PPAR signaling pathway (WP2316)

Mus musculus

Open in new tab Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake. Adapted from KEGG: http://www.genome.jp/kegg/pathway/mmu/mmu03320.html

Authors

Thomas Kelder , Daniela Digles , Alex Pico , Kristina Hanspers , Denise Slenter , Friederike Ehrhart , and Felicia Castriota

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Mus musculus

Communities

Annotations

Cell Type Ontology

white fat cell cell of skeletal muscle

Pathway Ontology

peroxisome proliferator-activated receptor signaling pathway transcription factor mediated signaling pathway signaling pathway

Participants

Label Type Compact URI Comment
unsaturated fatty acids Metabolite chebi:27208
saturated fatty acids Metabolite chebi:26607
eicosanoid Metabolite chebi:23899
Ciprofibrate Metabolite wikidata:Q3496452
NSAIDs Metabolite chebi:35475
9-cis-Retinoic acid Metabolite hmdb:HMDB0002369
Thiazolidine derivative Metabolite chebi:35622
Acaa1b GeneProduct ncbigene:235674 Original kegg element: gene;21;mmu:113868 mmu:235674
Ppard GeneProduct ncbigene:19015 Original kegg element: gene;16;mmu:19015
Pparg GeneProduct ncbigene:19016 Original kegg element: gene;18;mmu:19016
Ubc GeneProduct ncbigene:22190 Original kegg element: gene;62;mmu:22190
Pck2 GeneProduct ncbigene:74551 Original kegg element: gene;9;mmu:18534 mmu:74551
Cyp4a31 GeneProduct ncbigene:666168 Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
Cyp8b1 GeneProduct ncbigene:13124 Original kegg element: gene;58;mmu:13124
Ucp1 GeneProduct ncbigene:22227 Original kegg element: gene;66;mmu:22227
Slc27a1 GeneProduct ncbigene:26457 Original kegg element: gene;36;mmu:26457 mmu:26569
Hmgcs2 GeneProduct ncbigene:15360 Original kegg element: gene;37;mmu:15360
Cyp4a10 GeneProduct ncbigene:13117 Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
Rxrb GeneProduct ncbigene:20182 Original kegg element: gene;17;mmu:20181 mmu:20182 mmu:20183
Aqp7 GeneProduct ncbigene:11832 Original kegg element: gene;7;mmu:11832
Scd2 GeneProduct ncbigene:20250 Original kegg element: gene;55;mmu:20249 mmu:20250 mmu:30049 mmu:329065
Acox1 GeneProduct ncbigene:11430 Original kegg element: gene;42;mmu:11430 mmu:80911 mmu:93732
Cyp4a12b GeneProduct ncbigene:13118 Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
Adipocytokine signaling pathway GeneProduct kegg.genes:path:mmu04920 Original kegg element: map;34;path:mmu04920
Scd3 GeneProduct ncbigene:30049 Original kegg element: gene;55;mmu:20249 mmu:20250 mmu:30049 mmu:329065
Scd4 GeneProduct ncbigene:329065 Original kegg element: gene;55;mmu:20249 mmu:20250 mmu:30049 mmu:329065
Nr1h3 GeneProduct ncbigene:22259 Original kegg element: gene;59;mmu:22259
Rxra GeneProduct ncbigene:20181 Original kegg element: gene;19;mmu:20181 mmu:20182 mmu:20183
Acsbg2 GeneProduct ncbigene:328845 Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
Fabp1 GeneProduct ncbigene:14080 Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
Cyp4a14 GeneProduct ncbigene:13119 Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
Rxrg GeneProduct ncbigene:20183 Original kegg element: gene;19;mmu:20181 mmu:20182 mmu:20183
Rxrb GeneProduct ncbigene:20182 Original kegg element: gene;19;mmu:20181 mmu:20182 mmu:20183
Acsl6 GeneProduct ncbigene:216739 Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
Angptl4 GeneProduct ncbigene:57875 Original kegg element: gene;41;mmu:57875
Cyp27a1 GeneProduct ncbigene:104086 Original kegg element: gene;60;mmu:104086
Acsl3 GeneProduct ncbigene:74205 Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
Fabp7 GeneProduct ncbigene:12140 Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
Acadm GeneProduct ncbigene:11364 Original kegg element: gene;22;mmu:11364
Cpt1b GeneProduct ncbigene:12895 Original kegg element: gene;27;mmu:12894 mmu:12895 mmu:78070
Cpt1c GeneProduct ncbigene:78070 Original kegg element: gene;27;mmu:12894 mmu:12895 mmu:78070
Rxra GeneProduct ncbigene:20181 Original kegg element: gene;15;mmu:20181 mmu:20182 mmu:20183
Cyp4a12a GeneProduct ncbigene:277753 Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
Fabp3 GeneProduct ncbigene:14077 Original kegg element: gene;32;mmu:14077
Cyp4a32 GeneProduct ncbigene:100040843 Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
Fabp2 GeneProduct ncbigene:14079 Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
Acsl4 GeneProduct ncbigene:50790 Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
Dbi GeneProduct ncbigene:13167 Original kegg element: gene;63;mmu:13167
Slc27a2 GeneProduct ncbigene:26458 Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569
Slc27a4 GeneProduct ncbigene:26569 Original kegg element: gene;36;mmu:26457 mmu:26569
Apoa2 GeneProduct ncbigene:11807 Original kegg element: gene;46;mmu:11807
