Fatty acid biosynthesis (WP357)
Homo sapiens
The production of fatty acids from acetyl-CoA and NADPH through the use of enzymes known as fatty acid synthases is referred to as fatty acid synthesis. This biological process occurs within the cytoplasm of cells. The majority of acetyl-CoA that is transformed into fatty acids originates from carbohydrates through the glycolytic pathway. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP357 CPTAC Assay Portal]
Authors
Kdahlquist , Michiel Adriaens , Alex Pico , Chris Evelo , JT. Saito , Jildau Bouwman , Martijn Van Iersel , Egon Willighagen , Martina Summer-Kutmon , Friederike Ehrhart , Kristina Hanspers , Denise Slenter , Eric Weitz , and Luiz C. M. LadeiraActivity
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Cited In
- Assessing the Contribution of Relative Macrophage Frequencies to Subcutaneous Adipose Tissue (2021).
- Predicting instances of pathway ontology classes for pathway integration (2019).
- Exploring the cellular network of metabolic flexibility in the adipose tissue (2018).
- Long Term Culture of the A549 Cancer Cell Line Promotes Multilamellar Body Formation and Differentiation towards an Alveolar Type II Pneumocyte Phenotype (2016).
- A network biology workflow to study transcriptomics data of the diabetic liver (2014).
- Human Monocytes Exposed to SARS-CoV-2 Display Features of Innate Immune Memory Producing High Levels of CXCL10 upon Restimulation (2023).
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
fatty acid biosynthetic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| 3-L-Hydroxyacyl-CoA | Metabolite | chebi:57318 | |
| Acetyl-ACP | Metabolite | wikidata:Q59811305 | |
| Crotonoyl-ACP | Metabolite | kegg.compound:C04618 | aka (3R)-3-Hydroxybutanoyl-[acyl-carrier protein] |
| Oxaloacetate | Metabolite | chebi:30744 | |
| Fatty acyl CoA | Metabolite | chebi:37554 | |
| Palmitate | Metabolite | chemspider:440215 | |
| Malonyl-ACP | Metabolite | kegg.compound:C01209 | |
| Butyryl-ACP | Metabolite | chebi:3247 | |
| Acetoacetyl-ACP | Metabolite | chebi:2393 | |
| Palmitoyl-ACP | Metabolite | kegg.compound:C16520 | |
| Citrate | Metabolite | chemspider:29081 | |
| pyruvate | Metabolite | chebi:15361 | |
| Long-Chain fatty acid | Metabolite | chebi:15904 | |
| 3-ketoacyl-CoA | Metabolite | chebi:57347 | aka 3-oxo-fatty acyl-CoA(4−) |
| Malonyl-CoA | Metabolite | cas:524-14-1 | Used in small tissue samples as [14C] isotope tracer to improve sensiticity of FASN activity. [https://doi.org/10.1515/bchm3.1986.367.2.905] |
| Acetyl-CoA | Metabolite | chebi:15351 | |
| Acyl-CoA (n+2) | Metabolite | chebi:17984 | |
| FASN | GeneProduct | ncbigene:2194 | |
| ECHS1 | GeneProduct | ncbigene:1892 | |
| ACSL5 | GeneProduct | ncbigene:51703 | |
| PECR | GeneProduct | ncbigene:55825 | |
| ECHDC2 | GeneProduct | ncbigene:55268 | |
| ACACA | GeneProduct | ncbigene:31 | |
| ECHDC1 | GeneProduct | ncbigene:55862 | |
| ACSL4 | GeneProduct | ncbigene:2182 | |
| SCD | GeneProduct | ncbigene:6319 | |
| ACAS2 | GeneProduct | ncbigene:55902 | |
| ECHDC3 | GeneProduct | ncbigene:79746 | |
| ACLY | GeneProduct | ncbigene:47 | |
| ACSL3 | GeneProduct | ncbigene:2181 | |
| HADHSC | GeneProduct | ncbigene:3033 | |
| ACACB | GeneProduct | ncbigene:32 | |
| ACSL1 | GeneProduct | ncbigene:2180 | |
| PC | GeneProduct | ncbigene:5091 | |
| ACAA2 | GeneProduct | ncbigene:10449 | |
| MECR | GeneProduct | ncbigene:51102 | |
| DECR1 | GeneProduct | ncbigene:1666 | |
| ACSL6 | GeneProduct | ncbigene:23305 | |
| ECH1 | GeneProduct | ncbigene:1891 | |
| Acetyl-synthase | Protein | ensembl:ENSG00000131069 |
References
- Fatty-acid biosynthesis in man, a pathway of minor importance. Purification, optimal assay conditions, and organ distribution of fatty-acid synthase. Weiss L, Hoffmann GE, Schreiber R, Andres H, Fuchs E, Körber E, et al. Biol Chem Hoppe Seyler. 1986 Sep;367(9):905–12. PubMed Europe PMC Scholia