Semaphorin interactions (WP3151)

Bos taurus

Authors

Martina Summer-Kutmon , Linda Rieswijk , and Alex Pico

Activity

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Organisms

Bos taurus

Communities

Annotations

Pathway Ontology

signaling pathway

References

1. Kiz-1, a protein with LIM zinc finger and kinase domains, is expressed mainly in neurons. Bernard O, Ganiatsas S, Kannourakis G, Dringen R. Cell Growth Differ. 1994 Nov;5(11):1159–71. PubMed Europe PMC Scholia
2. The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase. Ishizaki T, Maekawa M, Fujisawa K, Okawa K, Iwamatsu A, Fujita A, et al. EMBO J. 1996 Apr 15;15(8):1885–93. PubMed Europe PMC Scholia
3. CD100 is associated with CD45 at the surface of human T lymphocytes. Role in T cell homotypic adhesion. Herold C, Elhabazi A, Bismuth G, Bensussan A, Boumsell L. J Immunol. 1996 Dec 15;157(12):5262–8. PubMed Europe PMC Scholia
4. Multisite autophosphorylation of p21-activated protein kinase gamma-PAK as a function of activation. Gatti A, Huang Z, Tuazon PT, Traugh JA. J Biol Chem. 1999 Mar 19;274(12):8022–8. PubMed Europe PMC Scholia
5. Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, et al. Cell. 1999 Oct 1;99(1):71–80. PubMed Europe PMC Scholia
6. Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. Edwards DC, Sanders LC, Bokoch GM, Gill GN. Nat Cell Biol. 1999 Sep;1(5):253–9. PubMed Europe PMC Scholia
7. Switch in the protein tyrosine phosphatase associated with human CD100 semaphorin at terminal B-cell differentiation stage. Billard C, Delaire S, Raffoux E, Bensussan A, Boumsell L. Blood. 2000 Feb 1;95(3):965–72. PubMed Europe PMC Scholia
8. Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop. Ohashi K, Nagata K, Maekawa M, Ishizaki T, Narumiya S, Mizuno K. J Biol Chem. 2000 Feb 4;275(5):3577–82. PubMed Europe PMC Scholia
9. Semaphorins and their receptors in vertebrates and invertebrates. Raper JA. Curr Opin Neurobiol. 2000 Feb;10(1):88–94. PubMed Europe PMC Scholia
10. Molecular basis of semaphorin-mediated axon guidance. Nakamura F, Kalb RG, Strittmatter SM. J Neurobiol. 2000 Aug;44(2):219–29. PubMed Europe PMC Scholia
11. Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase. Sumi T, Matsumoto K, Nakamura T. J Biol Chem. 2001 Jan 5;276(1):670–6. PubMed Europe PMC Scholia
12. The semaphorin receptor plexin-B1 specifically interacts with active Rac in a ligand-dependent manner. Vikis HG, Li W, He Z, Guan KL. Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12457–62. PubMed Europe PMC Scholia
13. Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling. Kumanogoh A, Watanabe C, Lee I, Wang X, Shi W, Araki H, et al. Immunity. 2000 Nov;13(5):621–31. PubMed Europe PMC Scholia
14. Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse. Aizawa H, Wakatsuki S, Ishii A, Moriyama K, Sasaki Y, Ohashi K, et al. Nat Neurosci. 2001 Apr;4(4):367–73. PubMed Europe PMC Scholia
15. The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity. Chong C, Tan L, Lim L, Manser E. J Biol Chem. 2001 May 18;276(20):17347–53. PubMed Europe PMC Scholia
16. Plexin signaling via off-track and rho family GTPases. Whitford KL, Ghosh A. Neuron. 2001 Oct 11;32(1):1–3. PubMed Europe PMC Scholia
17. The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding. Vikis HG, Li W, Guan KL. Genes Dev. 2002 Apr 1;16(7):836–45. PubMed Europe PMC Scholia
18. Involvement of Fes/Fps tyrosine kinase in semaphorin3A signaling. Mitsui N, Inatome R, Takahashi S, Goshima Y, Yamamura H, Yanagi S. EMBO J. 2002 Jul 1;21(13):3274–85. PubMed Europe PMC Scholia
19. The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG. Aurandt J, Vikis HG, Gutkind JS, Ahn N, Guan KL. Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12085–90. PubMed Europe PMC Scholia
20. The semaphorin 4D receptor controls invasive growth by coupling with Met. Giordano S, Corso S, Conrotto P, Artigiani S, Gilestro G, Barberis D, et al. Nat Cell Biol. 2002 Sep;4(9):720–4. PubMed Europe PMC Scholia
21. Interaction of plexin-B1 with PDZ domain-containing Rho guanine nucleotide exchange factors. Hirotani M, Ohoka Y, Yamamoto T, Nirasawa H, Furuyama T, Kogo M, et al. Biochem Biophys Res Commun. 2002 Sep 13;297(1):32–7. PubMed Europe PMC Scholia
22. Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex. Sasaki Y, Cheng C, Uchida Y, Nakajima O, Ohshima T, Yagi T, et al. Neuron. 2002 Aug 29;35(5):907–20. PubMed Europe PMC Scholia
23. Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions. Ling K, Doughman RL, Firestone AJ, Bunce MW, Anderson RA. Nature. 2002 Nov 7;420(6911):89–93. PubMed Europe PMC Scholia
