Delta-Notch signaling pathway (WP1180)

Canis familiaris

There are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric proteins and their ligands are also membrane-bound. Signaling through the Notch receptors is triggered by ligand-binding that induces cleavage of the extracellular domain by an ADAM family metalloprotease followed by a cleavage within the transmembrane domain by gamma secretase complex. The second cleavage leads to translocation of the cytosolic domain of Notch receptors into the nucleus. Notch proteins are important in lineage specification and stem cell maintenance. Aberrant Notch signaling has been linked to a number of malignancies including leukemias, lymphomas and carcinomas of the breast, skin, lung, cervix and kidneys. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_3

Authors

Alex Pico , Christine Chichester , and Eric Weitz

Activity

last edited

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Organisms

Canis familiaris

Communities

Annotations

Pathway Ontology

Notch signaling pathway

Participants

Label Type Compact URI Comment
NOTCH1 GeneProduct ncbigene:480676
NOTCH2 GeneProduct ncbigene:483148
NOTCH3 GeneProduct ncbigene:610439
NOTCH4 GeneProduct ncbigene:481726
DLL4 GeneProduct ncbigene:607575
JAG1 GeneProduct ncbigene:485769
LOC490882 GeneProduct ncbigene:490882
PSEN1 GeneProduct ncbigene:403408
PSEN2 GeneProduct ncbigene:490382
APH1A GeneProduct ncbigene:483181
APH1B GeneProduct ncbigene:487589
PSENEN GeneProduct ncbigene:476479
NCSTN GeneProduct ncbigene:488638
ADAM10 GeneProduct ncbigene:478321
ADAM17 GeneProduct ncbigene:475662
GSK3B GeneProduct ncbigene:478575
NUMB GeneProduct ncbigene:480381
ITCH GeneProduct ncbigene:477199
APP GeneProduct ncbigene:403407
NUMBL GeneProduct ncbigene:612491
PIK3R1 GeneProduct ncbigene:487235
PIK3R2 GeneProduct ncbigene:609956
AKT1 GeneProduct ncbigene:490878
FURIN GeneProduct ncbigene:488746
CNTN1 GeneProduct ncbigene:477641
LOC475083 GeneProduct ncbigene:475083
ASCL1 GeneProduct ncbigene:482628
TP53 GeneProduct ncbigene:403869
MFNG GeneProduct ncbigene:610303
POFUT1 GeneProduct ncbigene:609881
SKP1 GeneProduct ncbigene:474682
FBXW7 GeneProduct ncbigene:475465
HEY1 GeneProduct ncbigene:403420
MAML2 GeneProduct ncbigene:485116
MAML3 GeneProduct ncbigene:483814
MAML1 GeneProduct ncbigene:481457
SNW1 GeneProduct ncbigene:480405
NCOR2 GeneProduct ncbigene:486242
NCOR1 GeneProduct ncbigene:479515
LOC487309 GeneProduct ncbigene:487309
LOC478804 GeneProduct ncbigene:478804
SAP30 GeneProduct ncbigene:607359
LOC475035 GeneProduct ncbigene:475035
SIN3A GeneProduct ncbigene:478372
STAT3 GeneProduct ncbigene:490967
JAK2 GeneProduct ncbigene:484185
RELA GeneProduct ncbigene:483729
NFKBIA GeneProduct ncbigene:480291
TLE1 GeneProduct ncbigene:476314
SMAD3 GeneProduct ncbigene:610902
SMAD4 GeneProduct ncbigene:476196
YY1 GeneProduct ncbigene:611171
CDK2 GeneProduct ncbigene:606931
LEF1 GeneProduct ncbigene:478507
MEF2C GeneProduct ncbigene:479155
CUL1 GeneProduct ncbigene:475512
SKP2 GeneProduct ncbigene:489228
RBX1 GeneProduct ncbigene:474494
TCF3 GeneProduct ncbigene:485079
MAPK3 GeneProduct ncbigene:486758
MAPK1 GeneProduct ncbigene:477575
WDR12 GeneProduct ncbigene:478876
KAT2B GeneProduct ncbigene:477052
FHL1 GeneProduct ncbigene:492162
RING1 GeneProduct ncbigene:607905
SMAD1 GeneProduct ncbigene:475456
HES6 GeneProduct ncbigene:607298
GATA1 GeneProduct ncbigene:480906
CNTFR GeneProduct ncbigene:442941
CNTF GeneProduct ncbigene:483464
HES5 GeneProduct ncbigene:489614
LCK GeneProduct ncbigene:478151
JUN GeneProduct ncbigene:609429
RBPJ GeneProduct ncbigene:479122
EGF GeneProduct ncbigene:403657
EGFR GeneProduct ncbigene:404306

References