mir219 in oligodendrocyte differentiation and myelination (WP2811)

Rattus norvegicus

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Young and environmentally enriched exosomes deliver functional miR-219 that impacts oligodendrocyte differentiation and myelination. Schematic illustration of the involvement of miR-219 in oligodendrocyte differentiation. Upon exposure to nutritive exosomes, neural stem cells preferentially enter the oligodendrocyte lineage due to the inhibition of the proneurogenic factor NeuroD1. miR-219 also suppresses expression of a number of other factors that inhibit OPC differentiation, such as PDGFRα, a receptor for a mitogenic factor that promotes proliferation and prohibits differentiation. Finally, miR-219 decreases levels of ELOVL7, a regulator of lipid metabolism whose over-activity could lead to demyelination.

Authors

Kristina Hanspers , Alex Pico , Martina Summer-Kutmon , Elisa Cirillo , and Eric Weitz

Activity

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Organisms

Rattus norvegicus

Communities

ExRNA

Annotations

Cell Type Ontology

neuron neuroglioblast (sensu Nematoda and Protostomia)

Pathway Ontology

regulatory pathway

Participants

Label Type Compact URI Comment
Elovl7 GeneProduct ensembl:ENSRNOG00000010450
Foxj3 GeneProduct ensembl:ENSRNOG00000061851
Pdgfra GeneProduct ensembl:ENSRNOG00000002244
Neurod1 GeneProduct ensembl:ENSRNOG00000005609
Zfp238 GeneProduct ensembl:ENSRNOG00000004423
Sox6 GeneProduct ensembl:ENSRNOG00000020514
Hes5 GeneProduct ensembl:ENSRNOG00000013850

References

  1. Dicer ablation in oligodendrocytes provokes neuronal impairment in mice. Shin D, Shin JY, McManus MT, Ptácek LJ, Fu YH. Ann Neurol. 2009 Dec;66(6):843–57. PubMed Europe PMC Scholia
  2. Dicer1 and miR-219 Are required for normal oligodendrocyte differentiation and myelination. Dugas JC, Cuellar TL, Scholze A, Ason B, Ibrahim A, Emery B, et al. Neuron. 2010 Mar 11;65(5):597–611. PubMed Europe PMC Scholia
  3. MicroRNA-mediated control of oligodendrocyte differentiation. Zhao X, He X, Han X, Yu Y, Ye F, Chen Y, et al. Neuron. 2010 Mar 11;65(5):612–26. PubMed Europe PMC Scholia
  4. Youth and environmental enrichment generate serum exosomes containing miR-219 that promote CNS myelination. Pusic AD, Kraig RP. Glia. 2014 Feb;62(2):284–99. PubMed Europe PMC Scholia