Physiological and pathological hypertrophy of the heart (WP1528)

Homo sapiens

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Pathways in physiological and pathological hypertrophy of the heart. Largely based on the article from [https://www.ncbi.nlm.nih.gov/pubmed/11714087 Wang et al, 'Signal transduction in cardiac hypertrophy--dissecting compensatory versus pathological pathways utilizing a transgenic approach.] Hypertrohpy of the heart can be a physiological compensation for exercise, but it can also be a pathological compensation for hypertension and stress. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP1528 CPTAC Assay Portal]

Authors

Maartje Levels , Susan Coort , Alex Pico , Kristina Hanspers , Friederike Ehrhart , Egon Willighagen , Andika Tan , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Diseases

Annotations

Disease Ontology

hypertrophic cardiomyopathy heart disease

Cell Type Ontology

cardiac muscle cell

Pathway Ontology

hypertrophic cardiomyopathy pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
PE Metabolite hmdb:HMDB0002182
Calcium Metabolite hmdb:HMDB0000464
MKK3 GeneProduct ncbigene:5606
MYEF2 GeneProduct ncbigene:50804
MAPK14 GeneProduct ncbigene:1432
PRKCB GeneProduct ncbigene:5579
LIFR GeneProduct ncbigene:3977
JNK GeneProduct ncbigene:5599
CAMK2D GeneProduct ncbigene:817
CTF1 GeneProduct ncbigene:1489
JUN GeneProduct ncbigene:3725
PPP3CB GeneProduct ncbigene:5532
PKCE GeneProduct ncbigene:5581
RAC1 GeneProduct ncbigene:5879
EDN1 GeneProduct ncbigene:1906
FOS GeneProduct ncbigene:2353
MAPK11 GeneProduct ncbigene:5600
RHOA GeneProduct ncbigene:387
NFAT3 GeneProduct ncbigene:4776
PPP3CA GeneProduct ncbigene:5530
STAT3 GeneProduct ncbigene:6774
GATA4 GeneProduct ncbigene:2626
MAPK1 GeneProduct ncbigene:5594
AGT GeneProduct ncbigene:183
IL6ST GeneProduct ncbigene:3572
CALM1 Protein ncbigene:801

References

  1. Cardiotrophin-1 activates a distinct form of cardiac muscle cell hypertrophy. Assembly of sarcomeric units in series VIA gp130/leukemia inhibitory factor receptor-dependent pathways. Wollert KC, Taga T, Saito M, Narazaki M, Kishimoto T, Glembotski CC, et al. J Biol Chem. 1996 Apr 19;271(16):9535–45. PubMed Europe PMC Scholia
  2. Cardiotrophin-1 and the role of gp130-dependent signaling pathways in cardiac growth and development. Wollert KC, Chien KR. J Mol Med (Berl). 1997 Jul;75(7):492–501. PubMed Europe PMC Scholia
  3. Cardiac hypertrophy induced by mitogen-activated protein kinase kinase 7, a specific activator for c-Jun NH2-terminal kinase in ventricular muscle cells. Wang Y, Su B, Sah VP, Brown JH, Han J, Chien KR. J Biol Chem. 1998 Mar 6;273(10):5423–6. PubMed Europe PMC Scholia
  4. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Molkentin JD, Lu JR, Antos CL, Markham B, Richardson J, Robbins J, et al. Cell. 1998 Apr 17;93(2):215–28. PubMed Europe PMC Scholia
  5. Calcineurin and human heart failure. Lim HW, Molkentin JD. Nat Med. 1999 Mar;5(3):246–7. PubMed Europe PMC Scholia
  6. Prevention of cardiac hypertrophy by calcineurin inhibition: hope or hype? Olson EN, Molkentin JD. Circ Res. 1999 Apr 2;84(6):623–32. PubMed Europe PMC Scholia
  7. Signaling pathways for cardiac hypertrophy and failure. Hunter JJ, Chien KR. N Engl J Med. 1999 Oct 21;341(17):1276–83. PubMed Europe PMC Scholia
  8. Signal transduction during cardiac hypertrophy: the role of G alpha q, PLC beta I, and PKC. Jalili T, Takeishi Y, Walsh RA. Cardiovasc Res. 1999 Oct;44(1):5–9. PubMed Europe PMC Scholia
  9. Small guanine nucleotide-binding proteins and myocardial hypertrophy. Clerk A, Sugden PH. Circ Res. 2000 May 26;86(10):1019–23. PubMed Europe PMC Scholia
  10. Transgenic overexpression of constitutively active protein kinase C epsilon causes concentric cardiac hypertrophy. Takeishi Y, Ping P, Bolli R, Kirkpatrick DL, Hoit BD, Walsh RA. Circ Res. 2000 Jun 23;86(12):1218–23. PubMed Europe PMC Scholia
  11. Advances in the molecular mechanisms of heart failure. MacLellan WR. Curr Opin Cardiol. 2000 May;15(3):128–35. PubMed Europe PMC Scholia
  12. Calcineurin and beyond: cardiac hypertrophic signaling. Molkentin JD. Circ Res. 2000 Oct 27;87(9):731–8. PubMed Europe PMC Scholia
  13. The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice. Bueno OF, De Windt LJ, Tymitz KM, Witt SA, Kimball TR, Klevitsky R, et al. EMBO J. 2000 Dec 1;19(23):6341–50. PubMed Europe PMC Scholia
  14. Signal transduction in cardiac hypertrophy--dissecting compensatory versus pathological pathways utilizing a transgenic approach. Wang Y. Curr Opin Pharmacol. 2001 Apr;1(2):134–40. PubMed Europe PMC Scholia
  15. Regulation of cardiac hypertrophy by intracellular signalling pathways. Heineke J, Molkentin JD. Nat Rev Mol Cell Biol. 2006 Aug;7(8):589–600. PubMed Europe PMC Scholia