Disease Pathways at WikiPathways
The Disease Community highlights pathways related to human disease, and is designed as a central organizing point for exploring, curating and expanding the collection of disease pathways.
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Community Pathways
Table FiltersThis community helps to curate 93 pathways:
- 10q11.21q11.23 copy number variation syndrome - WP5352 (Homo sapiens)
- 11p11.2 copy number variation syndrome - WP5348 (Homo sapiens)
- 16p11.2 proximal deletion syndrome - WP4949 (Homo sapiens)
- 17q12 copy number variation syndrome - WP5287 (Homo sapiens)
- 1p36 copy number variation syndrome - WP5345 (Homo sapiens)
- 8p23.1 copy number variation syndrome - WP5346 (Homo sapiens)
- Abnormal calcium handling and its effects on muscle contraction in DMD - WP5343 (Homo sapiens)
- Acute viral myocarditis - WP4298 (Homo sapiens)
- Affected pathways in Duchenne muscular dystrophy - WP5356 (Homo sapiens)
- Alzheimer's disease and miRNA effects - WP2059 (Homo sapiens)
- Amino acid transport defects (IEMs) - WP5029 (Homo sapiens)
- Androgen receptor network in prostate cancer - WP2263 (Homo sapiens)
- ApoE and miR-146 in inflammation and atherosclerosis - WP3926 (Homo sapiens)
- Autophagy in pancreatic ductal adenocarcinoma - WP5331 (Homo sapiens)
- Bladder cancer - WP2828 (Homo sapiens)
- Breast cancer pathway - WP4262 (Homo sapiens)
- Cannabinoid receptor signaling - WP3869 (Homo sapiens)
- Clear cell renal cell carcinoma pathways - WP4018 (Homo sapiens)
- Common pathways underlying drug addiction - WP2636 (Homo sapiens)
- Dengue-2 interactions with complement and coagulation cascades - WP3896 (Homo sapiens)
- Deregulation of Rab and Rab effector genes in bladder cancer - WP2291 (Homo sapiens)
- Disorders of folate metabolism and transport - WP4259 (Homo sapiens)
- Dual hijack model of Vif in HIV infection - WP3300 (Homo sapiens)
- ERK pathway in Huntington's disease - WP3853 (Homo sapiens)
- Ebola virus infection in host - WP4217 (Homo sapiens)
- Effect of progerin on genes involved in progeria - WP4320 (Homo sapiens)
- Endometrial cancer - WP4155 (Homo sapiens)
- Estradiol regulation in porto-sinusoidal vascular disease - WP5235 (Homo sapiens)
- Evolocumab mechanism to reduce LDL cholesterol - WP3408 (Homo sapiens)
- FBXL10 enhancement of MAP/ERK signaling in diffuse large B-cell lymphoma - WP4553 (Homo sapiens)
- FTO obesity variant mechanism - WP3407 (Homo sapiens)
- Fluoropyrimidine activity - WP1601 (Homo sapiens)
- Folate-alcohol and cancer pathway hypotheses - WP1589 (Homo sapiens)
- HIPK2 in kidney fibrosis - WP4751 (Homo sapiens)
- Head and neck squamous cell carcinoma - WP4674 (Homo sapiens)
- Hepatitis B infection - WP4666 (Homo sapiens)
- Hepatitis C and hepatocellular carcinoma - WP3646 (Homo sapiens)
- Hereditary leiomyomatosis and renal cell carcinoma pathway - WP4206 (Homo sapiens)
- Hippo signaling regulation - WP4540 (Homo sapiens)
- Hippo-Merlin signaling dysregulation - WP4541 (Homo sapiens)
- Hypertrophy model - WP516 (Homo sapiens)
- Hypothesized pathways in pathogenesis of cardiovascular disease - WP3668 (Homo sapiens)
- IL1 and megakaryocytes in obesity - WP2865 (Homo sapiens)
- Immune infiltration in pancreatic cancer - WP5285 (Homo sapiens)
- Influenza A virus infection - WP1438 (Homo sapiens)
- Integrated cancer pathway - WP1971 (Homo sapiens)
- Intracellular trafficking proteins involved in CMT neuropathy - WP4856 (Homo sapiens)
- Kleefstra syndrome - WP5351 (Homo sapiens)
- Krebs cycle disorders - WP4236 (Homo sapiens)
- Lung fibrosis - WP3624 (Homo sapiens)
- MECP2 and associated Rett syndrome - WP3584 (Homo sapiens)
- MET in type 1 papillary renal cell carcinoma - WP4205 (Homo sapiens)
- MTHFR deficiency - WP4288 (Homo sapiens)
- Melanoma - WP4685 (Homo sapiens)
- Metabolic pathway of LDL, HDL and TG, including diseases - WP4522 (Homo sapiens)
- Metabolic reprogramming in colon cancer - WP4290 (Homo sapiens)
- Metastatic brain tumor - WP2249 (Homo sapiens)
- Mitochondrial complex I inhibition leading to parkinsonian motor deficits - WP4945 (Homo sapiens)
- Nephrotic syndrome - WP4758 (Homo sapiens)
- Neurotransmitter disorders - WP4220 (Homo sapiens)
