Toll-like receptor signaling (WP75)

Homo sapiens

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Toll-like receptors (TLRs) are a critical part of the innate immune response, and are expressed on macrophages and dendritic cells. TLRs are pattern-recognition receptors, and recognize molecules derived from microbes. Once activated, TLRs result in activation of innate immunity by inducing production of proinflammatory cytokines and upregulation of costimulatory molecules TLR signaling pathways are separated into two groups: a MyD88-dependent pathway that leads to the production of proinflammatory cytokines with quick activation of NFkB and MAPK; and a MyD88-independent pathway associated with the induction of IFN-beta and IFN-inducible genes, and maturation of dendritic cells with slow activation of NFkB and MAPK. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP75 CPTAC Assay Portal].

Authors

Judith M. Boer , Thomas Kelder , Alex Pico , Kristina Hanspers , Zezhong Li , Egon Willighagen , Martina Summer-Kutmon , Jonathan Mélius , Denise Slenter , Eric Weitz , and Finterly Hu

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Cell Type Ontology

dendritic cell macrophage mast cell

Pathway Ontology

signaling pathway pertinent to immunity Toll-like receptor signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Imidazoquinolin Metabolite chemspider:14697812
Zymosan (Yeast) Metabolite chebi:37671
LPS (Gram negative) Metabolite chebi:52603
Peptidoglycan(Gram positive) Metabolite chebi:8005
Lipoprotein particle Metabolite chebi:6495
Lipoarabinomannans(Mycobacteria) Metabolite chebi:59524
LY96 GeneProduct ncbigene:23643 Original kegg element: gene;71;hsa:23643
MAPK12 GeneProduct ncbigene:6300 Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
IRAK1 GeneProduct ncbigene:3654 Original kegg element: gene;4;hsa:3654
CD80 GeneProduct ncbigene:941 Original kegg element: gene;69;hsa:941
IFNA10 GeneProduct ncbigene:3446 Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
TLR1 GeneProduct ncbigene:7096 Original kegg element: gene;75;hsa:7096
TIRAP GeneProduct ncbigene:114609 Original kegg element: gene;83;hsa:114609
TLR9 GeneProduct ncbigene:54106 Original kegg element: gene;78;hsa:54106
STAT1 GeneProduct ncbigene:6772 Original kegg element: gene;62;hsa:6772
IRAK4 GeneProduct ncbigene:51135 Original kegg element: gene;5;hsa:51135
TLR5 GeneProduct ncbigene:7100 Original kegg element: gene;72;hsa:7100
NFKB1 GeneProduct ncbigene:4790 Original kegg element: gene;14;hsa:4790
TICAM1 GeneProduct ncbigene:148022 Original kegg element: gene;82;hsa:148022
IFNA8 GeneProduct ncbigene:3445 Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
MAPK14 GeneProduct ncbigene:1432 Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
TRAF6 GeneProduct ncbigene:7189 Original kegg element: gene;53;hsa:7189
AKT2 GeneProduct ncbigene:208 Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
CCL5 GeneProduct ncbigene:6352 Original kegg element: gene;58;hsa:6352
TOLLIP GeneProduct ncbigene:54472 Original kegg element: gene;81;hsa:54472
IL12B GeneProduct ncbigene:3593 Original kegg element: gene;45;hsa:3592 hsa:3593
IFNA16 GeneProduct ncbigene:3449 Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
TRAF3 GeneProduct ncbigene:7187 Original kegg element: gene;16;hsa:7187
TLR6 GeneProduct ncbigene:10333 Original kegg element: gene;76;hsa:10333
MAPK10 GeneProduct ncbigene:5602 Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
IFNA2 GeneProduct ncbigene:3440 Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
CHUK GeneProduct ncbigene:1147 Original kegg element: gene;2;hsa:1147
TBK1 GeneProduct ncbigene:29110 Original kegg element: gene;52;hsa:29110
AKT3 GeneProduct ncbigene:10000 Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
TAB2 GeneProduct ncbigene:23118 Original kegg element: gene;61;hsa:23118
IL12A GeneProduct ncbigene:3592 Original kegg element: gene;45;hsa:3592 hsa:3593
IFNA7 GeneProduct ncbigene:3444 Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA21 GeneProduct ncbigene:3452 Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
TRAF6 GeneProduct ncbigene:7189 Original kegg element: gene;3;hsa:7189
TNF GeneProduct ncbigene:7124 Original kegg element: gene;66;hsa:7124
CD40 GeneProduct ncbigene:958 Original kegg element: gene;29;hsa:958
IFNA17 GeneProduct ncbigene:3451 Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
CASP8 GeneProduct ncbigene:841 Original kegg element: gene;87;hsa:841
TIRAP GeneProduct ncbigene:114609 Original kegg element: gene;46;hsa:114609
SPP1 GeneProduct ncbigene:6696 Original kegg element: gene;15;hsa:6696
CCL3 GeneProduct ncbigene:6348 Original kegg element: gene;44;hsa:6348
TLR2 GeneProduct ncbigene:7097 Original kegg element: gene;70;hsa:7097
CXCL10 GeneProduct ncbigene:3627 Original kegg element: gene;25;hsa:3627
