Vitamin A and carotenoid metabolism (WP716)

Homo sapiens

Authors

Andra Waagmeester , Paolo Romano , Alex Pico , Chris Evelo , Susan Coort , Thomas Kelder , Kristina Hanspers , Allan Kuchinsky , Anwesha Bohler , Daniela Digles , Egon Willighagen , Martina Summer-Kutmon , Zahra Roudbari , Friederike Ehrhart , Denise Slenter , Eric Weitz , and Conroy lipids

Activity

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Cited In

• Reconstructed Human Skin with Hypodermis Shows Essential Role of Adipose Tissue in Skin Metabolism (2024).
• Interactive neuroinflammation pathways and transcriptomics-based identification of drugs and chemical compounds for schizophrenia (2023).
• New Insight Into Mechanisms of Hepatic Encephalopathy: An Integrative Analysis Approach to Identify Molecular Markers and Therapeutic Targets.
• Integrative epigenetic profiling analysis identifies DNA methylation changes associated with chronic alcohol consumption (2015).

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Organisms

Homo sapiens

Communities

Micronutrients

Annotations

Pathway Ontology

retinol metabolic pathway metabolic pathway of cofactors, vitamins, nutrients vitamin A and metabolites signaling pathway

Cell Type Ontology

enterocyte

References

1. Separation and identification of carotenoids and their oxidation products in the extracts of human plasma. Khachik F, Beecher GR, Goli MB, Lusby WR, Smith JC Jr. Anal Chem. 1992 Sep 15;64(18):2111–22. PubMed Europe PMC Scholia
2. Antioxidant functions of vitamins. Vitamins E and C, beta-carotene, and other carotenoids. Sies H, Stahl W, Sundquist AR. Ann N Y Acad Sci. 1992 Sep 30;669:7–20. PubMed Europe PMC Scholia
3. Plasma carotenoid response to chronic intake of selected foods and beta-carotene supplements in men. Micozzi MS, Brown ED, Edwards BK, Bieri JG, Taylor PR, Khachik F, et al. Am J Clin Nutr. 1992 Jun;55(6):1120–5. PubMed Europe PMC Scholia
4. Biological actions of carotenoids. Bendich A, Olson JA. FASEB J. 1989 Jun;3(8):1927–32. PubMed Europe PMC Scholia
5. Interrelationships among liposoluble vitamins in ruminants. Hidiroglou M, Williams CJ. Am J Vet Res. 1986 Aug;47(8):1767–71. PubMed Europe PMC Scholia
6. Carotenoids in the human macula and whole retina. Handelman GJ, Dratz EA, Reay CC, van Kuijk JG. Invest Ophthalmol Vis Sci. 1988 Jun;29(6):850–5. PubMed Europe PMC Scholia
7. Seasonal and sex-related variations in six serum carotenoids, retinol, and alpha-tocopherol. Olmedilla B, Granado F, Blanco I, Rojas-Hidalgo E. Am J Clin Nutr. 1994 Jul;60(1):106–10. PubMed Europe PMC Scholia
8. Acute phase response and plasma carotenoid concentrations in older women: findings from the nun study. Boosalis MG, Snowdon DA, Tully CL, Gross MD. Nutrition. 1996;12(7–8):475–8. PubMed Europe PMC Scholia
9. Influence of using different sources of carotenoid data in epidemiologic studies. VandenLangenberg GM, Brady WE, Nebeling LC, Block G, Forman M, Bowen PE, et al. J Am Diet Assoc. 1996 Dec;96(12):1271–5. PubMed Europe PMC Scholia
10. Vitamin A deficiency and nocturnal vision in teenagers with cystic fibrosis. Huet F, Semama D, Maingueneau C, Charavel A, Nivelon JL. Eur J Pediatr. 1997 Dec;156(12):949–51. PubMed Europe PMC Scholia
11. Vitamin D analogs affect the uptake and metabolism of retinol by human epidermal keratinocytes in culture. Törmä H, Rollman O, Binderup L, Michaelsson G. J Investig Dermatol Symp Proc. 1996 Apr;1(1):49–53. PubMed Europe PMC Scholia
12. Lycopene and 1,25-dihydroxyvitamin D3 cooperate in the inhibition of cell cycle progression and induction of differentiation in HL-60 leukemic cells. Amir H, Karas M, Giat J, Danilenko M, Levy R, Yermiahu T, et al. Nutr Cancer. 1999;33(1):105–12. PubMed Europe PMC Scholia
13. Vitamin A antagonizes calcium response to vitamin D in man. Johansson S, Melhus H. J Bone Miner Res. 2001 Oct;16(10):1899–905. PubMed Europe PMC Scholia
14. Gene expression regulation by retinoic acid. Balmer JE, Blomhoff R. J Lipid Res. 2002 Nov;43(11):1773–808. PubMed Europe PMC Scholia
15. Relation of elevated serum alanine aminotransferase activity with iron and antioxidant levels in the United States. Ruhl CE, Everhart JE. Gastroenterology. 2003 Jun;124(7):1821–9. PubMed Europe PMC Scholia
16. Preliminary identification of carotenoids in malignant and benign neoplasms of the breast and surrounding fatty tissue. Czeczuga-Semeniuk E, Wołczyński S, Markiewicz W. Neoplasma. 2003;50(4):280–6. PubMed Europe PMC Scholia
17. Identification of all-trans-retinol:all-trans-13,14-dihydroretinol saturase. Moise AR, Kuksa V, Imanishi Y, Palczewski K. J Biol Chem. 2004 Nov 26;279(48):50230–42. PubMed Europe PMC Scholia
18. Metabolism and transactivation activity of 13,14-dihydroretinoic acid. Moise AR, Kuksa V, Blaner WS, Baehr W, Palczewski K. J Biol Chem. 2005 Jul 29;280(30):27815–25. PubMed Europe PMC Scholia
19. Identification and characterization of a novel mouse peroxisome proliferator-activated receptor alpha-regulated and starvation-induced gene, Ppsig. Sun Y, Ng L, Lam W, Lo CKC, Chan PT, Yuen YL, et al. Int J Biochem Cell Biol. 2008;40(9):1775–91. PubMed Europe PMC Scholia
20. Pathway enrichment based on text mining and its validation on carotenoid and vitamin A metabolism. Waagmeester A, Pezik P, Coort S, Tourniaire F, Evelo C, Rebholz-Schuhmann D. OMICS. 2009 Oct;13(5):367–79. PubMed Europe PMC Scholia