PPAR signaling pathway (WP2316)

Mus musculus

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Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake. Adapted from KEGG: http://www.genome.jp/kegg/pathway/mmu/mmu03320.html

Authors

Thomas Kelder , Daniela Digles , Alex Pico , Kristina Hanspers , Denise Slenter , Friederike Ehrhart , and Felicia Castriota

Activity

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Organisms

Mus musculus

Communities

Annotations

Cell Type Ontology

white fat cell cell of skeletal muscle

Pathway Ontology

peroxisome proliferator-activated receptor signaling pathway transcription factor mediated signaling pathway signaling pathway

Participants

Label Type Compact URI Comment
unsaturated fatty acids Metabolite chebi:27208
saturated fatty acids Metabolite chebi:26607
eicosanoid Metabolite chebi:23899
Ciprofibrate Metabolite wikidata:Q3496452
NSAIDs Metabolite chebi:35475
9-cis-Retinoic acid Metabolite hmdb:HMDB0002369
Thiazolidine derivative Metabolite chebi:35622
Acaa1b GeneProduct ncbigene:235674 Original kegg element: gene;21;mmu:113868 mmu:235674
Ppard GeneProduct ncbigene:19015 Original kegg element: gene;16;mmu:19015
Pparg GeneProduct ncbigene:19016 Original kegg element: gene;18;mmu:19016
Ubc GeneProduct ncbigene:22190 Original kegg element: gene;62;mmu:22190
Pck2 GeneProduct ncbigene:74551 Original kegg element: gene;9;mmu:18534 mmu:74551
Cyp4a31 GeneProduct ncbigene:666168 Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
Cyp8b1 GeneProduct ncbigene:13124 Original kegg element: gene;58;mmu:13124
Ucp1 GeneProduct ncbigene:22227 Original kegg element: gene;66;mmu:22227
Slc27a1 GeneProduct ncbigene:26457 Original kegg element: gene;36;mmu:26457 mmu:26569
Hmgcs2 GeneProduct ncbigene:15360 Original kegg element: gene;37;mmu:15360
Cyp4a10 GeneProduct ncbigene:13117 Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
Rxrb GeneProduct ncbigene:20182 Original kegg element: gene;17;mmu:20181 mmu:20182 mmu:20183
Aqp7 GeneProduct ncbigene:11832 Original kegg element: gene;7;mmu:11832
Scd2 GeneProduct ncbigene:20250 Original kegg element: gene;55;mmu:20249 mmu:20250 mmu:30049 mmu:329065
Acox1 GeneProduct ncbigene:11430 Original kegg element: gene;42;mmu:11430 mmu:80911 mmu:93732
Cyp4a12b GeneProduct ncbigene:13118 Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
Adipocytokine signaling pathway GeneProduct kegg.genes:path:mmu04920 Original kegg element: map;34;path:mmu04920
Scd3 GeneProduct ncbigene:30049 Original kegg element: gene;55;mmu:20249 mmu:20250 mmu:30049 mmu:329065
Scd4 GeneProduct ncbigene:329065 Original kegg element: gene;55;mmu:20249 mmu:20250 mmu:30049 mmu:329065
Nr1h3 GeneProduct ncbigene:22259 Original kegg element: gene;59;mmu:22259
Rxra GeneProduct ncbigene:20181 Original kegg element: gene;19;mmu:20181 mmu:20182 mmu:20183
Acsbg2 GeneProduct ncbigene:328845 Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
Fabp1 GeneProduct ncbigene:14080 Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
Cyp4a14 GeneProduct ncbigene:13119 Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
Rxrg GeneProduct ncbigene:20183 Original kegg element: gene;19;mmu:20181 mmu:20182 mmu:20183
Rxrb GeneProduct ncbigene:20182 Original kegg element: gene;19;mmu:20181 mmu:20182 mmu:20183
Acsl6 GeneProduct ncbigene:216739 Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
Angptl4 GeneProduct ncbigene:57875 Original kegg element: gene;41;mmu:57875
Cyp27a1 GeneProduct ncbigene:104086 Original kegg element: gene;60;mmu:104086
Acsl3 GeneProduct ncbigene:74205 Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
Fabp7 GeneProduct ncbigene:12140 Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
Acadm GeneProduct ncbigene:11364 Original kegg element: gene;22;mmu:11364
Cpt1b GeneProduct ncbigene:12895 Original kegg element: gene;27;mmu:12894 mmu:12895 mmu:78070
Cpt1c GeneProduct ncbigene:78070 Original kegg element: gene;27;mmu:12894 mmu:12895 mmu:78070
Rxra GeneProduct ncbigene:20181 Original kegg element: gene;15;mmu:20181 mmu:20182 mmu:20183
Cyp4a12a GeneProduct ncbigene:277753 Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
Fabp3 GeneProduct ncbigene:14077 Original kegg element: gene;32;mmu:14077
Cyp4a32 GeneProduct ncbigene:100040843 Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
Fabp2 GeneProduct ncbigene:14079 Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
Acsl4 GeneProduct ncbigene:50790 Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
Dbi GeneProduct ncbigene:13167 Original kegg element: gene;63;mmu:13167
Slc27a2 GeneProduct ncbigene:26458 Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569
Slc27a4 GeneProduct ncbigene:26569 Original kegg element: gene;36;mmu:26457 mmu:26569