TLR4 GeneProduct ncbigene:7099 Original kegg element: gene;79;hsa:7099
IFNA14 GeneProduct ncbigene:3448 Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
TLR7 GeneProduct ncbigene:51284 Original kegg element: gene;39;hsa:51284 hsa:51311
IFNA4 GeneProduct ncbigene:3441 Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IKBKE GeneProduct ncbigene:9641 Original kegg element: gene;54;hsa:9641
IFNA1 GeneProduct ncbigene:3439 Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IRF7 GeneProduct ncbigene:3665 Original kegg element: gene;20;hsa:3665
MAP2K4 GeneProduct ncbigene:6416 Original kegg element: gene;63;hsa:5609 hsa:6416
IL1B GeneProduct ncbigene:3553 Original kegg element: gene;51;hsa:3553
MYD88 GeneProduct ncbigene:4615 Original kegg element: gene;6;hsa:4615
IRAK1 GeneProduct ncbigene:3654 Original kegg element: gene;41;hsa:3654
TLR8 GeneProduct ncbigene:51311 Original kegg element: gene;39;hsa:51284 hsa:51311
MAP3K7 GeneProduct ncbigene:6885 Original kegg element: gene;37;hsa:6885
TICAM2 GeneProduct ncbigene:353376 Original kegg element: gene;80;hsa:353376
IRF3 GeneProduct ncbigene:3661 Original kegg element: gene;67;hsa:3661
IL6 GeneProduct ncbigene:3569 Original kegg element: gene;57;hsa:3569
CD86 GeneProduct ncbigene:942 Original kegg element: gene;28;hsa:942
MAPK3 GeneProduct ncbigene:5595 Original kegg element: gene;11;hsa:5594 hsa:5595
IRAK4 GeneProduct ncbigene:51135 Original kegg element: gene;86;hsa:51135
MAPK13 GeneProduct ncbigene:5603 Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
IFNA13 GeneProduct ncbigene:3447 Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
CD14 GeneProduct ncbigene:929 Original kegg element: gene;84;hsa:929
IFNB1 GeneProduct ncbigene:3456 Original kegg element: gene;1;hsa:3456
IFNAR1 GeneProduct ncbigene:3454 Original kegg element: gene;49;hsa:3454 hsa:3455
MYD88 GeneProduct ncbigene:4615 Original kegg element: gene;8;hsa:4615
MAPK8 GeneProduct ncbigene:5599 Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
RIPK1 GeneProduct ncbigene:8737 Original kegg element: gene;17;hsa:8737
LBP GeneProduct ncbigene:3929 Original kegg element: gene;77;hsa:3929
MYD88 GeneProduct ncbigene:4615 Original kegg element: gene;7;hsa:4615
IRF5 GeneProduct ncbigene:3663 Original kegg element: gene;21;hsa:3663
TAB1 GeneProduct ncbigene:10454 Original kegg element: gene;59;hsa:10454
PI3K GeneProduct wikipathways:WP5472
IL8 GeneProduct ncbigene:3576 Original kegg element: gene;43;hsa:3576
MAPK1 GeneProduct ncbigene:5594 Original kegg element: gene;11;hsa:5594 hsa:5595
MAP2K1 GeneProduct ncbigene:5604 Original kegg element: gene;12;hsa:5604 hsa:5605
FADD GeneProduct ncbigene:8772 Original kegg element: gene;56;hsa:8772
MAP2K2 GeneProduct ncbigene:5605 Original kegg element: gene;12;hsa:5604 hsa:5605
IFNAR2 GeneProduct ncbigene:3455 Original kegg element: gene;49;hsa:3454 hsa:3455
TRAF6 GeneProduct ncbigene:7189 Original kegg element: gene;9;hsa:7189
IFNA5 GeneProduct ncbigene:3442 Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
MYD88 GeneProduct ncbigene:4615 Original kegg element: gene;47;hsa:4615
MAP3K8 GeneProduct ncbigene:1326 Original kegg element: gene;13;hsa:1326
RAC1 GeneProduct ncbigene:5879 Original kegg element: gene;48;hsa:5879
TLR2 GeneProduct ncbigene:7097 Original kegg element: gene;74;hsa:7097
MAP2K7 GeneProduct ncbigene:5609 Original kegg element: gene;63;hsa:5609 hsa:6416
CXCL9 GeneProduct ncbigene:4283 Original kegg element: gene;24;hsa:4283
TLR3 GeneProduct ncbigene:7098 Original kegg element: gene;73;hsa:7098
IFNA6 GeneProduct ncbigene:3443 Original kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
AKT1 GeneProduct ncbigene:207 Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
MAPK11 GeneProduct ncbigene:5600 Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
CCL4 GeneProduct ncbigene:6351 Original kegg element: gene;38;hsa:6351
FOS GeneProduct ncbigene:2353 Original kegg element: gene;35;hsa:2353 hsa:3725
CXCL11 GeneProduct ncbigene:6373 Original kegg element: gene;23;hsa:6373
MAPK9 GeneProduct ncbigene:5601 Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
TAB3 GeneProduct ncbigene:257397 Original kegg element: gene;61;hsa:23118
IKBKG GeneProduct ensembl:ENSG00000269335
IKBKB GeneProduct ensembl:ENSG00000104365
CHUK GeneProduct ensembl:ENSG00000213341
NFKB1 GeneProduct ncbigene:4790
RELA GeneProduct ensembl:ENSG00000173039
NFKBIA GeneProduct ensembl:ENSG00000100906
NFKBIB GeneProduct ensembl:ENSG00000104825
JUN GeneProduct ncbigene:3725
MAP2K3 GeneProduct ncbigene:5606
MAP2K6 GeneProduct ncbigene:5608

References

  1. KEGG Pathway: hsa04620
  2. TLR signaling pathways. Takeda K, Akira S. Semin Immunol. 2004 Feb;16(1):3–9. PubMed Europe PMC Scholia
  3. Toll-like receptor and RIG-I-like receptor signaling. Kawai T, Akira S. Ann N Y Acad Sci. 2008 Nov;1143:1–20. PubMed Europe PMC Scholia