Osteoblast signaling (WP238)

Mus musculus

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Osteoblasts are specialized, terminally differentiated uninucleated cells responsible for bone formation. Their activity is tightly regulated by external stimuli, originating from e.g. the parathyroid glands, osteocytes, etc. Along with osteoclasts, which are responsible for bone degradation, osteoblasts are key regulators of the shape and volume of bone tissue.

Authors

Ed Hsiao , Alex Pico , Kristina Hanspers , Daniela Digles , Martina Summer-Kutmon , Andika Tan , and Eric Weitz

Activity

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

signaling pathway pertinent to development

Cell Type Ontology

osteoblast

Participants

Label Type Compact URI Comment
Sodium Metabolite hmdb:HMDB0000588
Phosphate Metabolite hmdb:HMDB0001429
Parathyroid hormone GeneProduct ncbigene:19226
Osteoprotegerin GeneProduct ncbigene:18383
PDGF Ra GeneProduct ncbigene:18595
RANK ligand GeneProduct ncbigene:21943
Bone sialoprotein GeneProduct ncbigene:12907
PTH receptor GeneProduct ncbigene:19228
FGF-23 GeneProduct ncbigene:64654
Collagen 1 GeneProduct ncbigene:12842
NPT3 GeneProduct ncbigene:218103
Osteocalcin GeneProduct ncbigene:12097
PDGF Rb GeneProduct ncbigene:18596

References