Apoa2 GeneProduct ncbigene:11807 Original kegg element: gene;46;mmu:11807
Cd36 GeneProduct ncbigene:12491 Original kegg element: gene;31;mmu:12491
Slc27a1 GeneProduct ncbigene:26457 Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569
Fabp1 GeneProduct ncbigene:14080 Original kegg element: gene;44;mmu:14080
Me1 GeneProduct ncbigene:17436 Original kegg element: gene;65;mmu:17436
Adipoq GeneProduct ncbigene:11450 Original kegg element: gene;53;mmu:11450
Apoc3 GeneProduct ncbigene:11814 Original kegg element: gene;57;mmu:11814
Acsl5 GeneProduct ncbigene:433256 Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
Fabp4 GeneProduct ncbigene:11770 Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
Ppara GeneProduct ncbigene:19013 Original kegg element: gene;14;mmu:19013
Fads2 GeneProduct ncbigene:56473 Original kegg element: gene;56;mmu:56473
Rxrg GeneProduct ncbigene:20183 Original kegg element: gene;15;mmu:20181 mmu:20182 mmu:20183
Cyp7a1 GeneProduct ncbigene:13122 Original kegg element: gene;33;mmu:13122
Pltp GeneProduct ncbigene:18830 Original kegg element: gene;47;mmu:18830
Gyk GeneProduct ncbigene:14933 Original kegg element: gene;8;mmu:14626 mmu:14933
Primary bile acid biosynthesis GeneProduct kegg.genes:path:mmu00120 Original kegg element: map;51;path:mmu00120
Plin1 GeneProduct ncbigene:103968 Original kegg element: gene;10;mmu:103968
Slc27a5 GeneProduct ncbigene:26459 Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569
Acox3 GeneProduct ncbigene:80911 Original kegg element: gene;42;mmu:11430 mmu:80911 mmu:93732
Apoa5 GeneProduct ncbigene:66113 Original kegg element: gene;64;mmu:66113
Acox2 GeneProduct ncbigene:93732 Original kegg element: gene;42;mmu:11430 mmu:80911 mmu:93732
Pck1 GeneProduct ncbigene:18534 Original kegg element: gene;9;mmu:18534 mmu:74551
Cpt2 GeneProduct ncbigene:12896 Original kegg element: gene;26;mmu:12896
Acsl1 GeneProduct ncbigene:14081 Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
Fabp6 GeneProduct ncbigene:16204 Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
Rxrb GeneProduct ncbigene:20182 Original kegg element: gene;15;mmu:20181 mmu:20182 mmu:20183
Mmp1b GeneProduct ncbigene:83996 Original kegg element: gene;39;mmu:83995 mmu:83996
Olr1 GeneProduct ncbigene:108078 Original kegg element: gene;29;mmu:108078
Slc27a4 GeneProduct ncbigene:26569 Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569
Cyp4a29-ps GeneProduct ncbigene:230639 Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
Cd36 GeneProduct ncbigene:12491 Original kegg element: gene;11;mmu:12491
Mmp1a GeneProduct ncbigene:83995 Original kegg element: gene;39;mmu:83995 mmu:83996
Slc27a6 GeneProduct ncbigene:225579 Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569
Cyp4a30b-ps GeneProduct ncbigene:435802 Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
Acsbg1 GeneProduct ncbigene:94180 Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
Scp2 GeneProduct ncbigene:20280 Original kegg element: gene;20;mmu:20280
Scd1 GeneProduct ncbigene:20249 Original kegg element: gene;55;mmu:20249 mmu:20250 mmu:30049 mmu:329065
cytochrome P450 4A14-like GeneProduct ncbigene:640109 Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
Lpl GeneProduct ncbigene:16956 Original kegg element: gene;30;mmu:16956
Glycerophospholipid metabolism GeneProduct kegg.genes:path:mmu00564 Original kegg element: map;52;path:mmu00564
Ilk GeneProduct ncbigene:16202 Original kegg element: gene;43;mmu:16202
Apoa1 GeneProduct ncbigene:11806 Original kegg element: gene;61;mmu:11806
Gk2 GeneProduct ncbigene:14626 Original kegg element: gene;8;mmu:14626 mmu:14933
Fabp3 GeneProduct ncbigene:14077 Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
Rxrg GeneProduct ncbigene:20183 Original kegg element: gene;17;mmu:20181 mmu:20182 mmu:20183
Cpt1a GeneProduct ncbigene:12894 Original kegg element: gene;27;mmu:12894 mmu:12895 mmu:78070
Rxra GeneProduct ncbigene:20181 Original kegg element: gene;17;mmu:20181 mmu:20182 mmu:20183
Sorbs1 GeneProduct ncbigene:20411 Original kegg element: gene;38;mmu:20411
Fabp4 GeneProduct ncbigene:11770 Original kegg element: gene;40;mmu:11770
Fabp5 GeneProduct ncbigene:16592 Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
Ehhadh GeneProduct ncbigene:74147 Original kegg element: gene;25;mmu:74147
Pdpk1 GeneProduct ncbigene:18607 Original kegg element: gene;45;mmu:18607
Acadl GeneProduct ncbigene:11363 Original kegg element: gene;23;mmu:11363
Acaa1a GeneProduct ncbigene:113868 Original kegg element: gene;21;mmu:113868 mmu:235674

References

  1. PPARs-mediated intracellular signal transduction. Fujii H. Nihon Rinsho. 2005 Apr;63(4):565–71. PubMed Europe PMC Scholia