Welcome to the Renal Genomics Community at WikiPathways
This page highlights WikiPathways content related to renal biology and disease. Most available pathways lack tissue/cell specificity and are of limited usefulness in highly differentiated organs such as the kidney. In order to produce quality renal genomics data, new and updated kidney-specific pathways are needed. This page offers an opportunity for renal physiologists to participate in creating, testing and curating new pathways, thereby contributing with modern methodology to integrate the renal knowledge-base.
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Community Pathways
Table FiltersThis community helps to curate 30 pathways:
- ACE inhibitor pathway - WP1033 (Bos taurus)
- ACE inhibitor pathway - WP554 (Homo sapiens)
- Angiotensin II signaling (acute) in thick ascending limbs - WP3887 (Rattus norvegicus)
- Clear cell renal cell carcinoma pathways - WP4018 (Homo sapiens)
- Distal convoluted tubule 1 (DCT1) cell - WP4183 (Mus musculus)
- Endothelin pathways - WP2197 (Homo sapiens)
- Endothelin pathways - WP3246 (Bos taurus)
- Fructose metabolism in proximal tubules - WP3894 (Rattus norvegicus)
- HIPK2 in kidney fibrosis - WP4751 (Homo sapiens)
- Hereditary leiomyomatosis and renal cell carcinoma pathway - WP4206 (Homo sapiens)
- Hexoses metabolism in proximal tubules - WP3916 (Rattus norvegicus)
- Lipid droplet metabolism - WP3901 (Rattus norvegicus)
- MET in type 1 papillary renal cell carcinoma - WP4205 (Homo sapiens)
- Nephrotic syndrome - WP4758 (Homo sapiens)
- Polycystic kidney disease pathway - WP2571 (Homo sapiens)
- Polyol pathway - WP1265 (Mus musculus)
- Polyol pathway - WP1303 (Rattus norvegicus)
- Polyol pathway - WP690 (Homo sapiens)
- Primary focal segmental glomerulosclerosis (FSGS) - WP2572 (Homo sapiens)
- Primary focal segmental glomerulosclerosis (FSGS) - WP2573 (Mus musculus)
- Primary focal segmental glomerulosclerosis (FSGS) - WP3233 (Bos taurus)
- Proximal tubule transporters - WP3881 (Rattus norvegicus)
- Renin-angiotensin system - WP376 (Rattus norvegicus)
- Thick ascending limb transporters - WP3882 (Rattus norvegicus)
- Tumor suppressor activity of SMARCB1 - WP4204 (Homo sapiens)
- Type 2 papillary renal cell carcinoma - WP4241 (Homo sapiens)
- Vitamin D metabolism - WP1531 (Homo sapiens)
- Vitamin D metabolism - WP3162 (Bos taurus)
- Wnt signaling in kidney disease - WP3857 (Mus musculus)
- Wnt signaling in kidney disease - WP4150 (Homo sapiens)
How to Contribute
You are invited to test and curate existing pathways as well as to create new ones. All suggestions and contributions are welcome, contact Agustin Gonzalez-Vicente if interested in adding pathways. Suggested topics for new pathways are Membranoproliferative Glomerulonephritis type II, Acute Kidney Injury,, Chronic Kidney Disease, Diabetic Nephropathy, Kidney Transplants and Rejection, Mitochondria in Renal Disease, Membranous Nephropathy, Immune System and the Kidney, Renovascular Hypertension, Salt-Sensitive Hypertension. Some useful resources related to kidney biology are
- Kidney Precision Medicine Project (KPMP): The KPMP actively engages academics, industry, and the broader scientific community as it works to deepen understanding of the kidneys.
- Epithelial System Biology Laboratory(ESBL): download data and access computational tools.
- Kidney System Biology Project (ESBL): renal epithelial transcriptome and proteome databases.
Community Members
Authors of Community Pathways
Agustin Gonzalez-Vicente , Thomas Kelder , Egon Willighagen , Christine Chichester , Kristina Hanspers , Martina Summer-Kutmon , Eric Weitz , Caroline F. Thorn , Jinwook.seo , Alex Pico , Martijn Van Iersel , Nuno , Denise Slenter , Susan Coort , Friederike Ehrhart , Finterly Hu , Sabine Daemen , Mireille Sthijns , Lauren J. Dupuis , Elisson nl , Daniela Digles , Pieter Giesbertz , Deborah Micael , Zahra Roudbari , Andika Tan , Max Van Son , Lars Willighagen , Rishi , Mark Van Grinsven , Chris Evelo , Lucia Ribeiro , Mingye Wang , and AAR&Co .