Cell cycle (WP179)

Homo sapiens

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The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a cell, including the detection and repair of genetic damage as well as the prevention of uncontrolled cell division. Two key classes of regulatory molecules, cyclins and cyclin-dependent kinases (CDKs), determine a cell's progress through the cell cycle. Sources: [http://en.wikipedia.org/wiki/Cell_cycle Wikipedia:Cell cycle], [http://www.genome.ad.jp/kegg/pathway/hsa/hsa04110.html KEGG]. Protein phosphorylation sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP179 CPTAC Assay Portal]

Authors

Nathan Salomonis , Susan Coort , Iliana Campillo Sach , Bruce Conklin , Sergey Dmitriev , Badrul Yahaya , Thomas Kelder , Martijn Van Iersel , Alex Pico , Christine Chichester , Martina Summer-Kutmon , Josip , Kristina Hanspers , Denise Slenter , Egon Willighagen , Eric Weitz , and Friederike Ehrhart

Activity

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Cited In

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Organisms

Homo sapiens

Communities

CPTAC PancCanNet

Annotations

Pathway Ontology

cell cycle pathway, mitotic

Participants
Query Drugst.One

Label Type Compact URI Comment
CDC7 GeneProduct ensembl:ENSG00000097046 CDC7L1; CDC7 cell division cycle 7-like 1 (S. cerevisiae) [EC:2.7.1.-]
CDK7 GeneProduct ensembl:ENSG00000134058 CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
PLK1 GeneProduct ensembl:ENSG00000166851 PLK; polo-like kinase (Drosophila) [EC:2.7.1.-]
CDKN2A GeneProduct ensembl:ENSG00000147889
MAD2L2 GeneProduct ensembl:ENSG00000116670 MAD2L2; MAD2 mitotic arrest deficient-like 2 (yeast)
PCNA GeneProduct ensembl:ENSG00000132646 PCNA; proliferating cell nuclear antigen
CDK2 GeneProduct ensembl:ENSG00000123374 CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
GSK3B GeneProduct ensembl:ENSG00000082701 GSK3B; glycogen synthase kinase 3 beta [EC:2.7.1.37]
ESPL1 GeneProduct ensembl:ENSG00000135476 ESPL1; extra spindle poles like 1 (S. cerevisiae
MCM2 GeneProduct ensembl:ENSG00000073111
TP53 GeneProduct ensembl:ENSG00000141510
CDC25B GeneProduct ensembl:ENSG00000101224 CDC25C; cell division cycle 25C [EC:3.1.3.48]
CC14B GeneProduct ensembl:ENSG00000081377 CDC14B; CDC14 cell division cycle 14 homolog B (S. cerevisiae
CCNA1 GeneProduct ensembl:ENSG00000133101 CCNA1; cyclin A1
CCNA2 GeneProduct ensembl:ENSG00000145386 CCNA2; cyclin A2
RB1 GeneProduct ensembl:ENSG00000139687 RB1; retinoblastoma 1 (including osteosarcoma)
HDAC1 GeneProduct ensembl:ENSG00000116478 HDAC1; histone deacetylase 1
MAD1L1 GeneProduct ensembl:ENSG00000002822 MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast
RBL2 GeneProduct ensembl:ENSG00000103479 RB1; retinoblastoma 1 (including osteosarcoma)
RBL1 GeneProduct ensembl:ENSG00000080839 RB1; retinoblastoma 1 (including osteosarcoma)
CDC45 GeneProduct ensembl:ENSG00000093009 CDC45L; CDC45 cell division cycle 45-like (S. cerevisiae)
ATM GeneProduct ensembl:ENSG00000149311 ATM; ataxia telangiectasia mutated (includes complementation groups A C and D) [EC:2.7.1.37]
TGFB1 GeneProduct ensembl:ENSG00000105329