Cd36 GeneProduct ncbigene:12491 Original kegg element: gene;31;mmu:12491
Slc27a1 GeneProduct ncbigene:26457 Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569
Fabp1 GeneProduct ncbigene:14080 Original kegg element: gene;44;mmu:14080
Me1 GeneProduct ncbigene:17436 Original kegg element: gene;65;mmu:17436
Adipoq GeneProduct ncbigene:11450 Original kegg element: gene;53;mmu:11450
Apoc3 GeneProduct ncbigene:11814 Original kegg element: gene;57;mmu:11814
Acsl5 GeneProduct ncbigene:433256 Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
Fabp4 GeneProduct ncbigene:11770 Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
Ppara GeneProduct ncbigene:19013 Original kegg element: gene;14;mmu:19013
Fads2 GeneProduct ncbigene:56473 Original kegg element: gene;56;mmu:56473
Rxrg GeneProduct ncbigene:20183 Original kegg element: gene;15;mmu:20181 mmu:20182 mmu:20183
Cyp7a1 GeneProduct ncbigene:13122 Original kegg element: gene;33;mmu:13122
Pltp GeneProduct ncbigene:18830 Original kegg element: gene;47;mmu:18830
Gyk GeneProduct ncbigene:14933 Original kegg element: gene;8;mmu:14626 mmu:14933
Primary bile acid biosynthesis GeneProduct kegg.genes:path:mmu00120 Original kegg element: map;51;path:mmu00120
Plin1 GeneProduct ncbigene:103968 Original kegg element: gene;10;mmu:103968
Slc27a5 GeneProduct ncbigene:26459 Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569
Acox3 GeneProduct ncbigene:80911 Original kegg element: gene;42;mmu:11430 mmu:80911 mmu:93732
Apoa5 GeneProduct ncbigene:66113 Original kegg element: gene;64;mmu:66113
Acox2 GeneProduct ncbigene:93732 Original kegg element: gene;42;mmu:11430 mmu:80911 mmu:93732
Pck1 GeneProduct ncbigene:18534 Original kegg element: gene;9;mmu:18534 mmu:74551
Cpt2 GeneProduct ncbigene:12896 Original kegg element: gene;26;mmu:12896
Acsl1 GeneProduct ncbigene:14081 Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
Fabp6 GeneProduct ncbigene:16204 Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
Rxrb GeneProduct ncbigene:20182 Original kegg element: gene;15;mmu:20181 mmu:20182 mmu:20183
Mmp1b GeneProduct ncbigene:83996 Original kegg element: gene;39;mmu:83995 mmu:83996
Olr1 GeneProduct ncbigene:108078 Original kegg element: gene;29;mmu:108078
Slc27a4 GeneProduct ncbigene:26569 Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569
Cyp4a29-ps GeneProduct ncbigene:230639 Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
Cd36 GeneProduct ncbigene:12491 Original kegg element: gene;11;mmu:12491
Mmp1a GeneProduct ncbigene:83995 Original kegg element: gene;39;mmu:83995 mmu:83996
Slc27a6 GeneProduct ncbigene:225579 Original kegg element: gene;12;mmu:225579 mmu:26457 mmu:26458 mmu:26459 mmu:26569
Cyp4a30b-ps GeneProduct ncbigene:435802 Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
Acsbg1 GeneProduct ncbigene:94180 Original kegg element: gene;28;mmu:14081 mmu:216739 mmu:328845 mmu:433256 mmu:50790 mmu:74205 mmu:94180
Scp2 GeneProduct ncbigene:20280 Original kegg element: gene;20;mmu:20280
Scd1 GeneProduct ncbigene:20249 Original kegg element: gene;55;mmu:20249 mmu:20250 mmu:30049 mmu:329065
cytochrome P450 4A14-like GeneProduct ncbigene:640109 Original kegg element: gene;24;mmu:100040843 mmu:13117 mmu:13118 mmu:13119 mmu:230639 mmu:277753 mmu:435802 mmu:640109 mmu:666168
Lpl GeneProduct ncbigene:16956 Original kegg element: gene;30;mmu:16956
Glycerophospholipid metabolism GeneProduct kegg.genes:path:mmu00564 Original kegg element: map;52;path:mmu00564
Ilk GeneProduct ncbigene:16202 Original kegg element: gene;43;mmu:16202
Apoa1 GeneProduct ncbigene:11806 Original kegg element: gene;61;mmu:11806
Gk2 GeneProduct ncbigene:14626 Original kegg element: gene;8;mmu:14626 mmu:14933
Fabp3 GeneProduct ncbigene:14077 Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
Rxrg GeneProduct ncbigene:20183 Original kegg element: gene;17;mmu:20181 mmu:20182 mmu:20183
Cpt1a GeneProduct ncbigene:12894 Original kegg element: gene;27;mmu:12894 mmu:12895 mmu:78070
Rxra GeneProduct ncbigene:20181 Original kegg element: gene;17;mmu:20181 mmu:20182 mmu:20183
Sorbs1 GeneProduct ncbigene:20411 Original kegg element: gene;38;mmu:20411
Fabp4 GeneProduct ncbigene:11770 Original kegg element: gene;40;mmu:11770
Fabp5 GeneProduct ncbigene:16592 Original kegg element: gene;13;mmu:11770 mmu:12140 mmu:14077 mmu:14079 mmu:14080 mmu:16204 mmu:16592
Ehhadh GeneProduct ncbigene:74147 Original kegg element: gene;25;mmu:74147
Pdpk1 GeneProduct ncbigene:18607 Original kegg element: gene;45;mmu:18607
Acadl GeneProduct ncbigene:11363 Original kegg element: gene;23;mmu:11363
Acaa1a GeneProduct ncbigene:113868 Original kegg element: gene;21;mmu:113868 mmu:235674

References

  1. PPARs-mediated intracellular signal transduction. Fujii H. Nihon Rinsho. 2005 Apr;63(4):565–71. PubMed Europe PMC Scholia