- Non-small cell lung cancer - WP4255 (Homo sapiens)
- Nonalcoholic fatty liver disease - WP4396 (Homo sapiens)
- Ovarian infertility - WP34 (Homo sapiens)
- PKC-gamma calcium signaling in ataxia - WP4760 (Homo sapiens)
- Pancreatic adenocarcinoma pathway - WP4263 (Homo sapiens)
- Parkinson's disease - WP3638 (Mus musculus)
- Parkinson's disease pathway - WP2371 (Homo sapiens)
- Pathogenic Escherichia coli infection - WP2272 (Homo sapiens)
- Pathways affected in adenoid cystic carcinoma - WP3651 (Homo sapiens)
- Physiological and pathological hypertrophy of the heart - WP1528 (Homo sapiens)
- Pilocytic astrocytoma - WP2253 (Homo sapiens)
- Polycystic kidney disease pathway - WP2571 (Homo sapiens)
- Prader-Willi and Angelman syndrome - WP3998 (Homo sapiens)
- Prion disease pathway - WP3995 (Homo sapiens)
- Retinoblastoma gene in cancer - WP2446 (Homo sapiens)
- Rett syndrome - WP4312 (Homo sapiens)
- Small cell lung cancer - WP4658 (Homo sapiens)
- Spinal cord injury - WP2431 (Homo sapiens)
- Statin inhibition of cholesterol production - WP430 (Homo sapiens)
- Sudden infant death syndrome (SIDS) susceptibility pathways - WP706 (Homo sapiens)
- Synaptic signaling associated with autism spectrum disorder - WP4539 (Homo sapiens)
- T cell modulation in pancreatic cancer - WP5078 (Homo sapiens)
- T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection - WP3863 (Homo sapiens)
- TCA cycle nutrient use and invasiveness of ovarian cancer - WP2868 (Homo sapiens)
- Thyroid hormones production and peripheral downstream signaling effects - WP4746 (Homo sapiens)
- Type 2 papillary renal cell carcinoma - WP4241 (Homo sapiens)
- Type II diabetes mellitus - WP1584 (Homo sapiens)
- Valproic acid pathway - WP3871 (Homo sapiens)
- Vitamin B6-dependent and responsive disorders - WP4228 (Homo sapiens)
- Vitamin D-sensitive calcium signaling in depression - WP4698 (Homo sapiens)
- Wnt signaling in kidney disease - WP3857 (Mus musculus)
- Wnt signaling in kidney disease - WP4150 (Homo sapiens)
- Wnt/beta-catenin signaling in leukemia - WP3658 (Homo sapiens)
How to Contribute
If you know of a pathway that should be added, please contact the administrator. Suggested topics for additional pathways include endocrine and metabolic disease, infectious disease, addiction, immune system disease and neurodevelopmental disorders. Existing pathways in need of improvements:
- Integrated Cancer Pathway
- Nifedipine Activity
- Pilocytic astrocytoma
- Prostate Cancer
- Influenza A virus infection
- Pathogenic Escherichia coli infection
- Ovarian Infertility Genes
- Polycystic kidney disease
- Type II diabetes mellitus
- Physiological and Pathological Hypertrophy of the Heart
Community Members
Authors of Community Pathways
Kristina Hanspers , Julivana , Friederike Ehrhart , Egon Willighagen , Alex Pico , Eric Weitz , Esther Umwamikazi , Aishwarya Iyer , JulietaCosta , Kieran Reidy , ElenaDR , Jolijn Hekma Wierda , Kay Veurink , Clarissa Falempin , Rens Eikelboom , Tom Bausch , Javier Millán Acosta , Olivier Traets , Marvin Martens , Finterly Hu , Pauladewenter , Lars Willighagen , Tooba Abbassi-Daloii , Nathan Salomonis , Thomas Kelder , Jonathan Mélius , Lovnish Thakur , Susan Coort , Denise Slenter , Daniela Digles , Phillip Febbo , Robertbaertsch , Martina Summer-Kutmon , Lauren J. Dupuis , Andika Tan , Ncananfiliz , Isabel Wassink , Oneshin , Zahra Roudbari , Anders Riutta , Irene Hemel , Andra Waagmeester , Anwesha Bohler , Christine Chichester , Jesse Vercoulen , Josien Landman , AAR&Co , Nirupama Benis , Elisson nl , Lora Simons , ChristeldeVries , Chris Evelo , Aaron Caine , Etaglobin , Whom , Agustin Gonzalez-Vicente , Alexander C. Zambon , David Robelin , Marianthi Kalafati , Martijn Van Iersel , Sara Ibrahim , Richard Delava , Penny Nymark , Linda Rieswijk , Ryan Miller , Ingebude , Lobke Meels , Devi , Elisa Cirillo , Ann Friesacher , Izhar Ben-Shlomo , Aaron Hsueh , Vanessa Sousa , Mick Eikelhof , Maartje Levels , Kelly Janssen , Lot Van De Wouw , Jack Youngren , Max Van Son , Deborah Micael , Bruce Conklin , Samuel Sklar , Lars Eijssen , Dana Mustafa , Rik Lahaije , Abhishek , Sharestha Drall , Lisa Martina Held , and Leonie Van De Ven .