Retinoblastoma gene in cancer (WP2446)

Homo sapiens

Authors

Jack Youngren , Martina Summer-Kutmon , Egon Willighagen , Chris Evelo , Kristina Hanspers , Linda Rieswijk , Alex Pico , Friederike Ehrhart , Finterly Hu , and Eric Weitz

Activity

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Cited In

• Understanding signaling and metabolic paths using semantified and harmonized information about biological interactions (2022).
• DNA methylation of ARHGAP30 is negatively associated with ARHGAP30 expression in lung adenocarcinoma, which reduces tumor immunity and is detrimental to patient survival (2021).
• Identification of CCNB2 as A Potential Non-Invasive Breast Cancer Biomarker in Peripheral Blood Mononuclear Cells Using The Systems Biology Approach (2021).
• Systems Biomedicine of Primary and Metastatic Colorectal Cancer Reveals Potential Therapeutic Targets (2021).
• A novel single-cell based method for breast cancer prognosis (2020).
• Proteostasis regulators modulate proteasomal activity and gene expression to attenuate multiple phenotypes in Fabry disease (2020).
• The double dealing of cyclin D1 (2020).
• Characteristic miRNA expression signature and random forest survival analysis identify potential cancer-driving miRNAs in a broad range of head and neck squamous cell carcinoma subtypes (2018).
• Long Term Culture of the A549 Cancer Cell Line Promotes Multilamellar Body Formation and Differentiation towards an Alveolar Type II Pneumocyte Phenotype (2016).
• Identification of the effects of COVID-19 on patients with pulmonary fibrosis and lung cancer: a bioinformatics analysis and literature review (2022).
• Investigation of the relationship between COVID-19 and pancreatic cancer using bioinformatics and systems biology approaches (2024).

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Organisms

Homo sapiens

Communities

CPTAC Diseases PancCanNet

Annotations

Pathway Ontology

disease pathway cancer pathway

Disease Ontology

cancer

References

1. Abrogation of retinoblastoma protein function by c-Abl through tyrosine kinase-dependent and -independent mechanisms. Welch PJ, Wang JY. Mol Cell Biol. 1995 Oct;15(10):5542–51. PubMed Europe PMC Scholia
2. A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle. Welch PJ, Wang JY. Cell. 1993 Nov 19;75(4):779–90. PubMed Europe PMC Scholia
3. Leukoencephalopathy: the frontier between what is reversible and what is persistent. Domínguez R, Famulari A, Vila J. Rev Neurol. 1997 Dec;25(148):2074. PubMed Europe PMC Scholia
4. An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant. Ji P, Jiang H, Rekhtman K, Bloom J, Ichetovkin M, Pagano M, et al. Mol Cell. 2004 Oct 8;16(1):47–58. PubMed Europe PMC Scholia
5. MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators. Gabriely G, Wurdinger T, Kesari S, Esau CC, Burchard J, Linsley PS, et al. Mol Cell Biol. 2008 Sep;28(17):5369–80. PubMed Europe PMC Scholia
6. MicroRNA 29b functions in acute myeloid leukemia. Garzon R, Heaphy CEA, Havelange V, Fabbri M, Volinia S, Tsao T, et al. Blood. 2009 Dec 17;114(26):5331–41. PubMed Europe PMC Scholia
7. MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2). Valeri N, Gasparini P, Braconi C, Paone A, Lovat F, Fabbri M, et al. Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21098–103. PubMed Europe PMC Scholia