Hedgehog signaling pathway (WP574)

Rattus norvegicus

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The Hedgehog proteins are a family of secreted ligands that include sonic hedgehog, Indian hedgehog and desert hedgehog in humans. Binding of Hedgehog ligands to their receptors, Patched 1 and 2, prevents inhibition of a 7 transmembrane receptor called Smoothened. This leads to activation of GLI family of transcription factors (GLI1-3). Signaling through the Hedgehog pathway is essential for development of many tissues and organs. This pathway is highly conserved among metazoans. Aberrant activation of this pathway has been associated with a number of human malignancies including carcinoma of lung, esophagus, pancreas and prostate. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_10

Authors

Akhilesh Pandey , Alex Pico , Christine Chichester , Martina Summer-Kutmon , and Eric Weitz

Activity

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Organisms

Rattus norvegicus

Communities

Annotations

Pathway Ontology

Hedgehog signaling pathway

Participants

Label Type Compact URI Comment
PTCH2 GeneProduct ncbigene:366452
Shh GeneProduct ncbigene:29499
Cdc2 GeneProduct ncbigene:54237
Ptch1 GeneProduct ncbigene:89830
Dhh GeneProduct ncbigene:84380
Smo GeneProduct ncbigene:25273
Ihh GeneProduct ncbigene:84399
GLI3 GeneProduct ncbigene:140588
Ski GeneProduct ensembl:ENSRNOG00000055340
Sufu GeneProduct ncbigene:361769
Sap18 GeneProduct ncbigene:290284
Sin3a GeneProduct ncbigene:363067
Gli1 GeneProduct ncbigene:140589
GAS1 GeneProduct ncbigene:83818
Crebbp GeneProduct ncbigene:54244
Dyrk1a GeneProduct ncbigene:25255
Gli2 GeneProduct ncbigene:304729
Stk36 GeneProduct ncbigene:301516
Ccnb1 GeneProduct ncbigene:25203
Rab23 GeneProduct ncbigene:367242
Igf2 GeneProduct ncbigene:24483
Hhip GeneProduct ncbigene:291936

References

  1. Requirements for hedgehog, a segmental polarity gene, in patterning larval and adult cuticle of Drosophila. Mohler J. Genetics. 1988 Dec;120(4):1061–72. PubMed Europe PMC Scholia
  2. The Hedgehog response network: sensors, switches, and routers. Lum L, Beachy PA. Science. 2004 Jun 18;304(5678):1755–9. PubMed Europe PMC Scholia