CCNH GeneProduct ensembl:ENSG00000134480 CCNH; cyclin H
PTTG1 GeneProduct ensembl:ENSG00000164611 PTTG1; pituitary tumor-transforming
CHK2 GeneProduct ncbigene:11200 CHEK2; CHK2 checkpoint homolog (S. pombe) [EC:2.7.1.-]
CDK1 GeneProduct ensembl:ENSG00000170312 CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.-
PKMYT1 GeneProduct ensembl:ENSG00000127564 PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinas
CDC20 GeneProduct ncbigene:991 CDC20; CDC20 cell division cycle 20 homolog (S. cerevisiae
SMAD4 GeneProduct ensembl:ENSG00000141646 MADH4; MAD mothers against decapentaplegic homolog 4 (Drosophila)
CCNE1 GeneProduct ensembl:ENSG00000105173 CCNE1; cyclin E
CDC25C GeneProduct ensembl:ENSG00000158402 CDC25B; cell division cycle 25B [EC:3.1.3.48]
ABL1 GeneProduct ensembl:ENSG00000097007 ABL1; v-abl Abelson murine leukemia viral oncogene homolog 1 [EC:2.7.1.112
RB1 GeneProduct ensembl:ENSG00000139687 RB1; retinoblastoma 1 (including osteosarcoma)
CCNE2 GeneProduct ensembl:ENSG00000175305 CCNE2; cyclin E
ATR GeneProduct ensembl:ENSG00000175054 ATR; ataxia telangiectasia and Rad3 related
SFN GeneProduct ensembl:ENSG00000175793 YWHAG; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptid
HDAC2 GeneProduct ensembl:ENSG00000196591 HDAC2; histone deacetylase 2
PTTG2 GeneProduct ensembl:ENSG00000250254 PTTG2; pituitary tumor-transforming
FZR1 GeneProduct ensembl:ENSG00000105325
SKP1 GeneProduct ensembl:ENSG00000113558
YWHAB GeneProduct ncbigene:7529
CDK2 GeneProduct ensembl:ENSG00000123374 CDK2; cyclin-dependent kinase 2 [EC:2.7.1.-]
GADD45A GeneProduct ensembl:ENSG00000116717
CDK6 GeneProduct ensembl:ENSG00000105810 CDK6; cyclin-dependent kinase 6 [EC:2.7.1.-]
CDC6 GeneProduct ensembl:ENSG00000094804 CDC6; CDC6 cell division cycle 6 homolog (S. cerevisiae
EP300 GeneProduct ensembl:ENSG00000100393 EP300; E1A binding protein p300
CDKN1C GeneProduct ensembl:ENSG00000129757 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
SKP2 GeneProduct ensembl:ENSG00000145604 SKP2; S-phase kinase-associated protein 2 (p45
CCND2 GeneProduct ensembl:ENSG00000118971 CCND2; cyclin D2
BUB3 GeneProduct ensembl:ENSG00000154473 MAD2L1; MAD2 mitotic arrest deficient-like 1 (yeast)
YWHAE GeneProduct ncbigene:7531
RB1 GeneProduct ensembl:ENSG00000139687
YWHAH GeneProduct ncbigene:7533
CCNB3 GeneProduct ensembl:ENSG00000147082 CCNB3; cyclin B
YWHAQ GeneProduct ncbigene:10971
CC14A GeneProduct ensembl:ENSG00000079335 CDC14A; CDC14 cell division cycle 14 homolog A (S. cerevisiae
YWHAZ GeneProduct ncbigene:7534
DBF4A GeneProduct ensembl:ENSG00000006634 ASK; activator of S phase kinas
MCM3 GeneProduct ensembl:ENSG00000112118
WEE1 GeneProduct ensembl:ENSG00000166483 WEE1; WEE1+ homolog (S. pombe) [EC:2.7.1.112]
MCM4 GeneProduct ensembl:ENSG00000104738
MCM5 GeneProduct ensembl:ENSG00000100297
CDK4 GeneProduct ensembl:ENSG00000135446 CDK4; cyclin-dependent kinase 4 [EC:2.7.1.-]
MCM6 GeneProduct ensembl:ENSG00000076003
PRKDC GeneProduct ensembl:ENSG00000253729 PRKDC; protein kinase DNA-activated catalytic polypeptide [EC:2.7.1.37]
MCM7 GeneProduct ensembl:ENSG00000166508
ANAPC10 GeneProduct ensembl:ENSG00000164162
ORC1 GeneProduct ensembl:ENSG00000085840
