Myometrial relaxation and contraction pathways (WP385)

Mus musculus

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This pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile activity is the myometrium. Genes in this pathway are either transcribed in myometrial muscle cells or act upon the myometrium to regulate contraction. The left half of this pathway illustrates pathways of myometrial relaxation that are active throughout normal gestation. These signaling events act to suppress coordinated contractions to prevent the early onset of labor at term, largely via activation of the adenylyl-cyclase thrhough G-protein coupled receptors. On the right side of this pathway are signaling componets involved in the activation of uterine contractions at labor, in particular, activation of calcium mobilization via Oxytocin mediated binding to the Oxytocin G-protein coupled receptor. Additional genes implicated in this pathway, based on microarray expression profiling of gestation, term and postpartum of term mice are also included (e.g., Guca2b, Rdc1, Edg2) have also been included. For a detailed description of this pathway see: http://genomebiology.com/2005/6/2/R12.

Authors

Nathan Salomonis , Kristina Hanspers , Thomas Kelder , Martijn Van Iersel , Martina Summer-Kutmon , Alex Pico , Elisa Cirillo , Lauren J. Dupuis , Friederike Ehrhart , and Eric Weitz

Activity

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Organisms

Mus musculus

Communities

Annotations

Pathway Ontology

signaling pathway

Cell Type Ontology

smooth muscle cell

Participants

Label Type Compact URI Comment
ATP Metabolite cas:1927-31-7
Cyclic AMP Metabolite hmdb:HMDB0000058
ADP Metabolite cas:58-64-0
Cyclic GMP Metabolite hmdb:HMDB0001314
ADP Metabolite cas:58-64-0
ATP Metabolite cas:1927-31-7
Cyclic AMP Metabolite hmdb:HMDB0000058
Ramp1 GeneProduct ensembl:ENSMUSG00000034353 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10267
Igfbp6 GeneProduct ensembl:ENSMUSG00000023046 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3489
Gng13 GeneProduct ensembl:ENSMUSG00000025739 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:51764
Rgs11 GeneProduct ensembl:ENSMUSG00000024186 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8786
Prkcz GeneProduct ensembl:ENSMUSG00000029053 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5590
Adcy5 GeneProduct ensembl:ENSMUSG00000022840 There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:111
Ryr1 GeneProduct ensembl:ENSMUSG00000030592 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6261
Atp2a3 GeneProduct ensembl:ENSMUSG00000020788 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:489
Atf4 GeneProduct ensembl:ENSMUSG00000042406 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:468
Prkar2b GeneProduct ensembl:ENSMUSG00000002997 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5577
Prkcg GeneProduct ensembl:ENSMUSG00000078816 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5582
Adcy2 GeneProduct ensembl:ENSMUSG00000021536 There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:108
Prkce GeneProduct ensembl:ENSMUSG00000045038 This EST is listed on the Affymetrix Murine6500 chip. The SwissProt entry name is KPCE MOUSE.
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5581
Igfbp5 GeneProduct ensembl:ENSMUSG00000026185 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3488
Grk4 GeneProduct ensembl:ENSMUSG00000052783 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2868
Gnb3 GeneProduct ensembl:ENSMUSG00000023439 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2784
Gng3 GeneProduct ensembl:ENSMUSG00000071658 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2785
Pkib GeneProduct ensembl:ENSMUSG00000019876 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5570
Fos GeneProduct ensembl:ENSMUSG00000021250 PMID: 10218980 PMID: 7628395 [
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2353
Grk5 GeneProduct ensembl:ENSMUSG00000003228 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2869
Oxtr GeneProduct ensembl:ENSMUSG00000049112 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5021
Mylk2 GeneProduct ensembl:ENSMUSG00000027470 KML2 MOUSE
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:85366
Gng12 GeneProduct ensembl:ENSMUSG00000036402 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:55970
Rgs2 GeneProduct ensembl:ENSMUSG00000026360 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5997
Gng2 GeneProduct ensembl:ENSMUSG00000043004 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:54331
Rgs6 GeneProduct ensembl:ENSMUSG00000021219 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:9628
Jun GeneProduct ensembl:ENSMUSG00000052684 PMID: 10218980
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3725
Adcy3 GeneProduct ensembl:ENSMUSG00000020654 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:109
Gng7 GeneProduct ensembl:ENSMUSG00000048240 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2788
Prkacb GeneProduct ensembl:ENSMUSG00000005034 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5567
