 PXN; paxillin
Pak6 GeneProduct ncbigene:214230 PAK6; p21(CDKN1A)-activated kinase
Map2k1 GeneProduct ncbigene:26395 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]
Bcar1 GeneProduct ncbigene:12927 BCAR1; breast cancer anti-estrogen resistance 1
Itgb4 GeneProduct ncbigene:192897
Itgb8 GeneProduct ncbigene:320910
Pdpk1 GeneProduct ncbigene:18607 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.1.37]
Capn3 GeneProduct ncbigene:12335 CAPN3; calpain 3 (p94) [EC:3.4.22.17]
Src GeneProduct ncbigene:20779 SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]
Dock1 GeneProduct ncbigene:330662 DOCK1; dedicator of cyto-kinesis
Vav3 GeneProduct ncbigene:57257 VAV3; vav 3 oncogene
Braf GeneProduct ncbigene:109880 BRAF; v-raf murine sarcoma viral oncogene homolog B1 [EC:2.7.1.-]
Cav2 GeneProduct ncbigene:12390 CAV2; caveolin 2
Itgal GeneProduct ncbigene:16408
Araf GeneProduct ncbigene:11836 ARAF1; v-raf murine sarcoma 3611 viral oncogene homolog 1 [EC:2.7.1.-]
Capn11 GeneProduct ncbigene:268958 CAPN11; calpain 11 [EC:3.4.22.17]
Capn10 GeneProduct ncbigene:23830 CAPN10; calpain 10 [EC:3.4.22.17
Itgax GeneProduct ncbigene:16411
Itga1 GeneProduct ncbigene:109700
Fyn GeneProduct ncbigene:14360 FYN; FYN oncogene related to SRC FGR YES [EC:2.7.1.112]
Mapk10 GeneProduct ncbigene:26414
Csk GeneProduct ncbigene:12988 CSK; c-src tyrosine kinase [EC:2.7.1.112]
Cav3 GeneProduct ncbigene:12391 CAV3; caveolin 3
Rho GeneProduct ncbigene:212541 RHO; rhodopsin (opsin 2 rod pigment) (retinitis pigmentosa 4 autosomal dominant)
Hras1 GeneProduct ncbigene:15461
Mapk7 GeneProduct ncbigene:23939 MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.-
Cav1 GeneProduct ncbigene:12389 CAV1; caveolin 1 caveolae protein 22kD
Itgb6 GeneProduct ncbigene:16420
Mapk6 GeneProduct ncbigene:50772 MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]
Shc1 GeneProduct ncbigene:20416 SHC1; SHC (Src homology 2 domain containing) transforming protein 1
Itgb1 GeneProduct ncbigene:16412
Capn2 GeneProduct ncbigene:12334 CAPN2; calpain 2 (m/II) large subunit [EC:3.4.22.17]
Akt3 GeneProduct ncbigene:23797 AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) [EC:2.7.1.-]
Map2k2 GeneProduct ncbigene:26396 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]
Pik3r2 GeneProduct ncbigene:18709 PIK3R2; phosphoinositide-3-kinase regulatory subunit polypeptide 2 (p85 beta)
Itga9 GeneProduct ncbigene:104099
Tns1 GeneProduct ncbigene:21961 TNS; tensi
Capn7 GeneProduct ncbigene:12339 CAPN7; calpain 7 [EC:3.4.22.17
Itga5 GeneProduct ncbigene:16402
Itga10 GeneProduct ncbigene:213119
Raf1 GeneProduct ncbigene:110157 RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]
Vav2 GeneProduct ncbigene:22325 VAV2; vav 2 oncogene
Cdc42 GeneProduct ncbigene:12540 CDC42; cell division cycle 42 (GTP binding protein 25kD)
Map2k5 GeneProduct ncbigene:23938 MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-]
Capns1 GeneProduct ncbigene:12336 CAPNS1; calpain small subunit 1 [EC:3.4.22.17]
Itgb2 GeneProduct ncbigene:16414
Pak2 GeneProduct ncbigene:224105 PAK2; p21 (CDKN1A)-activated kinase 2 [EC:2.7.1.-]
Map2k3 GeneProduct ncbigene:26397 MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-]
Mapk1 GeneProduct ncbigene:26413 MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]
Sorbs1 GeneProduct ncbigene:20411 SH3D5; SH3-domain protein 5 (ponsin
Rap1b GeneProduct ncbigene:215449 RAP1B; RAP1B member of RAS oncogene family
Map2k6 GeneProduct ncbigene:26399 MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.-
Pak3 GeneProduct ncbigene:18481 PAK3; p21 (CDKN1A)-activated kinase 3 [EC:2.7.1.-]
Itga2 GeneProduct ncbigene:16398
Akt2 GeneProduct ncbigene:11652 AKT2; v-akt murine thymoma viral oncogene homolog 2 [EC:2.7.1.-]
Capn1 GeneProduct ncbigene:12333 CAPN1; calpain 1 (mu/I) large subunit [EC:3.4.22.17]
Rac1 GeneProduct ncbigene:19353 RAC1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1)
Rock2 GeneProduct ncbigene:19878 ROCK2; Rho-associated coiled-coil containing protein kinase
Git2 GeneProduct ncbigene:26431 GIT2; G protein-coupled receptor kinase-interactor 2
Myo GeneProduct uniprot:17928
Vasp GeneProduct ncbigene:22323 VASP; vasodilator-stimulated phosphoprotein
Itga6 GeneProduct ncbigene:16403
Pak1 GeneProduct ncbigene:18479 PAK1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog yeast) [EC:2.7.1.-]
Akt1 GeneProduct ncbigene:11651 AKT1; v-akt murine thymoma viral oncogene homolog 1 [EC:2.7.1.-]
Grb2 GeneProduct ncbigene:14784 GRB2; growth factor receptor-bound protein 2
Itgb5 GeneProduct ncbigene:16419
Itga8 GeneProduct ncbigene:241226
Itga11 GeneProduct ncbigene:319480
Arhgef7 GeneProduct ncbigene:54126 ARHGEF7; Rho guanine nucleotide exchange factor (GEF) 7
Mylk2 GeneProduct ncbigene:228785 MYLK2; myosin light chain kinase 2 skeletal muscle [EC:2.7.1.117
Pak4 GeneProduct ncbigene:70584 PAK4; p21(CDKN1A)-activated kinase 4 [EC:2.7.1.-]
Mapk4 GeneProduct ncbigene:225724 MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-]
Mapk12 GeneProduct ncbigene:29857 MAPK12; mitogen-activated protein kinase 12 [EC:2.7.1.-]
Rac3 GeneProduct ncbigene:170758 RAC3; ras-related C3 botulinum toxin substrate 3 (rho family small GTP binding protein Rac3)
Tln1 GeneProduct ncbigene:21894 TLN1; talin 1
Shc3 GeneProduct ncbigene:20418 SHC3; neuronal Sh

References

  1. Assembly and signaling of adhesion complexes. Sepulveda JL, Gkretsi V, Wu C. Curr Top Dev Biol. 2005;68:183–225. PubMed Europe PMC Scholia