CDKN1A GeneProduct ensembl:ENSG00000124762
ORC2 GeneProduct ensembl:ENSG00000115942
CCNA2 GeneProduct ensembl:ENSG00000145386 CCNA2; cyclin A2
ORC3 GeneProduct ensembl:ENSG00000135336
SMAD3 GeneProduct ensembl:ENSG00000166949 MADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila)
ORC4 GeneProduct ensembl:ENSG00000115947
SMC3 GeneProduct ensembl:ENSG00000108055 SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
ORC5 GeneProduct ensembl:ENSG00000164815
MDM2 GeneProduct ensembl:ENSG00000135679 MDM2; Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse)
ORC6 GeneProduct ensembl:ENSG00000091651
SMAD2 GeneProduct ensembl:ENSG00000175387 MADH3; MAD mothers against decapentaplegic homolog 3 (Drosophila)
BUB1 GeneProduct ensembl:ENSG00000169679 BUB1; BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) [EC:2.7.1.-]
TGFB2 GeneProduct ensembl:ENSG00000092969
CCND3 GeneProduct ensembl:ENSG00000112576 CCND3; cyclin D3
TGFB3 GeneProduct ensembl:ENSG00000119699
CCNB2 GeneProduct ensembl:ENSG00000157456 CCNB2; cyclin B2
RBL1 GeneProduct ensembl:ENSG00000080839
YWHAG GeneProduct ncbigene:7532
E2F4 GeneProduct ensembl:ENSG00000205250
CCNB1 GeneProduct ensembl:ENSG00000134057 CCNB1; cyclin B1
E2F5 GeneProduct ensembl:ENSG00000133740
CDK1 GeneProduct ensembl:ENSG00000170312 CDC2; cell division cycle 2 G1 to S and G2 to M [EC:2.7.1.-
TFDP1 GeneProduct ensembl:ENSG00000198176
CHK1 GeneProduct ncbigene:1111 CHEK1; CHK1 checkpoint homolog (S. pombe) [EC:2.7.1.-]
TFDP2 GeneProduct ensembl:ENSG00000114126
CDKN2A GeneProduct ensembl:ENSG00000147889
MYC GeneProduct ensembl:ENSG00000136997
CCNA1 GeneProduct ensembl:ENSG00000133101 CCNA1; cyclin A1
ZBTB17 GeneProduct ensembl:ENSG00000116809
CDKN2B GeneProduct ensembl:ENSG00000147883
CDKN2C GeneProduct ensembl:ENSG00000123080
CDKN2D GeneProduct ensembl:ENSG00000129355
CCND1 GeneProduct ensembl:ENSG00000110092 CCND3; cyclin D3
CDKN1B GeneProduct ensembl:ENSG00000111276 CDKN1A; cyclin-dependent kinase inhibitor 1A (p21 Cip1)
CUL1 GeneProduct ensembl:ENSG00000055130
RBX1 GeneProduct ensembl:ENSG00000100387
E2F1 GeneProduct ensembl:ENSG00000101412 E2F1; E2F transcription factor 1
E2F2 GeneProduct ensembl:ENSG00000007968 E2F2; E2F transcription factor 2
TFDP1 GeneProduct ensembl:ENSG00000198176 TFDP1; transcription factor Dp-1
E2F3 GeneProduct ensembl:ENSG00000112242 E2F3; E2F transcription factor 3
TFDP2 GeneProduct ensembl:ENSG00000114126 TFDP1; transcription factor Dp-1
E2F4 GeneProduct ensembl:ENSG00000205250 E2F4; E2F transcription factor 4 p107/p130-binding
E2F5 GeneProduct ensembl:ENSG00000133740 E2F5; E2F transcription factor 5 p130-binding
TFDP1 GeneProduct ensembl:ENSG00000198176 TFDP1; transcription factor Dp-1
TFDP2 GeneProduct ensembl:ENSG00000114126 TFDP1; transcription factor Dp-1
GADD45B GeneProduct ensembl:ENSG00000099860
GADD45G GeneProduct ensembl:ENSG00000130222
CDC25A GeneProduct ensembl:ENSG00000164045 PRKDC; protein kinase DNA-activated catalytic polypeptide [EC:2.7.1.37]
TTK GeneProduct ensembl:ENSG00000112742 BUB1B; BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast) [EC:2.7.1.-]
MD1L1 GeneProduct ensembl:ENSG00000002822 MAD1L1; MAD1 mitotic arrest deficient-like 1 (yeast
