This is the ONTOX project's community at WikiPathways
The ONTOX Community aims to list and highlight molecular interaction pathways related to hepato-, nephro-, and neurodevelopmental toxicities. This collection is curated and maintained by biocurators and domain experts from the ONTOX project. The community features pathways involved in organ-specific toxicity responses. All pathway lists and related resources are publicly available and can be downloaded from dedicated GitHub repositories, with separate lists maintained for hepatotoxicity, nephrotoxicity, and neurodevelopmental toxicity pathways https://github.com/ontox-maps/ontox_wikipathways.
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ONTOX collection
Community Pathways
Table FiltersThis community helps to curate 409 pathways:
- 10q11.21q11.23 copy number variation syndrome - WP5352 (Homo sapiens)
- 10q22q23 copy number variation - WP5402 (Homo sapiens)
- 11p11.2 copy number variation syndrome - WP5348 (Homo sapiens)
- 13q12.12 copy number variation - WP5406 (Homo sapiens)
- 15q11.2 copy number variation syndrome - WP4940 (Homo sapiens)
- 15q11q13 copy number variation - WP5407 (Homo sapiens)
- 15q13.3 copy number variation syndrome - WP4942 (Homo sapiens)
- 15q25 copy number variation - WP5408 (Homo sapiens)
- 16p11.2 distal deletion syndrome - WP4950 (Homo sapiens)
- 16p11.2 proximal deletion syndrome - WP4949 (Homo sapiens)
- 17p13.3 (YWHAE) copy number variation - WP5376 (Homo sapiens)
- 17q12 copy number variation syndrome - WP5287 (Homo sapiens)
- 1p36 copy number variation syndrome - WP5345 (Homo sapiens)
- 1q21.1 copy number variation syndrome - WP4905 (Homo sapiens)
- 22q11.2 copy number variation syndrome - WP4657 (Homo sapiens)
- 2q11.2 copy number variation syndrome - WP5221 (Homo sapiens)
- 2q13 copy number variation syndrome - WP5222 (Homo sapiens)
- 2q21.1 copy number variation syndrome - WP5223 (Homo sapiens)
- 2q37 copy number variation syndrome - WP5224 (Homo sapiens)
- 3q29 copy number variation syndrome - WP4906 (Homo sapiens)
- 4-hydroxytamoxifen, dexamethasone, and retinoic acids regulation of p27 expression - WP3879 (Homo sapiens)
- 4p16.3 copy number variation - WP5365 (Homo sapiens)
- 5q35 copy number variation - WP5380 (Homo sapiens)
- 6q16 copy number variation - WP5400 (Homo sapiens)
- 7-oxo-C and 7-beta-HC pathways - WP5064 (Homo sapiens)
- 7q11.23 copy number variation syndrome - WP4932 (Homo sapiens)
- 7q11.23 distal copy number variation - WP5401 (Homo sapiens)
- 8p23.1 copy number variation syndrome - WP5346 (Homo sapiens)
- ACE inhibitor pathway - WP554 (Homo sapiens)
- ACE2 inhibition leads to pulmonary fibrosis - WP5035 (Homo sapiens)
- ADHD and autism (ASD) pathways - WP5420 (Homo sapiens)
- AGE/RAGE pathway - WP2324 (Homo sapiens)
- ALA oxylipin metabolism - WP5136 (Homo sapiens)
- AMP-activated protein kinase signaling - WP1403 (Homo sapiens)
- ATM signaling - WP2516 (Homo sapiens)
- ATM signaling in development and disease - WP3878 (Homo sapiens)
- ATR signaling - WP3875 (Homo sapiens)
- Acetylcholine synthesis - WP528 (Homo sapiens)
- Adverse outcome pathway for mitochondrial complex 1 (C1) inhibition - WP4914 (Homo sapiens)
- Aerobic glycolysis - WP4629 (Homo sapiens)
- Aerobic glycolysis - augmented - WP4628 (Homo sapiens)
- Aflatoxin B1 metabolism - WP699 (Homo sapiens)
- Alanine and aspartate metabolism - WP106 (Homo sapiens)
- Allograft rejection - WP2328 (Homo sapiens)
- Alpha 6 beta 4 signaling - WP244 (Homo sapiens)
- Alternative pathway of fetal androgen synthesis - WP4524 (Homo sapiens)
- Amino acid metabolism - WP3925 (Homo sapiens)
- Amino acid transport defects (IEMs) - WP5029 (Homo sapiens)
- Androgen receptor signaling - WP138 (Homo sapiens)
- Angiogenesis - WP1539 (Homo sapiens)
- Angiopoietin-like protein 8 regulatory pathway - WP3915 (Homo sapiens)
