Hedgehog signaling pathway (WP116)

Mus musculus

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The Hedgehog proteins are a family of secreted ligands that include sonic hedgehog, Indian hedgehog and desert hedgehog in humans. Binding of Hedgehog ligands to their receptors, Patched 1 and 2, prevents inhibition of a 7 transmembrane receptor called Smoothened. This leads to activation of GLI family of transcription factors (GLI1-3). Signaling through the Hedgehog pathway is essential for development of many tissues and organs. This pathway is highly conserved among metazoans. Aberrant activation of this pathway has been associated with a number of human malignancies including carcinoma of lung, esophagus, pancreas and prostate. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_10

Authors

Akhilesh Pandey , Alex Pico , Christine Chichester , Lauren J. Dupuis , and Eric Weitz

Activity

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

Hedgehog signaling pathway

Participants

Label Type Compact URI Comment
Gli1 GeneProduct ncbigene:14632
Sufu GeneProduct ncbigene:24069
Dyrk1a GeneProduct ncbigene:13548
Ihh GeneProduct ncbigene:16147
Gas1 GeneProduct ncbigene:14451
CCNB1 GeneProduct ncbigene:268697
Ptch2 GeneProduct ncbigene:19207
Dhh GeneProduct ncbigene:13363
Crebbp GeneProduct ncbigene:12914
Cdc2a GeneProduct ncbigene:12534
Gli3 GeneProduct ncbigene:14634
Hhip GeneProduct ncbigene:15245
Ptch1 GeneProduct ncbigene:19206
Shh GeneProduct ncbigene:20423
Igf2 GeneProduct ncbigene:16002
Ski GeneProduct ncbigene:20481
Rab23 GeneProduct ncbigene:19335
Stk36 GeneProduct ncbigene:269209
Smo GeneProduct ncbigene:319757
SAP18 GeneProduct ncbigene:20220
Gli2 GeneProduct ncbigene:14633
Sin3a GeneProduct ncbigene:20466

References

  1. Requirements for hedgehog, a segmental polarity gene, in patterning larval and adult cuticle of Drosophila. Mohler J. Genetics. 1988 Dec;120(4):1061–72. PubMed Europe PMC Scholia
  2. The Hedgehog response network: sensors, switches, and routers. Lum L, Beachy PA. Science. 2004 Jun 18;304(5678):1755–9. PubMed Europe PMC Scholia