SMC1B GeneProduct ensembl:ENSG00000077935 SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
SMC1A GeneProduct ensembl:ENSG00000072501 SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
STAG1 GeneProduct ensembl:ENSG00000118007 SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
STAG2 GeneProduct ensembl:ENSG00000101972 SMC1L1; SMC1 structural maintenance of chromosomes 1-like 1 (yeast
RAD21 GeneProduct ensembl:ENSG00000164754 ESPL1; extra spindle poles like 1 (S. cerevisiae
WEE2 GeneProduct ensembl:ENSG00000214102 WEE1; WEE1+ homolog (S. pombe) [EC:2.7.1.112]
ANAPC13 GeneProduct ensembl:ENSG00000129055
ANAPC2 GeneProduct ensembl:ENSG00000176248
ANAPC4 GeneProduct ensembl:ENSG00000053900
ANAPC5 GeneProduct ensembl:ENSG00000089053
ANAPC7 GeneProduct ensembl:ENSG00000196510
ANAPC11 GeneProduct ensembl:ENSG00000141552
ANAPC1 GeneProduct ensembl:ENSG00000153107
CDC23 GeneProduct ensembl:ENSG00000094880
CDC16 GeneProduct ensembl:ENSG00000130177
CDC27 GeneProduct ensembl:ENSG00000004897
CDC20 GeneProduct ncbigene:991 CDC20; CDC20 cell division cycle 20 homolog (S. cerevisiae
ANAPC10 GeneProduct ensembl:ENSG00000164162
ANAPC13 GeneProduct ensembl:ENSG00000129055
ANAPC2 GeneProduct ensembl:ENSG00000176248
ANAPC4 GeneProduct ensembl:ENSG00000053900
ANAPC5 GeneProduct ensembl:ENSG00000089053
ANAPC7 GeneProduct ensembl:ENSG00000196510
ANAPC11 GeneProduct ensembl:ENSG00000141552
ANAPC1 GeneProduct ensembl:ENSG00000153107
CDC23 GeneProduct ensembl:ENSG00000094880
CDC16 GeneProduct ensembl:ENSG00000130177
CDC27 GeneProduct ensembl:ENSG00000004897
SKP1 GeneProduct ensembl:ENSG00000113558
SKP2 GeneProduct ensembl:ENSG00000105810 SKP2; S-phase kinase-associated protein 2 (p45
CUL1 GeneProduct ensembl:ENSG00000055130
RBX1 GeneProduct ensembl:ENSG00000100387
ORC1 GeneProduct ensembl:ENSG00000085840 SKP2; S-phase kinase-associated protein 2 (p45
ORC2 GeneProduct ensembl:ENSG00000115942 SKP2; S-phase kinase-associated protein 2 (p45
ORC3 GeneProduct ensembl:ENSG00000135336 SKP2; S-phase kinase-associated protein 2 (p45
ORC4 GeneProduct ensembl:ENSG00000115947 SKP2; S-phase kinase-associated protein 2 (p45
ORC5 GeneProduct ensembl:ENSG00000164815 SKP2; S-phase kinase-associated protein 2 (p45
ORC6 GeneProduct ensembl:ENSG00000091651 SKP2; S-phase kinase-associated protein 2 (p45
MCM2 GeneProduct ensembl:ENSG00000073111 SKP2; S-phase kinase-associated protein 2 (p45
MCM3 GeneProduct ensembl:ENSG00000112118 SKP2; S-phase kinase-associated protein 2 (p45
MCM4 GeneProduct ensembl:ENSG00000104738 SKP2; S-phase kinase-associated protein 2 (p45
MCM5 GeneProduct ensembl:ENSG00000100297 SKP2; S-phase kinase-associated protein 2 (p45
MCM6 GeneProduct ensembl:ENSG00000076003 SKP2; S-phase kinase-associated protein 2 (p45
MCM7 GeneProduct ensembl:ENSG00000166508 SKP2; S-phase kinase-associated protein 2 (p45

References

  1. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, et al. Science. 1998 Sep 11;281(5383):1677–9. PubMed Europe PMC Scholia
  2. PhosphoSitePlus, 2014: mutations, PTMs and recalibrations. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E. Nucleic Acids Res. 2015 Jan;43(Database issue):D512-20. PubMed Europe PMC Scholia