- Angiotensin II receptor type 1 pathway - WP5036 (Homo sapiens)
- Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway - WP5113 (Homo sapiens)
- ApoE and miR-146 in inflammation and atherosclerosis - WP3926 (Homo sapiens)
- Apoptosis - WP254 (Homo sapiens)
- Apoptosis modulation and signaling - WP1772 (Homo sapiens)
- Apoptosis modulation by HSP70 - WP384 (Homo sapiens)
- Arachidonate epoxygenase / epoxide hydrolase - WP678 (Homo sapiens)
- Arachidonic acid (AA, ARA) oxylipin metabolism - WP5155 (Homo sapiens)
- Arsenic metabolism and reactive oxygen species generation - WP5233 (Homo sapiens)
- Aryl hydrocarbon receptor pathway - WP2586 (Homo sapiens)
- Aryl hydrocarbon receptor pathway - WP2873 (Homo sapiens)
- Aspirin and miRNAs - WP4707 (Homo sapiens)
- Autophagy - WP4923 (Homo sapiens)
- Axon guidance - WP5289 (Homo sapiens)
- BDNF-TrkB signaling - WP3676 (Homo sapiens)
- Bardet-Biedl syndrome - WP5234 (Homo sapiens)
- Base excision repair - WP4752 (Homo sapiens)
- Bile acid synthesis and enterohepatic circulation - WP4389 (Homo sapiens)
- Biochemical pathways: part I - WP3604 (Homo sapiens)
- Biogenic amine synthesis - WP550 (Homo sapiens)
- Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine - WP4156 (Homo sapiens)
- Biotin metabolism, including IMDs - WP5031 (Homo sapiens)
- Bone morphogenic protein signaling and regulation - WP1425 (Homo sapiens)
- Brain-derived neurotrophic factor (BDNF) signaling - WP2380 (Homo sapiens)
- Butyrate-induced histone acetylation - WP2366 (Homo sapiens)
- CAMKK2 pathway - WP4874 (Homo sapiens)
- Cannabinoid receptor signaling - WP3869 (Homo sapiens)
- Canonical NF-kB pathway - WP4562 (Homo sapiens)
- Canonical and non-canonical Notch signaling - WP3845 (Homo sapiens)
- Canonical and non-canonical TGF-B signaling - WP3874 (Homo sapiens)
- Carnosine metabolism of glial cells - WP5313 (Homo sapiens)
- Cell cycle - WP179 (Homo sapiens)
- Cell differentiation - expanded index - WP2023 (Homo sapiens)
- Cell differentiation - index - WP2029 (Homo sapiens)
- Cell lineage map for neuronal differentiation - WP5417 (Homo sapiens)
- Cells and molecules involved in local acute inflammatory response - WP4493 (Homo sapiens)
- Cellular proteostasis - WP4918 (Homo sapiens)
- Cerebral organic acidurias, including diseases - WP4519 (Homo sapiens)
- Chemokine signaling - WP3929 (Homo sapiens)
- Cholestasis - WP5238 (Homo sapiens)
- Cholesterol biosynthesis pathway - WP197 (Homo sapiens)
- Cholesterol biosynthesis pathway in hepatocytes - WP5329 (Homo sapiens)
- Cholesterol metabolism - WP5304 (Homo sapiens)
- Cholesterol metabolism with Bloch and Kandutsch-Russell pathways - WP4718 (Homo sapiens)
- Cholesterol synthesis disorders - WP5193 (Homo sapiens)
- Chronic hyperglycemia impairment of neuron function - WP5283 (Homo sapiens)
- Ciliary landscape - WP4352 (Homo sapiens)
- Ciliopathies - WP4803 (Homo sapiens)
- Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolism - WP4523 (Homo sapiens)
- Clear cell renal cell carcinoma pathways - WP4018 (Homo sapiens)
- Cohesin complex - Cornelia de Lange syndrome - WP5117 (Homo sapiens)
- Complement activation - WP545 (Homo sapiens)
- Complement system in neuronal development and plasticity - WP5090 (Homo sapiens)
- Constitutive androstane receptor pathway - WP2875 (Homo sapiens)
- Conversion of angiotensinogen to angiotensin II - WP4818 (Homo sapiens)
- Corticotropin-releasing hormone signaling - WP2355 (Homo sapiens)
- Creatine pathway - WP5190 (Homo sapiens)
- Cysteine and methionine catabolism - WP4504 (Homo sapiens)
- Cytokine-cytokine receptor interaction - WP5473 (Homo sapiens)
- Cytokines and inflammatory response - WP530 (Homo sapiens)
- Cytoplasmic ribosomal proteins - WP477 (Homo sapiens)
- Cytosine methylation - WP3585 (Homo sapiens)
- DNA adduct formation leading to kidney failure - WP5389 (Homo sapiens)