Atf6b GeneProduct ensembl:ENSMUSG00000015461 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1388
Ramp2 GeneProduct ensembl:ENSMUSG00000001240 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10266
Gpr182 GeneProduct ensembl:ENSMUSG00000058396 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:11318
Calca GeneProduct ensembl:ENSMUSG00000030669 CRF HUMAN PMID: 11854458
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:796
Adcy8 GeneProduct ensembl:ENSMUSG00000022376 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:114
Adcy1 GeneProduct ensembl:ENSMUSG00000020431 CYA1 HUMAN
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:107
Arrb2 GeneProduct ensembl:ENSMUSG00000060216 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:409
Atf1 GeneProduct ensembl:ENSMUSG00000023027 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:466
Nos1 GeneProduct ensembl:ENSMUSG00000029361 PMID: 11854458
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4842
Grk5 GeneProduct ensembl:ENSMUSG00000003228 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2869
Rgs17 GeneProduct ensembl:ENSMUSG00000019775 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:26575
Prkch GeneProduct ensembl:ENSMUSG00000021108 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5583
Ryr2 GeneProduct ensembl:ENSMUSG00000021313 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6262
Rgs18 GeneProduct ensembl:ENSMUSG00000026357 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:64407
Ywhab GeneProduct ensembl:ENSMUSG00000018326 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7529
Il6 GeneProduct ensembl:ENSMUSG00000025746 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3569
Grk6 GeneProduct ensembl:ENSMUSG00000074886 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2870
Crcp GeneProduct ensembl:ENSMUSG00000025532 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:27297
Rxfp1 GeneProduct ensembl:ENSMUSG00000034009 PMID: 11809971
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:59350
Cnn1 GeneProduct ensembl:ENSMUSG00000001349 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1264
Ywhah GeneProduct ensembl:ENSMUSG00000018965 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7533
Camk2g GeneProduct ensembl:ENSMUSG00000021820 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:818
Rgs7 GeneProduct ensembl:ENSMUSG00000026527 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6000
Myl4 GeneProduct ensembl:ENSMUSG00000061086 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4635
Rgs1 GeneProduct ensembl:ENSMUSG00000026358 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5996
Prkcb GeneProduct ensembl:ENSMUSG00000052889 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5579
Mylk2 GeneProduct ensembl:ENSMUSG00000027470 KML2 MOUSE
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:85366
Lpar1 GeneProduct ensembl:ENSMUSG00000038668 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1902
Ramp3 GeneProduct ensembl:ENSMUSG00000041046 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10268
Camk2d GeneProduct ensembl:ENSMUSG00000053819 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:817
Prkcq GeneProduct ensembl:ENSMUSG00000026778 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5588
Nos3 GeneProduct ensembl:ENSMUSG00000028978 PMID: 11854458
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4846
Cald1 GeneProduct ensembl:ENSMUSG00000029761 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:800
Gsto1 GeneProduct ensembl:ENSMUSG00000025068 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:9446
Crh GeneProduct ensembl:ENSMUSG00000049796 CRF HUMAN PMID: 11854458
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1392
Prkca GeneProduct ensembl:ENSMUSG00000050965 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5578
Ywhaz GeneProduct ensembl:ENSMUSG00000022285 PMID: 9861170 PMID: 1317796
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7534
Grk4 GeneProduct ensembl:ENSMUSG00000052783 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2868
Prkar2a GeneProduct ensembl:ENSMUSG00000032601 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5576
Arrb2 GeneProduct ensembl:ENSMUSG00000060216 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:409
Gnb2 GeneProduct ensembl:ENSMUSG00000029713 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2783
Gng11 GeneProduct ensembl:ENSMUSG00000032766 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2791
Oxtr GeneProduct ensembl:ENSMUSG00000049112 Sladek SM, Westerhausen-Larson A, Roberts JM. PMID: 10377025
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5021
Igfbp4 GeneProduct ensembl:ENSMUSG00000017493 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3487
Ryr3 GeneProduct ensembl:ENSMUSG00000057378 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6263
Rgs10 GeneProduct ensembl:ENSMUSG00000030844 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6001
Dgkz GeneProduct ensembl:ENSMUSG00000040479 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8525
Rgs5 GeneProduct ensembl:ENSMUSG00000026678 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8490