24. Molecular mechanisms of axon guidance. Dickson BJ. Science. 2002 Dec 6;298(5600):1959–64. PubMed Europe PMC Scholia
25. Semaphorin junction: making tracks toward neural connectivity. Pasterkamp RJ, Kolodkin AL. Curr Opin Neurobiol. 2003 Feb;13(1):79–89. PubMed Europe PMC Scholia
26. Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells. Oinuma I, Katoh H, Harada A, Negishi M. J Biol Chem. 2003 Jul 11;278(28):25671–7. PubMed Europe PMC Scholia
27. Involvement of CD100, a lymphocyte semaphorin, in the activation of the human immune system via CD72: implications for the regulation of immune and inflammatory responses. Ishida I, Kumanogoh A, Suzuki K, Akahani S, Noda K, Kikutani H. Int Immunol. 2003 Aug;15(8):1027–34. PubMed Europe PMC Scholia
28. Structural bases for CRMP function in plexin-dependent semaphorin3A signaling. Deo RC, Schmidt EF, Elhabazi A, Togashi H, Burley SK, Strittmatter SM. EMBO J. 2004 Jan 14;23(1):9–22. PubMed Europe PMC Scholia
29. Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2. Swiercz JM, Kuner R, Offermanns S. J Cell Biol. 2004 Jun 21;165(6):869–80. PubMed Europe PMC Scholia
30. Plexin-B3 is a functional receptor for semaphorin 5A. Artigiani S, Conrotto P, Fazzari P, Gilestro GF, Barberis D, Giordano S, et al. EMBO Rep. 2004 Jul;5(7):710–4. PubMed Europe PMC Scholia
31. Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins. Gu C, Yoshida Y, Livet J, Reimert DV, Mann F, Merte J, et al. Science. 2005 Jan 14;307(5707):265–8. PubMed Europe PMC Scholia
32. GSK-3beta regulates phosphorylation of CRMP-2 and neuronal polarity. Yoshimura T, Kawano Y, Arimura N, Kawabata S, Kikuchi A, Kaibuchi K. Cell. 2005 Jan 14;120(1):137–49. PubMed Europe PMC Scholia
33. Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer’s disease. Uchida Y, Ohshima T, Sasaki Y, Suzuki H, Yanai S, Yamashita N, et al. Genes Cells. 2005 Feb;10(2):165–79. PubMed Europe PMC Scholia
34. p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signalling. Barberis D, Casazza A, Sordella R, Corso S, Artigiani S, Settleman J, et al. J Cell Sci. 2005 Oct 15;118(Pt 20):4689–700. PubMed Europe PMC Scholia
35. FARP2 triggers signals for Sema3A-mediated axonal repulsion. Toyofuku T, Yoshida J, Sugimoto T, Zhang H, Kumanogoh A, Hori M, et al. Nat Neurosci. 2005 Dec;8(12):1712–9. PubMed Europe PMC Scholia
36. Hsp90 increases LIM kinase activity by promoting its homo-dimerization. Li R, Soosairajah J, Harari D, Citri A, Price J, Ng HL, et al. FASEB J. 2006 Jun;20(8):1218–20. PubMed Europe PMC Scholia
37. Semaphorin 4D/Plexin-B1-mediated R-Ras GAP activity inhibits cell migration by regulating beta(1) integrin activity. Oinuma I, Katoh H, Negishi M. J Cell Biol. 2006 May 22;173(4):601–13. PubMed Europe PMC Scholia
38. Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis. Takegahara N, Takamatsu H, Toyofuku T, Tsujimura T, Okuno T, Yukawa K, et al. Nat Cell Biol. 2006 Jun;8(6):615–22. PubMed Europe PMC Scholia
39. Sema4D/plexin-B1 activates GSK-3beta through R-Ras GAP activity, inducing growth cone collapse. Ito Y, Oinuma I, Katoh H, Kaibuchi K, Negishi M. EMBO Rep. 2006 Jul;7(7):704–9. PubMed Europe PMC Scholia
40. Repulsion or adhesion: receptors make the call. Halloran MC, Wolman MA. Curr Opin Cell Biol. 2006 Oct;18(5):533–40. PubMed Europe PMC Scholia
41. Semaphorins in axon regeneration: developmental guidance molecules gone wrong? Pasterkamp RJ, Verhaagen J. Philos Trans R Soc Lond B Biol Sci. 2006 Sep 29;361(1473):1499–511. PubMed Europe PMC Scholia
42. Lim kinases, regulators of actin dynamics. Bernard O. Int J Biochem Cell Biol. 2007;39(6):1071–6. PubMed Europe PMC Scholia
43. Semaphorin-4A, an activator for T-cell-mediated immunity, suppresses angiogenesis via Plexin-D1. Toyofuku T, Yabuki M, Kamei J, Kamei M, Makino N, Kumanogoh A, et al. EMBO J. 2007 Mar 7;26(5):1373–84. PubMed Europe PMC Scholia
44. The CRMP family of proteins and their role in Sema3A signaling. Schmidt EF, Strittmatter SM. Adv Exp Med Biol. 2007;600:1–11. PubMed Europe PMC Scholia
45. Intracellular kinases in semaphorin signaling. Ahmed A, Eickholt BJ. Adv Exp Med Biol. 2007;600:24–37. PubMed Europe PMC Scholia
46. ErbB-2 and met reciprocally regulate cellular signaling via plexin-B1. Swiercz JM, Worzfeld T, Offermanns S. J Biol Chem. 2008 Jan 25;283(4):1893–901. PubMed Europe PMC Scholia
47. Role of semaphorins during axon growth and guidance. Koncina E, Roth L, Gonthier B, Bagnard D. Adv Exp Med Biol. 2007;621:50–64. PubMed Europe PMC Scholia
48. Semaphorin signaling: progress made and promises ahead. Zhou Y, Gunput RAF, Pasterkamp RJ. Trends Biochem Sci. 2008 Apr;33(4):161–70. PubMed Europe PMC Scholia