- DNA damage response - WP707 (Homo sapiens)
- DNA mismatch repair - WP531 (Homo sapiens)
- DNA repair pathways, full network - WP4946 (Homo sapiens)
- DNA replication - WP466 (Homo sapiens)
- DYRK1A involvement regarding cell proliferation in brain development - WP5180 (Homo sapiens)
- Degradation pathway of sphingolipids, including diseases - WP4153 (Homo sapiens)
- Development of ureteric derived collecting system - WP5053 (Homo sapiens)
- Diclofenac metabolic pathway - WP2491 (Homo sapiens)
- Diet-dependent trimethylamine/trimethylamine N-oxide metabolism - WP5219 (Homo sapiens)
- Direct reversal repair - WP4931 (Homo sapiens)
- Disorders in ketone body synthesis - WP5175 (Homo sapiens)
- Disorders of bile acid synthesis and biliary transport - WP5176 (Homo sapiens)
- Disorders of folate metabolism and transport - WP4259 (Homo sapiens)
- Disorders of fructose metabolism - WP5178 (Homo sapiens)
- Disorders of galactose metabolism - WP5173 (Homo sapiens)
- Disruption of postsynaptic signaling by CNV - WP4875 (Homo sapiens)
- Docosahexaenoic acid oxylipin metabolism - WP5154 (Homo sapiens)
- Dopamine metabolism - WP2436 (Homo sapiens)
- Dopaminergic neurogenesis - WP2855 (Homo sapiens)
- Downregulation of ACE2 by SARS-CoV-2 spike protein - WP4799 (Homo sapiens)
- Dravet syndrome - WP5200 (Homo sapiens)
- Drug induction of bile acid pathway - WP2289 (Homo sapiens)
- EGF/EGFR signaling - WP437 (Homo sapiens)
- EGFR tyrosine kinase inhibitor resistance - WP4806 (Homo sapiens)
- EPO receptor signaling - WP581 (Homo sapiens)
- Ebstein-Barr virus LMP1 signaling - WP262 (Homo sapiens)
- Ectoderm differentiation - WP2858 (Homo sapiens)
- Eicosanoid metabolism via cyclooxygenases (COX) - WP4719 (Homo sapiens)
- Eicosanoid metabolism via cytochrome P450 monooxygenases pathway - WP4720 (Homo sapiens)
- Eicosanoid metabolism via lipooxygenases (LOX) - WP4721 (Homo sapiens)
- Eicosanoid synthesis - WP167 (Homo sapiens)
- Electron transport chain: OXPHOS system in mitochondria - WP111 (Homo sapiens)
- Embryonic stem cell pluripotency pathways - WP3931 (Homo sapiens)
- Endothelin pathways - WP2197 (Homo sapiens)
- Energy metabolism - WP1541 (Homo sapiens)
- Enterocyte cholesterol metabolism - WP5333 (Homo sapiens)
- Enterohepatic circulation of bile acids - WP5396 (Homo sapiens)
- ErbB signaling - WP673 (Homo sapiens)
- Estrogen metabolism - WP5276 (Homo sapiens)
- Estrogen metabolism - WP697 (Homo sapiens)
- Estrogen receptor pathway - WP2881 (Homo sapiens)
- Estrogen signaling - WP712 (Homo sapiens)
- Ethanol effects on histone modifications - WP3996 (Homo sapiens)
- Ethanol metabolism production of ROS by CYP2E1 - WP4269 (Homo sapiens)
- Ether lipid biosynthesis - WP5275 (Homo sapiens)
- Ethylmalonic encephalopathy - WP5030 (Homo sapiens)
- Eukaryotic transcription initiation - WP405 (Homo sapiens)
- Extracellular vesicle-mediated signaling in recipient cells - WP2870 (Homo sapiens)
- FGF23 signaling in hypophosphatemic rickets and related disorders - WP4790 (Homo sapiens)
- FOXA2 pathway - WP5066 (Homo sapiens)
- Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling - WP3850 (Homo sapiens)
- Farnesoid X receptor pathway - WP2879 (Homo sapiens)
- Farnesyl to CoQ10 metabolism - WP5274 (Homo sapiens)
- Fas ligand pathway and stress induction of heat shock proteins - WP314 (Homo sapiens)
- Fatty acid and lipoprotein transport in hepatocytes - WP5323 (Homo sapiens)
- Fatty acid beta-oxidation - WP143 (Homo sapiens)
- Fatty acid biosynthesis - WP357 (Homo sapiens)
- Fatty acid omega-oxidation - WP206 (Homo sapiens)
- Fatty acid transporters - WP5061 (Homo sapiens)
- Focal adhesion - WP306 (Homo sapiens)
- Focal adhesion: PI3K-Akt-mTOR-signaling - WP3932 (Homo sapiens)
- Folate metabolism - WP176 (Homo sapiens)
- Fragile X syndrome - WP4549 (Homo sapiens)
- G protein signaling - WP35 (Homo sapiens)