Atp2a2 GeneProduct ensembl:ENSMUSG00000029467 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:488
Igfbp2 GeneProduct ensembl:ENSMUSG00000039323 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3485
Rgs20 GeneProduct ensembl:ENSMUSG00000002459 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8601
Gnaq GeneProduct ensembl:ENSMUSG00000024639 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2776
Gnb5 GeneProduct ensembl:ENSMUSG00000032192 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10681
Ywhae GeneProduct ensembl:ENSMUSG00000020849 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7531
Oxt GeneProduct ensembl:ENSMUSG00000027301 MGI:97453
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5020
Prkar1a GeneProduct ensembl:ENSMUSG00000020612 KAP0 HUMAN
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5573
Rgs9 GeneProduct ensembl:ENSMUSG00000020599 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:8787
Sfn GeneProduct ensembl:ENSMUSG00000047281 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2810
Adcy7 GeneProduct ensembl:ENSMUSG00000031659 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:113
Atf5 GeneProduct ensembl:ENSMUSG00000038539 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:22809
Plcg2 GeneProduct ensembl:ENSMUSG00000034330 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5336
Il1b GeneProduct ensembl:ENSMUSG00000027398 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3553
Gng5 GeneProduct ensembl:ENSMUSG00000068523 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2787
Adm GeneProduct ensembl:ENSMUSG00000030790 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:133
Rgs16 GeneProduct ensembl:ENSMUSG00000026475 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6004
Itpr3 GeneProduct ensembl:ENSMUSG00000042644 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3710
Prkd1 GeneProduct ensembl:ENSMUSG00000002688 KPCM HUMAN
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5587
Actg1 GeneProduct ensembl:ENSMUSG00000062825 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:71
Gng8 GeneProduct ensembl:ENSMUSG00000063594 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:94235
Rxfp2 GeneProduct ensembl:ENSMUSG00000053368 PMID: 11809971 LGR8 MOUSE
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:122042
Gnb4 GeneProduct ensembl:ENSMUSG00000027669 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:59345
Prkar1b GeneProduct ensembl:ENSMUSG00000025855 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5575
Rgs19 GeneProduct ensembl:ENSMUSG00000002458 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10287
Actb GeneProduct ensembl:ENSMUSG00000029580 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:60
Corin GeneProduct ensembl:ENSMUSG00000005220 MGI:97367
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10699
Gabpb1 GeneProduct ensembl:ENSMUSG00000027361 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2553
Prkcd GeneProduct ensembl:ENSMUSG00000021948 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5580
Sp1 GeneProduct ensembl:ENSMUSG00000001280 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6667
Gabpa GeneProduct ensembl:ENSMUSG00000008976 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2551
Adcy6 GeneProduct ensembl:ENSMUSG00000022994 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:112
Guca2a GeneProduct ensembl:ENSMUSG00000023247 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2980
Itpr1 GeneProduct ensembl:ENSMUSG00000030102 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3708
Camk2b GeneProduct ensembl:ENSMUSG00000057897 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:816
Crhr1 GeneProduct ensembl:ENSMUSG00000018634 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1394
Rln1 GeneProduct ensembl:ENSMUSG00000039097 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6013
Pde4d GeneProduct ensembl:ENSMUSG00000021699 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5144
Grk6 GeneProduct ensembl:ENSMUSG00000074886 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2870
Ets2 GeneProduct ensembl:ENSMUSG00000022895 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2114
Atf3 GeneProduct ensembl:ENSMUSG00000026628 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:467
Adcy4 GeneProduct ensembl:ENSMUSG00000022220 There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:196883
Plcd1 GeneProduct ensembl:ENSMUSG00000010660 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5333
Rgs4 GeneProduct ensembl:ENSMUSG00000038530 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5999
Rgs14 GeneProduct ensembl:ENSMUSG00000052087 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10636
Slc8a1 GeneProduct ensembl:ENSMUSG00000054640 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:6546
Guca2b GeneProduct ensembl:ENSMUSG00000032978 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2981
Arrb1 GeneProduct ensembl:ENSMUSG00000018909 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:408
Gja1 GeneProduct ensembl:ENSMUSG00000050953 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2697
Arrb1 GeneProduct ensembl:ENSMUSG00000018909 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:408
