Acetaminophen synthesis (WP2886)

Escherichia coli

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Synthetic biology approaches to acetaminophen production. The first reaction path in E.coli has been successfully tested experimentally. The second path in Synechocystis is proposed hypothetically by Menezes, et al. in a study considering synthetic biology approaches to resource utilization on future space missions.

Authors

Alex Pico and Bart Smeets

Activity

last edited

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Organisms

Escherichia coli

Communities

Annotations

Pathway Ontology

paracetamol drug pathway classic metabolic pathway drug pathway

Participants

Label Type Compact URI Comment
4-amino-4-deoxychorismate Metabolite chebi:35181
Chorismate Metabolite hmdb:HMDB0012199
Acetaminophen Metabolite hmdb:HMDB0001859
4-Aminophenol Metabolite hmdb:HMDB0001169
p-Aminobenzoic acid Metabolite hmdb:HMDB0001392
Ammonia Metabolite hmdb:HMDB0000051
Anthranilate Metabolite pubchem.compound:227
pabA GeneProduct ensembl:b3360
nhoA GeneProduct ensembl:b1463
pabB GeneProduct ensembl:b1812
pabC GeneProduct ensembl:b1096
trpE GeneProduct ensembl:b1264

References

  1. A new UV method for serum gamma-glutamyltransferase assay using recombinant 4-aminobenzoate hydroxylase as a coupling enzyme. Mizutani Y, Narikawa T, Satoh T, Sakurai N, Kaji H, Yamada S, et al. J Biochem. 1999 Aug;126(2):347–53. PubMed Europe PMC Scholia
  2. Towards synthetic biological approaches to resource utilization on space missions. Menezes AA, Cumbers J, Hogan JA, Arkin AP. J R Soc Interface. 2015 Jan 6;12(102):20140715. PubMed Europe PMC Scholia