- G1 to S cell cycle control - WP45 (Homo sapiens)
- G13 signaling - WP524 (Homo sapiens)
- GABA metabolism (aka GHB) - WP4157 (Homo sapiens)
- GABA receptor signaling - WP4159 (Homo sapiens)
- GDNF signaling - WP5143 (Homo sapiens)
- GDNF/RET signaling axis - WP4830 (Homo sapiens)
- GPCRs, class B secretin-like - WP334 (Homo sapiens)
- GPCRs, other - WP117 (Homo sapiens)
- Galanin receptor pathway - WP4970 (Homo sapiens)
- Gamma-glutamyl cycle for the biosynthesis and degradation of glutathione, including diseases - WP4518 (Homo sapiens)
- Gene regulatory network modeling somitogenesis - WP2854 (Homo sapiens)
- Glial cell differentiation - WP2276 (Homo sapiens)
- Glucose homeostasis - WP661 (Homo sapiens)
- Glucuronidation - WP698 (Homo sapiens)
- Glutathione metabolism - WP100 (Homo sapiens)
- Glycine metabolism - WP1495 (Homo sapiens)
- Glycogen synthesis and degradation - WP500 (Homo sapiens)
- Glycolysis and gluconeogenesis - WP534 (Homo sapiens)
- Glycolysis in senescence - WP5049 (Homo sapiens)
- Glycosaminoglycan degradation - WP4815 (Homo sapiens)
- Glycosphingolipid metabolism - WP5292 (Homo sapiens)
- Glyoxylate metabolism - WP5166 (Homo sapiens)
- HDAC6 interactions in the central nervous system - WP5426 (Homo sapiens)
- HIF1A and PPARG in hypertrophic cardiomyopathy - WP2456 (Homo sapiens)
- HIPK2 in kidney fibrosis - WP4751 (Homo sapiens)
- Hedgehog signaling - WP4249 (Homo sapiens)
- Hedgehog signaling - WP47 (Homo sapiens)
- Hereditary leiomyomatosis and renal cell carcinoma pathway - WP4206 (Homo sapiens)
- Hfe effect on hepcidin production - WP3924 (Homo sapiens)
- Hippocampal synaptogenesis and neurogenesis - WP5231 (Homo sapiens)
- Histone modifications - WP2369 (Homo sapiens)
- ID signaling - WP53 (Homo sapiens)
- IL1 signaling - WP195 (Homo sapiens)
- IL10 anti-inflammatory signaling - WP4495 (Homo sapiens)
- IL17 signaling - WP2112 (Homo sapiens)
- IL2 signaling - WP49 (Homo sapiens)
- IL4 signaling - WP395 (Homo sapiens)
- IL5 signaling - WP127 (Homo sapiens)
- IL6 signaling - WP364 (Homo sapiens)
- Inflammatory response pathway - WP453 (Homo sapiens)
- Insulin signaling - WP481 (Homo sapiens)
- Insulin signaling in adipocytes (diabetic condition) - WP3635 (Homo sapiens)
- Integrin-mediated cell adhesion - WP185 (Homo sapiens)
- Interactions between LOXL4 and oxidative stress pathway - WP3670 (Homo sapiens)
- Interleukin-1 (IL-1) structural pathway - WP2637 (Homo sapiens)
- Interleukin-1 induced activation of NF-kB - WP3656 (Homo sapiens)
- Iron metabolism disorders - WP5172 (Homo sapiens)
- Joubert syndrome - WP4656 (Homo sapiens)
- Ketogenesis and ketolysis - WP4742 (Homo sapiens)
- Kleefstra syndrome - WP5351 (Homo sapiens)
- Krebs cycle disorders - WP4236 (Homo sapiens)
- Kynurenine pathway and links to cell senescence - WP5044 (Homo sapiens)
- Lactate shuttle in glial cells - WP5314 (Homo sapiens)
- Leptin and adiponectin - WP3934 (Homo sapiens)
- Leukotriene metabolic pathway - WP5171 (Homo sapiens)
- Lidocaine metabolism - WP2646 (Homo sapiens)
- Lipid metabolism pathway - WP3965 (Homo sapiens)
- Lipid particles composition - WP3601 (Homo sapiens)
- Liver X receptor pathway - WP2874 (Homo sapiens)
- Liver steatosis adverse outcome pathway - WP4010 (Homo sapiens)
- MAPK cascade - WP422 (Homo sapiens)
- MAPK signaling - WP382 (Homo sapiens)
- MECP2 and associated Rett syndrome - WP3584 (Homo sapiens)
- MET in type 1 papillary renal cell carcinoma - WP4205 (Homo sapiens)
- MTHFR deficiency - WP4288 (Homo sapiens)
- Major receptors targeted by epinephrine and norepinephrine - WP4589 (Homo sapiens)
- Malate-aspartate shuttle - WP4315 (Homo sapiens)
- Markers of kidney cell lineage - WP5236 (Homo sapiens)
- Metabolic pathway of LDL, HDL and TG, including diseases - WP4522 (Homo sapiens)
- Metabolism of alpha-linolenic acid - WP4586 (Homo sapiens)
