Polycystic kidney disease pathway (WP2571)
Homo sapiens
A putative PKD pathway proposed in [https://europepmc.org/article/MED/19455193 Torres 2009 (Figure 2)], showing up or down regulated genes. V2R antagonists from [https://en.wikipedia.org/wiki/Vasopressin_receptor_antagonist#Vaptans Wikipedia].
Authors
Egon Willighagen , Martina Summer-Kutmon , Kristina Hanspers , Friederike Ehrhart , Agustin Gonzalez-Vicente , and Eric WeitzActivity
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Organisms
Homo sapiensCommunities
Diseases Renal Genomics PathwaysAnnotations
Pathway Ontology
signaling pathway kidney disease pathwayDisease Ontology
polycystic kidney diseaseCell Type Ontology
kidney cell| Label | Type | Compact URI | Comment |
|---|---|---|---|
| K+ | Metabolite | chebi:29103 | |
| Mozavaptan | Metabolite | chebi:135694 | |
| Cl- | Metabolite | chebi:17996 | |
| Na+ | Metabolite | chebi:29101 | |
| lixivaptan | Metabolite | wikidata:Q6659958 | |
| AMP | Metabolite | chebi:16027 | |
| Ca2+ | Metabolite | chebi:29108 | |
| cAMP | Metabolite | chebi:17489 | |
| Metformin | Metabolite | chebi:6801 | |
| IP3 | Metabolite | chebi:16595 | |
| Triptolide | Metabolite | chebi:9747 | |
| Somatostatin | Metabolite | hmdb:HMDB0013072 | |
| Vasopressin | Metabolite | hmdb:HMDB0001980 | |
| AMP | Metabolite | chebi:16027 | |
| ADP | Metabolite | chebi:16761 | |
| ATP | Metabolite | chebi:15422 | |
| Satavaptan | Metabolite | wikidata:Q7425965 | |
| Tolvaptan | Metabolite | chebi:32246 | |
| FZD1 | GeneProduct | hgnc.symbol:FZD1 | |
| FZD2 | GeneProduct | hgnc.symbol:FZD2 | |
| FZD3 | GeneProduct | hgnc.symbol:FZD3 | |
| FZD4 | GeneProduct | hgnc.symbol:FZD4 | |
| FZD5 | GeneProduct | hgnc.symbol:FZD5 | |
| FZD6 | GeneProduct | hgnc.symbol:FZD6 | |
| FZD7 | GeneProduct | hgnc.symbol:FZD7 | |
| FZD8 | GeneProduct | hgnc.symbol:FZD8 | |
| FZD9 | GeneProduct | hgnc.symbol:FZD9 | |
| FZD10 | GeneProduct | hgnc.symbol:FZD10 | |
| WNT1 | GeneProduct | hgnc.symbol:WNT1 | |
| WNT2 | GeneProduct | hgnc.symbol:WNT2 | |
| WNT2B | GeneProduct | hgnc.symbol:WNT2B | |
| WNT3 | GeneProduct | hgnc.symbol:WNT3 | |
| WNT3A | GeneProduct | hgnc.symbol:WNT3A | |
| WNT4 | GeneProduct | hgnc.symbol:WNT4 | |
| WNT5A | GeneProduct | hgnc.symbol:WNT5A | |
| WNT5B | GeneProduct | hgnc.symbol:WNT5B | |
| WNT6 | GeneProduct | hgnc.symbol:WNT6 | |
| WNT7B | GeneProduct | hgnc.symbol:WNT7B | |
| WNT8A | GeneProduct | hgnc.symbol:WNT8A | |
| WNT8B | GeneProduct | hgnc.symbol:WNT8B | |
| WNT9A | GeneProduct | hgnc.symbol:WNT9A | |
| WNT9B | GeneProduct | hgnc.symbol:WNT9B | |
| WNT10A | GeneProduct | hgnc.symbol:WNT10A | |
| WNT10B | GeneProduct | hgnc.symbol:WNT10B | |
| WNT11 | GeneProduct | hgnc.symbol:WNT11 | |
| WNT16 | GeneProduct | hgnc.symbol:WNT16 | |
| NRAS | GeneProduct | hgnc.symbol:NRAS | |
| TNF | GeneProduct | ensembl:ENSG00000232810 | |
