Hedgehog signaling pathway (WP905)

Pan troglodytes

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The Hedgehog proteins are a family of secreted ligands that include sonic hedgehog, Indian hedgehog and desert hedgehog in humans. Binding of Hedgehog ligands to their receptors, Patched 1 and 2, prevents inhibition of a 7 transmembrane receptor called Smoothened. This leads to activation of GLI family of transcription factors (GLI1-3). Signaling through the Hedgehog pathway is essential for development of many tissues and organs. This pathway is highly conserved among metazoans. Aberrant activation of this pathway has been associated with a number of human malignancies including carcinoma of lung, esophagus, pancreas and prostate. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_10

Authors

Alex Pico , Christine Chichester , and Eric Weitz

Activity

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Organisms

Pan troglodytes

Communities

Annotations

Pathway Ontology

Hedgehog signaling pathway

Participants

Label Type Compact URI Comment
PTCH2 GeneProduct ncbigene:469185
SHH GeneProduct ncbigene:743371
CDC2 GeneProduct ncbigene:450481
SMO GeneProduct ncbigene:463718
IHH GeneProduct ncbigene:470652
GLI3 GeneProduct ncbigene:463369
SUFU GeneProduct ncbigene:450699
SAP18 GeneProduct ncbigene:452467
SIN3A GeneProduct ncbigene:453759
GLI1 GeneProduct ncbigene:452014
GAS1 GeneProduct ncbigene:736324
CREBBP GeneProduct ncbigene:467891
DYRK1A GeneProduct ncbigene:458545
GLI2 GeneProduct ncbigene:459582
STK36 GeneProduct ncbigene:459948
CCNB1 GeneProduct ncbigene:461835
RAB23 GeneProduct ncbigene:472043
IGF2 GeneProduct ncbigene:742381
HHIP GeneProduct ncbigene:461521

References

  1. Requirements for hedgehog, a segmental polarity gene, in patterning larval and adult cuticle of Drosophila. Mohler J. Genetics. 1988 Dec;120(4):1061–72. PubMed Europe PMC Scholia
  2. The Hedgehog response network: sensors, switches, and routers. Lum L, Beachy PA. Science. 2004 Jun 18;304(5678):1755–9. PubMed Europe PMC Scholia