- Metabolism of dichloroethylene by CYP450 - WP3666 (Homo sapiens)
- Metabolism overview - WP3602 (Homo sapiens)
- Mevalonate arm of cholesterol biosynthesis pathway - WP4190 (Homo sapiens)
- Mevalonate arm of cholesterol biosynthesis pathway with inhibitors - WP4189 (Homo sapiens)
- Mevalonate pathway - WP3963 (Homo sapiens)
- Microtubule cytoskeleton regulation - WP2038 (Homo sapiens)
- Mineralocorticoid biosynthesis - WP5279 (Homo sapiens)
- Mitochondrial beta-oxidation - WP5241 (Homo sapiens)
- Mitochondrial complex I assembly model OXPHOS system - WP4324 (Homo sapiens)
- Mitochondrial complex I inhibition leading to chemical-induced Fanconi syndrome - WP4944 (Homo sapiens)
- Mitochondrial complex I inhibition leading to parkinsonian motor deficits - WP4945 (Homo sapiens)
- Mitochondrial complex II assembly - WP4920 (Homo sapiens)
- Mitochondrial complex III assembly - WP4921 (Homo sapiens)
- Mitochondrial complex IV assembly - WP4922 (Homo sapiens)
- Mitochondrial complex inhibition leading to liver injury - WP5034 (Homo sapiens)
- Mitochondrial fatty acid oxidation disorders - WP5123 (Homo sapiens)
- Mitochondrial fatty acid synthesis pathway - WP4317 (Homo sapiens)
- Mitochondrial fission and fusion - WP4318 (Homo sapiens)
- Mitochondrial gene expression - WP391 (Homo sapiens)
- Mitochondrial immune response to SARS-CoV-2 - WP5038 (Homo sapiens)
- Mitochondrial long chain fatty acid beta-oxidation - WP368 (Homo sapiens)
- Modulation of PI3K-Akt-mTOR signaling by bioactive sphingolipids - WP5192 (Homo sapiens)
- Monoamine GPCRs - WP58 (Homo sapiens)
- Monoamine transport - WP727 (Homo sapiens)
- NAD+ biosynthetic pathways - WP3645 (Homo sapiens)
- NAD+ metabolism - WP3644 (Homo sapiens)
- NF1 copy number variation syndrome - WP5366 (Homo sapiens)
- NIPBL role in DNA damage - Cornelia de Lange syndrome - WP5119 (Homo sapiens)
- NPHP1 deletion syndrome - WP5399 (Homo sapiens)
- NRF2 pathway - WP2884 (Homo sapiens)
- NRF2-ARE regulation - WP4357 (Homo sapiens)
- NRXN1 deletion syndrome - WP5398 (Homo sapiens)
- Nephrogenesis - WP5052 (Homo sapiens)
- Nephrotic syndrome - WP4758 (Homo sapiens)
- Nephrotoxcicity adverse outcome pathway - WP5229 (Homo sapiens)
- Neural crest cell migration during development - WP4564 (Homo sapiens)
- Neural crest differentiation - WP2064 (Homo sapiens)
- Neuroinflammation - WP4919 (Homo sapiens)
- Neuroinflammation and glutamatergic signaling - WP5083 (Homo sapiens)
- Neurotransmitter disorders - WP4220 (Homo sapiens)
- Nicotine effect on dopaminergic neurons - WP1602 (Homo sapiens)
- Nod-like receptor (NLR) signaling - WP288 (Homo sapiens)
- Non-classical role of vitamin D - WP5133 (Homo sapiens)
- Nonalcoholic fatty liver disease - WP4396 (Homo sapiens)
- Notch signaling - WP268 (Homo sapiens)
- Notch signaling - WP61 (Homo sapiens)
- Nuclear receptors - WP170 (Homo sapiens)
- Nuclear receptors in lipid metabolism and toxicity - WP299 (Homo sapiens)
- Nuclear receptors meta-pathway - WP2882 (Homo sapiens)
- Octadecanoid formation from linoleic acid - WP5324 (Homo sapiens)
- Oligodendrocyte specification and differentiation, leading to myelin components for CNS - WP4304 (Homo sapiens)
- Omega-3 / omega-6 fatty acid synthesis - WP4723 (Homo sapiens)
- Omega-9 fatty acid synthesis - WP4724 (Homo sapiens)
- Opioid receptor pathways - WP5093 (Homo sapiens)
- Oxidation by cytochrome P450 - WP43 (Homo sapiens)
- Oxidative damage response - WP3941 (Homo sapiens)
- Oxidative phosphorylation - WP623 (Homo sapiens)
- Oxidative stress response - WP408 (Homo sapiens)
- Oxysterols derived from cholesterol - WP4545 (Homo sapiens)
- Oxytocin signaling - WP2889 (Homo sapiens)
- PAFAH1B1 copy number variation - WP5409 (Homo sapiens)
- PCSK9-mediated LDL receptor degradation - WP2846 (Homo sapiens)
- PDGF pathway - WP2526 (Homo sapiens)
