Fatty acid beta-oxidation (WP143)

Homo sapiens

Complete fatty acid beta-oxidation pathway for saturated and unsaturated fatty acids. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP143 CPTAC Assay Portal]

Authors

Michiel Adriaens , Chris Evelo , Susan Coort , Patrick Ahles , Ferry Jagers , Adrien Defay , Alex Pico , Egon Willighagen , Martina Summer-Kutmon , Denise Slenter , Priyanka K , Kristina Hanspers , Licong , and Eric Weitz

Activity

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Cited In

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Organisms

Homo sapiens

Communities

CPTAC Lipids and LIPID MAPS Serious Request 2024 - MetaKids

Annotations

Pathway Ontology

fatty acid metabolic pathway fatty acid beta degradation pathway fatty acid degradation pathway

Disease Ontology

lipid metabolism disorder

Participants

Label Type Compact URI Comment
trans,cis-Lauro-2,6-dienoyl-CoA Metabolite chebi:28387
3-Oxododexanoyl-CoA Metabolite pubchem.compound:11966169
Fatty Acid Metabolite chebi:35366
Glutarate Metabolite pubchem.compound:743
Trans-Oct-2-enoyl-CoA Metabolite chebi:27537
Myristoyl-CoA Metabolite chebi:15532
(S)-3-Hydroxytetradecanoyl-CoA Metabolite chebi:27466
Acetyl-CoA Metabolite cas:72-89-9
Glutaryl-CoA Metabolite chebi:15524
Glyceraldehyde-3-Phosphate Metabolite cas:591-57-1
2-trans-dodecenoyl-CoA Metabolite chebi:15471
Glycerol Metabolite cas:56-81-5
cis,cis-3,6-Dodecadienoyl-CoA Metabolite chebi:28002
Trans-Dec-2-enoyl-CoA Metabolite chebi:10723
3-Oxo-octanoyl-CoA Metabolite chebi:28264
3-Oxohexanoyl-CoA Metabolite chebi:27648
2-trans-4-cis-decadienoyl-CoA Metabolite chebi:29119
Butanoyl-CoA Metabolite chebi:15517
Decanoyl-CoA Metabolite chebi:28493
Linoleoyl-CoA Metabolite cas:40757-80-0
3-Oxopalmitoyl-CoA Metabolite chebi:15491
Dihydroxyacetone Phosphate Metabolite cas:57-04-5
Trans-Hex-2-enoyl-CoA Metabolite chebi:28706
(S)-3-Hydroxyhexadecanoyl-CoA Metabolite chebi:27402
(S)-3-Hydroxybutanoyl-CoA Metabolite chebi:15453
Lauroyl-CoA Metabolite cas:6244-92-4
Hexanoyl-CoA Metabolite chebi:27540
L-Glycerol-3-Phosphate Metabolite chebi:15978
Acyl-CoA Metabolite chebi:17984
(S)-3-Hydroxydecanoyl-CoA Metabolite chebi:28325
(S)-3-Hydroxyoctanoyl-CoA Metabolite chebi:28632
Palmitoyl-CoA Metabolite chebi:15525
Acetoacetyl-CoA Metabolite cas:1420-36-6
3-trans-decenoyl-CoA Metabolite chebi:29126
Triacylglycerol Metabolite chebi:17855
HADHA GeneProduct ncbigene:3030
ACADM GeneProduct ncbigene:34
HADHB GeneProduct ncbigene:3032
PNPLA2 GeneProduct ncbigene:57104
CPT2 GeneProduct ncbigene:1376
ACADS GeneProduct ncbigene:35
DCI GeneProduct ncbigene:1632
ECHS1 GeneProduct ncbigene:1892
GCDH GeneProduct ncbigene:2639
HADHSC GeneProduct ncbigene:3033
ACADVL GeneProduct ncbigene:37
GPD2 GeneProduct ncbigene:2820
ACSL5 GeneProduct ncbigene:51703
DLD GeneProduct ncbigene:1738
ACAS2 GeneProduct ncbigene:55902
TPI1 GeneProduct ncbigene:7167
GK2 GeneProduct ncbigene:2712
ACSL1 GeneProduct ncbigene:2180
DECR1 GeneProduct ncbigene:1666
LIPC GeneProduct ncbigene:3990
SLC25A20 GeneProduct ncbigene:788
ACADL GeneProduct ncbigene:33
CRAT GeneProduct ncbigene:1384
LIPE GeneProduct ncbigene:3991
ACSL6 GeneProduct ncbigene:23305
CPT1A GeneProduct ncbigene:1374
CPT1B GeneProduct ncbigene:1375
ACSL4 GeneProduct ncbigene:2182
GK GeneProduct ncbigene:2710
LIPF GeneProduct ncbigene:8513
CHKB GeneProduct ncbigene:1120
ACAT1 GeneProduct ncbigene:38
ACSL3 GeneProduct ncbigene:2181
LPL GeneProduct ncbigene:4023

References

  1. Enzymes of fatty acid beta-oxidation in developing brain. Reichmann H, Maltese WA, DeVivo DC. J Neurochem. 1988 Aug;51(2):339–44. PubMed Europe PMC Scholia