Integrated cancer pathway (WP1971)
Homo sapiens
This integrated cancer pathway describes the key mechanisms involved in the development of cancer containing the key prognostic markers and pathogenetic factors. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP1971 CPTAC Assay Portal]
Authors
Sara Ibrahim , Alex Pico , Martijn Van Iersel , Daniela Digles , Kristina Hanspers , Egon Willighagen , Martina Summer-Kutmon , Marvin Martens , and Eric WeitzActivity
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Organisms
Homo sapiensCommunities
DiseasesAnnotations
Pathway Ontology
cancer pathwayDisease Ontology
cancer| Label | Type | Compact URI | Comment |
|---|---|---|---|
| ATF1 | GeneProduct | ensembl:ENSG00000123268 | |
| CDC25B | GeneProduct | ensembl:ENSG00000101224 | |
| CDC25A | GeneProduct | ensembl:ENSG00000164045 | |
| BACH1 | GeneProduct | ensembl:ENSG00000156273 | |
| PLK1 | GeneProduct | ensembl:ENSG00000166851 | |
| MYC | GeneProduct | ensembl:ENSG00000136997 | |
| OCT1 | Protein | ncbigene:5451 | |
| p21 | Protein | ncbigene:1026 | |
| CDK4_HUMAN | Protein | uniprot:P11802 | |
| PUMA | Protein | ncbigene:27113 | |
| ATM_HUMAN | Protein | uniprot:Q13315 | |
| CASP9_HUMAN | Protein | uniprot:P55211 | |
| CASP8_HUMAN | Protein | uniprot:Q14790 | |
| ATR_HUMAN | Protein | uniprot:Q13535 | |
| CDK2_HUMAN | Protein | uniprot:P24941 | |
| CDC2_HUMAN | Protein | uniprot:P06493 | Oncogene |
| P53_HUMAN | Protein | uniprot:P04637 | |
| NOXA1_HUMAN | Protein | uniprot:Q86UR1 | |
| MRE11_HUMAN | Protein | uniprot:P49959 | |
| ASK1 | Protein | ncbigene:4217 | |
| BARD1_HUMAN | Protein | uniprot:Q99728 | |
| CASP3_HUMAN | Protein | uniprot:P42574 | |
| RB_HUMAN | Protein | uniprot:P06400 | |
| BAD_HUMAN | Protein | uniprot:Q92934 | |
| CHK1_HUMAN | Protein | uniprot:O14757 | |
| SMAD2_HUMAN | Protein | uniprot:Q15796 | Tumor supressor |
| SMAD3_HUMAN | Protein | uniprot:P84022 | |
| MSH6_HUMAN | Protein | uniprot:P52701 | |
| AKT1_HUMAN | Protein | uniprot:P31749 | |
| MSH2_HUMAN | Protein | uniprot:P43246 | |
| BCL2_HUMAN | Protein | uniprot:P10415 | |
| MDM2_HUMAN | Protein | uniprot:Q00987 | Oncogene |
| BRCA1_HUMAN | Protein | uniprot:P38398 | |
| STAT1_HUMAN | Protein | uniprot:P42224 | |
| CHK2_HUMAN | Protein | uniprot:O96017 | Phosphorylated |
| BAX_HUMAN | Protein | uniprot:Q07812 | |
| RAD50_HUMAN | Protein | uniprot:Q92878 | |
| MMP1_HUMAN | Protein | uniprot:P03956 | |
| Q8NBS1_HUMAN | Protein | uniprot:Q8NBS1 | |
| JAK1_HUMAN | Protein | uniprot:P23458 | |
| PTEN_HUMAN | Protein | uniprot:P60484 | |
| p15 | Protein | ncbigene:1030 | |
| p27 | Protein | ncbigene:1027 | |
| BLM_HUMAN | Protein | uniprot:P54132 | |
| BRCA1_HUMAN | Protein | uniprot:P38398 | Phosphorylated |
| E2F1_HUMAN | Protein | uniprot:Q01094 |
References
- MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, Patel T. Gastroenterology. 2007 Aug;133(2):647–58. PubMed Europe PMC Scholia
- MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators. Gabriely G, Wurdinger T, Kesari S, Esau CC, Burchard J, Linsley PS, et al. Mol Cell Biol. 2008 Sep;28(17):5369–80. PubMed Europe PMC Scholia
- microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma. Zhao JJ, Lin J, Lwin T, Yang H, Guo J, Kong W, et al. Blood. 2010 Apr 1;115(13):2630–9. PubMed Europe PMC Scholia
- miR-29b regulates migration of human breast cancer cells. Wang C, Bian Z, Wei D, Zhang J guo. Mol Cell Biochem. 2011 Jun;352(1–2):197–207. PubMed Europe PMC Scholia