- PGK1, PKM2, KHKC/KHKA acting as protein kinases - WP5433 (Homo sapiens)
- PI3K-Akt signaling - WP4172 (Homo sapiens)
- PI3K/AKT/mTOR - vitamin D3 signaling - WP4141 (Homo sapiens)
- PPAR signaling - WP3942 (Homo sapiens)
- PPAR-alpha pathway - WP2878 (Homo sapiens)
- Pentose phosphate metabolism - WP134 (Homo sapiens)
- Pentose phosphate pathway in senescent cells - WP5043 (Homo sapiens)
- Phase I biotransformations, non-P450 - WP136 (Homo sapiens)
- Phosphodiesterases in neuronal function - WP4222 (Homo sapiens)
- Phosphoinositide 3-kinase (PI3K) family - WP5472 (Homo sapiens)
- Phosphoinositides metabolism - WP4971 (Homo sapiens)
- Pluripotent stem cell differentiation pathway - WP2848 (Homo sapiens)
- Polycystic kidney disease pathway - WP2571 (Homo sapiens)
- Polyol pathway - WP690 (Homo sapiens)
- Prader-Willi and Angelman syndrome - WP3998 (Homo sapiens)
- Pregnane X receptor pathway - WP2876 (Homo sapiens)
- Primary focal segmental glomerulosclerosis (FSGS) - WP2572 (Homo sapiens)
- Prostaglandin and leukotriene metabolism in senescence - WP5122 (Homo sapiens)
- Prostaglandin and leukotriene metabolism in senescence - WP5321 (Homo sapiens)
- Prostaglandin signaling - WP5088 (Homo sapiens)
- Prostaglandin synthesis and regulation - WP98 (Homo sapiens)
- Proximal tubule transport - WP4917 (Homo sapiens)
- Ras signaling - WP4223 (Homo sapiens)
- Regucalcin in proximal tubule epithelial kidney cells - WP4838 (Homo sapiens)
- Regulation of Wnt / B-catenin signaling by small molecule compounds - WP3664 (Homo sapiens)
- Regulation of actin cytoskeleton - WP51 (Homo sapiens)
- Relationship between inflammation, COX-2 and EGFR - WP4483 (Homo sapiens)
- Renin-angiotensin-aldosterone system (RAAS) - WP4756 (Homo sapiens)
- Retinol metabolism - WP5188 (Homo sapiens)
- Rett syndrome - WP4312 (Homo sapiens)
- SREBF and miR33 in cholesterol and lipid homeostasis - WP2011 (Homo sapiens)
- Selenium metabolism and selenoproteins - WP28 (Homo sapiens)
- Senescence-associated secretory phenotype (SASP) - WP3391 (Homo sapiens)
- Serine metabolism - WP4688 (Homo sapiens)
- Serotonin and anxiety - WP3947 (Homo sapiens)
- Serotonin receptor 2 and ELK-SRF/GATA4 signaling - WP732 (Homo sapiens)
- Serotonin transporter activity - WP1455 (Homo sapiens)
- Sialylation - WP5151 (Homo sapiens)
- Signal transduction through IL1R - WP4496 (Homo sapiens)
- Small ligand GPCRs - WP247 (Homo sapiens)
- Smith-Magenis and Potocki-Lupski syndrome copy number variation - WP5381 (Homo sapiens)
- Sphingolipid pathway - WP1422 (Homo sapiens)
- Spina bifida - WP5150 (Homo sapiens)
- Statin inhibition of cholesterol production - WP430 (Homo sapiens)
- Steroid biosynthesis - WP496 (Homo sapiens)
- Sterol regulatory element-binding proteins (SREBP) signaling - WP1982 (Homo sapiens)
- Synaptic signaling associated with autism spectrum disorder - WP4539 (Homo sapiens)
- Synaptic vesicle pathway - WP2267 (Homo sapiens)
- TCA cycle (aka Krebs or citric acid cycle) - WP78 (Homo sapiens)
- TCA cycle and deficiency of pyruvate dehydrogenase complex (PDHc) - WP2453 (Homo sapiens)
- TCA cycle in senescence - WP5050 (Homo sapiens)
- TGF-beta receptor signaling - WP560 (Homo sapiens)
- TGF-beta receptor signaling in skeletal dysplasias - WP4816 (Homo sapiens)
- TGF-beta signaling pathway - WP366 (Homo sapiens)
- TGFB / Smad signaling - WP5382 (Homo sapiens)
- TNF-alpha signaling - WP231 (Homo sapiens)
- TNF-related weak inducer of apoptosis (TWEAK) signaling - WP2036 (Homo sapiens)
- TP53 network - WP1742 (Homo sapiens)
- Tamoxifen metabolism - WP691 (Homo sapiens)
- Target of rapamycin signaling - WP1471 (Homo sapiens)
- Tgif disruption of Shh signaling - WP3674 (Homo sapiens)
- Thyroid hormone imbalance leading to neurodevelopmental abnormalities - WP5227 (Homo sapiens)
- Thyroid hormones production and peripheral downstream signaling effects - WP4746 (Homo sapiens)