Ywhag GeneProduct ensembl:ENSMUSG00000051391 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:7532
Cacnb3 GeneProduct ensembl:ENSMUSG00000003352 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:784
Ackr3 GeneProduct ensembl:ENSMUSG00000044337 PMID: 10614663
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:57007
Igfbp1 GeneProduct ensembl:ENSMUSG00000020429 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3484
Pkig GeneProduct ensembl:ENSMUSG00000035268 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:11142
Pde4b GeneProduct ensembl:ENSMUSG00000028525 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5142
Gngt1 GeneProduct ensembl:ENSMUSG00000029663 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2792
Pkia GeneProduct ensembl:ENSMUSG00000027499 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5569
Ywhaq GeneProduct ensembl:ENSMUSG00000076432 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10971
Creb3 GeneProduct ensembl:ENSMUSG00000028466 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:10488
Actc1 GeneProduct ensembl:ENSMUSG00000068614 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:70
Igfbp3 GeneProduct ensembl:ENSMUSG00000020427 Relaxin is a member of the Insulin Growth Factor family of proteins. IGFBP-3 binds IGFII preferentially. (SwissProt).
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3486
Plcg1 GeneProduct ensembl:ENSMUSG00000016933 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5335
Gnas GeneProduct ensembl:ENSMUSG00000027523 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2778
Maff GeneProduct ensembl:ENSMUSG00000042622 OMIM: Inoue et al. (1994) demonstrated that the US-2 element in the promoter of the human oxytocin receptor gene (OXTR; 167055) binds specifically nuclear proteins from human myometrium at parturition. Using the US-2 element in a yeast 1-hybrid system to screen a human myometrium cDNA library, Kimura et al. (1999) isolated a full-length cDNA encoding the homolog of chicken MafF. Human MAFF encodes a deduced 164-amino acid protein with a predicted molecular mass of 17.8 kD. Like other small MAF proteins (e.g., MAFG, 602020), it contains an extended leucine zipper structure and lacks an N-terminal transactivating domain. Northern blot analysis showed a strong 2.6-kb signal in mRNA from term myometrium and from kidney, but not from nonpregnant myometrium. The MAFF protein is also preferentially expressed in term myometrium. The authors concluded that MAFF plays a role in OXTR gene upregulation at term.
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:23764
Calm3 GeneProduct ensembl:ENSMUSG00000019370 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:808
Atf2 GeneProduct ensembl:ENSMUSG00000027104 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1386
Gng4 GeneProduct ensembl:ENSMUSG00000021303 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2786
Adcy9 GeneProduct ensembl:ENSMUSG00000005580 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:115
Acta1 GeneProduct ensembl:ENSMUSG00000031972 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:58
Gnb1 GeneProduct ensembl:ENSMUSG00000029064 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2782
Myl2 GeneProduct ensembl:ENSMUSG00000013936 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4633
Rgs3 GeneProduct ensembl:ENSMUSG00000059810 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5998
Itpr2 GeneProduct ensembl:ENSMUSG00000030287 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:3709
Plcb3 GeneProduct ensembl:ENSMUSG00000024960 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:5331
Camk2a GeneProduct ensembl:ENSMUSG00000024617 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:815
Nfkb1 GeneProduct ensembl:ENSMUSG00000028163 Localization of regulatory protein binding sites in the proximal region of human myometrial connexin 43 gene. Echetebu CO, Ali M, Izban MG, MacKay L, Garfield RE. PMID: 10421804
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:4790
Creb1 GeneProduct ensembl:ENSMUSG00000025958 Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:1385
Gucy1a3 GeneProduct ensembl:ENSMUSG00000033910 PMID: 11854458
Homology Mapping from Homo sapiens to Mus musculus: Original ID = L:2982

References

  1. Is up-regulation of phosphodiesterase 4 activity by PGE2 involved in the desensitization of beta-mimetics in late pregnancy human myometrium? Méhats C, Tanguy G, Dallot E, Cabrol D, Ferré F, Leroy MJ. J Clin Endocrinol Metab. 2001 Nov;86(11):5358–65. PubMed Europe PMC Scholia
  2. Up-regulation of nitric oxide synthase and modulation of the guanylate cyclase activity by corticotropin-releasing hormone but not urocortin II or urocortin III in cultured human pregnant myometrial cells. Aggelidou E, Hillhouse EW, Grammatopoulos DK. Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3300–5. PubMed Europe PMC Scholia
  3. Identifying genetic networks underlying myometrial transition to labor. Salomonis N, Cotte N, Zambon AC, Pollard KS, Vranizan K, Doniger SW, et al. Genome Biol. 2005;6(2):R12. PubMed Europe PMC Scholia