| WNT7A | GeneProduct | hgnc.symbol:WNT7A | |
| KRAS | GeneProduct | hgnc.symbol:KRAS | |
| CCND1 | GeneProduct | ensembl:ENSG00000110092 | |
| IKBKB | GeneProduct | ensembl:ENSG00000104365 | |
| PKD1 | GeneProduct | ensembl:ENSG00000008710 | Also known as PKD1. |
| MTOR | GeneProduct | ensembl:ENSG00000198793 | |
| HRAS | GeneProduct | hgnc.symbol:HRAS | |
| DVL1 | GeneProduct | hgnc.symbol:DVL1 | |
| PRKAA1 | GeneProduct | hgnc.symbol:PRKAA1 | |
| KDR | GeneProduct | hgnc.symbol:KDR | |
| RHEB | GeneProduct | ensembl:ENSG00000106615 | |
| TSC2 | GeneProduct | ensembl:ENSG00000103197 | |
| RSK | GeneProduct | hgnc.symbol:RPS6KA1 | |
| TSC1 | GeneProduct | ensembl:ENSG00000165699 | |
| ERK1 | GeneProduct | ensembl:ENSG00000102882 | |
| MAP2K2 | GeneProduct | hgnc.symbol:MAP2K2 | |
| GSK3B | GeneProduct | hgnc.symbol:GSK3B | |
| PDE1A | GeneProduct | hgnc.symbol:PDE1A | |
| ADCY6 | GeneProduct | hgnc.symbol:ADCY6 | |
| PKA | GeneProduct | ensembl:ENSG00000165059 | |
| TNF | GeneProduct | ensembl:ENSG00000204490 | |
| BRAF | GeneProduct | ensembl:ENSG00000157764 | |
| SRC | GeneProduct | ensembl:ENSG00000197122 | |
| PKD2 | GeneProduct | ensembl:ENSG00000118762 | Also known as PKD2. |
| PLCG2 | GeneProduct | hgnc.symbol:PLCG2 | |
| EGF | GeneProduct | ensembl:ENSG00000138798 | |
| IGF1 | GeneProduct | ensembl:ENSG00000017427 | |
| VEGFB | GeneProduct | ensembl:ENSG00000173511 | |
| CFTR | GeneProduct | hgnc.symbol:CFTR | |
| SSTR2 | GeneProduct | hgnc.symbol:SSTR2 | |
| GNAS | GeneProduct | hgnc.symbol:GNAS | |
| sFRP4 | GeneProduct | ensembl:ENSG00000106483 | |
| LKB1 | GeneProduct | ensembl:ENSG00000118046 | |
| FOS | GeneProduct | hgnc.symbol:FOS | |
| JUN | GeneProduct | ensembl:ENSG00000177606 | |
| MYC | GeneProduct | ensembl:ENSG00000136997 | |
| NKCC1 | GeneProduct | ensembl:ENSG00000064651 | |
| KCNN4 | GeneProduct | hgnc.symbol:KCNN4 | |
| CTNNB1 | GeneProduct | ensembl:ENSG00000168036 | |
| DVL2 | GeneProduct | hgnc.symbol:DVL2 | |
| DVL3 | GeneProduct | hgnc.symbol:DVL3 | |
| GNAI1 | GeneProduct | hgnc.symbol:GNAI1 | |
| GNAI2 | GeneProduct | hgnc.symbol:GNAI2 | |
| GNAI3 | GeneProduct | hgnc.symbol:GNAI3 | |
| GNA11 | GeneProduct | hgnc.symbol:GNA11 | |
| GNAQ | GeneProduct | hgnc.symbol:GNAQ | |
| FLT1 | GeneProduct | hgnc.symbol:FLT1 | |
| ERBB2 | GeneProduct | hgnc.symbol:ERBB2 | |
| IGF1R | GeneProduct | hgnc.symbol:IGF1R | |
| PRKAA2 | GeneProduct | hgnc.symbol:PRKAA2 | |
| PRKAB1 | GeneProduct | hgnc.symbol:PRKAB1 | |
| PRKAB2 | GeneProduct | hgnc.symbol:PRKAB2 | |
| PRKAG1 | GeneProduct | hgnc.symbol:PRKAG1 | |
| PRKAG2 | GeneProduct | hgnc.symbol:PRKAG2 | |
| PRKAG3 | GeneProduct | hgnc.symbol:PRKAG3 |
References
- Autosomal dominant polycystic kidney disease: the last 3 years. Torres VE, Harris PC. Kidney Int. 2009 Jul;76(2):149–68. PubMed Europe PMC Scholia