- Thyroid stimulating hormone (TSH) signaling - WP2032 (Homo sapiens)
- Toll-like receptor signaling - WP75 (Homo sapiens)
- Transcription factor regulation in adipogenesis - WP3599 (Homo sapiens)
- Transcriptional activation by NRF2 in response to phytochemicals - WP3 (Homo sapiens)
- Transcriptional cascade regulating adipogenesis - WP4211 (Homo sapiens)
- Triacylglyceride synthesis - WP325 (Homo sapiens)
- Type 2 papillary renal cell carcinoma - WP4241 (Homo sapiens)
- Urea cycle and associated pathways - WP4595 (Homo sapiens)
- Urea cycle and metabolism of amino groups - WP497 (Homo sapiens)
- Urea cycle and related diseases - WP4571 (Homo sapiens)
- Urotensin-II-mediated signaling - WP5158 (Homo sapiens)
- VEGFA-VEGFR2 signaling - WP3888 (Homo sapiens)
- Valproic acid pathway - WP3871 (Homo sapiens)
- Vasopressin-regulated water reabsorption - WP5085 (Homo sapiens)
- Vitamin A and carotenoid metabolism - WP716 (Homo sapiens)
- Vitamin B12 disorders - WP4271 (Homo sapiens)
- Vitamin B12 metabolism - WP1533 (Homo sapiens)
- Vitamin D in inflammatory diseases - WP4482 (Homo sapiens)
- Vitamin D metabolism - WP1531 (Homo sapiens)
- Vitamin D receptor pathway - WP2877 (Homo sapiens)
- Vitamin D-sensitive calcium signaling in depression - WP4698 (Homo sapiens)
- Vitamins A and D - action mechanisms - WP4342 (Homo sapiens)
- Warburg effect modulated by deubiquitinating enzymes and their substrates - WP5216 (Homo sapiens)
- Wnt signaling - WP363 (Homo sapiens)
- Wnt signaling - WP428 (Homo sapiens)
- Wnt signaling and pluripotency - WP399 (Homo sapiens)
- Wnt signaling in kidney disease - WP4150 (Homo sapiens)
- Wnt/Beta-catenin signaling inhibitors in current and past clinical trials - WP5442 (Homo sapiens)
- Zinc homeostasis - WP3529 (Homo sapiens)
- mBDNF and proBDNF regulation of GABA neurotransmission - WP4829 (Homo sapiens)
- mRNA, protein, and metabolite inducation pathway by cyclosporin A - WP3953 (Homo sapiens)
- miRNA biogenesis - WP2338 (Homo sapiens)
- miRNA role in immune response in sepsis - WP4329 (Homo sapiens)
- p38 MAPK signaling - WP400 (Homo sapiens)
- p53 transcriptional gene network - WP4963 (Homo sapiens)
How to Contribute
The list of pathways is not static and can be updated at any time. If you know of a pathway that should be added, please contact one of the administrators, Luiz Ladeira (lcladeira[AT]uliege.be) or Bernard Staumont (b.staumont[AT]uliege.be).
Support
This work was performed in the context of the ONTOX project that has received funding from the European Union’s Horizon 2020 Research and Innovation programme under grant agreement No 963845. ONTOX is part of the ASPIS project cluster.
Community Members
Authors of Community Pathways
Luiz C. M. Ladeira , Julivana , Friederike Ehrhart , Egon Willighagen , Alex Pico , Eric Weitz , Pierre Klemmer , Esther Umwamikazi , Aishwarya Iyer , Kristina Hanspers , Ninagerrekens , Javier Millán Acosta , JulietaCosta , Kieran Reidy , ElenaDR , Jolijn Hekma Wierda , Kay Veurink , Clarissa Falempin , Marvin Martens , Denise Slenter , Victor Avramov , Lauren J. Dupuis , Magda M. Latorre , Daria Shumkova , AAR&Co , Andika Tan , Anders Riutta , Ewoud , Conroy lipids , Lars Willighagen , Rens Eikelboom , Caroline F. Thorn , Jinwook.seo , Thomas Kelder , Martijn Van Iersel , Christine Chichester , Nuno , Martina Summer-Kutmon , Finterly Hu , Alexmadsen1 , NetPath , Lucien Cayer , Susan Coort , Andra Waagmeester , Frances , Adrien Defay , Jean Gonzales , Zahra Roudbari , Marianthi Kalafati , Arturo Manzo-Fontes P D , Andrew Kwa , Hubert Hug , Anwesha Bohler , Anna Baya Meuleman , Chris Evelo , Kelly Janssen , Pieter Giesbertz , Lynn M. Ferrante , Michiel Adriaens , Daniela Digles , Nathan Salomonis , Deborah Micael , Akhilesh Pandey , Eline Sanders , Irene Hemel , Robertbaertsch , Theodore T. Batalis , Laur S , James Bjork , Amnah Siddiqa , Elisa Cirillo , Stefan Raats , Rocheliene , Nhung Pham , Alexander C. Zambon , Angelika , Beth Lawlor , Marc Gillespie , Jildau Bouwman , Josip , Anam , Felix Rckert , Ryan Miller , Daniel Domingo-Fdez , Ismael Reyes , Paolo Romano , Lora Simons , John W. Newman , Zuzanna Lech , Prakamya Gupta , Rianne Fijten , Aminkhazeeitabari , Susan M. Bachmann , Viole H , Dr Luis Alberto Lightbourn P D , , Josien Landman , Vfunari , Babiker Malik Osman , Dr. T. S. Keshava Prasad , Rex D A B , Jasmijn van Zaanen , Laetitia Flammang , Isabel Wassink , Iliana Campillo Sach , Bruce Conklin , Sergey Dmitriev , Badrul Yahaya , Jonathan Mélius , Samuel Sklar , Jeroen Pennings , Laurent Winckers , Britt Pieters , Eveline Schoenmaker , Velina Pencheva , Michael Lieberman , Patrick Ahles , Ned Mantei , Bart Smeets , Daniel Riggins , Tom Pauly , Eveline Peterse , Ritchie Lee , Ingebude , Alp Irkilmez , Lisa Koole , Lara Vreeswijk , Tim Zotti , Sebastien Burel , Ferry Jagers , Jack007 , Kdahlquist , Jonas Hummel , Stan Gaj , Vanessa Sousa , Xin Ding , Ernesto Diaz-Flores , David Koren , Veerle Horsting , Ado , Nina Valenbreder , Sam Drabbe , Amaury Pelzer , Maria van de Meent , Jesse Vercoulen , Enzo Chiaradia , Alexandra Bosch , Marek Ostaszewski , Amber Koning , Miriam Babukhian , Lea Doerner , Pepin Marshall , Roelod , Carlos J Pirola , Sabine Daemen , Mireille Sthijns , Madeline Kosho , Luigi Maiorana , Eric Jaehnig , Lina Schiffer , William J Griffiths , Laura Van Zon , Chun Chen , Robert C. Murphy , Andreas Zankl , Chesley De Windt , JT. Saito , Priyanka K , Licong , Jeroen Kearns , Danielle Truong , Egoyenechea , Jill Dunham , Damariz Rivero , Youssef Walid , Megi Kass , Elisson nl , Charles Redfern , Mark Scott , Anita Chow , Kushidat , Yasmin Omar , Lobke Meels , Essam Sharaf , Harm Nijveen , Nick Fidelman , The Herald , Mirk Baranzini , Mark A. Hershberger , Ambar21 , Wayan Monet , Emilia Agasi , Nasim Bahram Sangani , M Aguirre , Agustin Gonzalez-Vicente , Celine Malyar , Linda Rieswijk , Axel Weber , Joppe014 , Shamith Samarajiwa , Joops05 , Noopur Sinha , Mary-Elizabeth Patti , Federica Eduati , Congcong Yin , Anna De Brouwer , Raquel Grosman , Richard Delava , Sonia Balan , Nikita Krstevska , Celestecurreri , Cléophée Bruchou , Ellaverheggen , Peter Swanenberg , JJv Heijden , MysticArchers , Bingo , Chris Gillissen , Amadeo , Jacob Windsor , Claire Lemmens , Carlos Borroto , Dan Fornika , Gabriel Couillaud , Claire Billingsley , Kingson ''junsheng Thang'' Luc , Niradiz Reyes , Jesper , Anna Van Wersch , Joanna S. Fong , Bzhang , Dex Duncan , Julia Johnsson , Ann Friesacher , Boghog , Madhu Rohini , Cizar , Kufer , Neerincx a , Allan Kuchinsky , Humera Fiaz , Ellen Tuninsky , Arik , Mohhafez , Zhangx888 , KHALID RASHID , Xuyongdeng , Harald Schmidt , Robert Andrews , Mikhail Monakhov , Kristina Hettne , Marcell Levay , Rick Hendriks , Rollie , Cenna Doornbos , Elisa Santarsiero , Doreen Jost , Mario Zubak , Tade Idowu , Denise Kalbe , Fruzsina Magyar , Aysegul Celik , Nadia Simone Jonckheere , Aria Jadhav , Vinny Lynch , Pip van Lier , Melodyner , Diana Garcia , Ozan Ozisik , Rvanrosmeulen , Max Van Son , 137.120.89.28 , Strand Life Sciences Pvt. Ltd , ReactomeTeam , Amy Kutmon , Ruke Achoja , Vand Conte , Lars Eijssen , XNauts , Anatolymikutin , Dan Bolser , Ray Andrews II , Miranda Stobbe , Sander Houten , Nurit Gal , Andrea Arias Sáez , Diana Brancadoro , Burak , Glenda Nicioli Da Silva , Jlw9 , Rik Lahaije , Dr. Renu Goel , Johannes W. Dietrich , Judith M. Boer , Zezhong Li , Ingrid Felicidade , Dr.P.R.Sudhakaran , Mzolisi Mtshaulana , Asios Olia , Lucia Ribeiro , Mingye Wang , Kim de Nooijer , Alvin Kho , Leonie Van De Ven , Marlen m , Sharona Elgavish , Ericwexler , Giovanna Valenti , Trovato Angela , and Ramesh .