DNA damage response (only ATM dependent) (WP710)
Homo sapiens
This is one of two pathways that deal with DNA damage. It has two central gene products (ATM and TP53) which are connected with the [[Pathway:WP707|other DNA damage response pathway]]. In this pathway there is only one source of DNA damage induction, since most DNA damage induction sources and their involvement are mentioned in the [[Pathway:WP707|first DNA damage response pathway]]. If it is not mentioned differently, the processes take place in the cell cytoplasm. The purpose of this pathway is to report more gene products and cell condition changes through the DNA damage response pathway and at the same time keep them clearly arranged. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP710 CPTAC Assay Portal]
Authors
Jonas Hummel , Alex Pico , Martina Summer-Kutmon , Jildau Bouwman , Martijn Van Iersel , Allan Kuchinsky , Christine Chichester , Zahra Roudbari , Ryan Miller , Asios Olia , Kristina Hanspers , Friederike Ehrhart , Lauren J. Dupuis , Finterly Hu , Eric Weitz , and Egon WillighagenActivity
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Cited In
- Biological and clinical features of triple negative Invasive Lobular Carcinomas of the breast. Clinical outcome and actionable molecular alterations☆ (2021).
- MicroRNA expression profiling of Xp11 renal cell carcinoma (2017).
- GediNET for discovering gene associations across diseases using knowledge based machine learning approach (2022).
- Shared mechanisms and crosstalk of COVID-19 and osteoporosis via vitamin D (2022).
- A patient-based iPSC-derived hepatocyte model of alcohol-associated cirrhosis reveals bioenergetic insights into disease pathogenesis (2024).
- MicroRNAs as potential biomarkers for doxorubicin-induced cardiotoxicity.
- A Practical Strategy for Exploring the Pharmacological Mechanism of Luteolin Against COVID-19/Asthma Comorbidity: Findings of System Pharmacology and Bioinformatics Analysis (2024).
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Organisms
Homo sapiensCommunities
CPTAC PancCanNetAnnotations
Pathway Ontology
p53-dependent G1/S DNA damage checkpoint pathway p53 signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| WNT7A | GeneProduct | ncbigene:7476 | |
| AKT1 | GeneProduct | hgnc.symbol:AKT1 | |
| BAK1 | GeneProduct | ensembl:ENSG00000030110 | |
| PIK3R3 | GeneProduct | ncbigene:8503 | |
| JUN | GeneProduct | ncbigene:3725 | |
| PLAU | GeneProduct | ncbigene:5328 | |
| ABL1 | GeneProduct | ensembl:ENSG00000097007 | |
| IRS1 | GeneProduct | ensembl:ENSG00000169047 | |
| MYC | GeneProduct | ncbigene:4609 | |
| RAC1 | GeneProduct | ncbigene:5879 | |
| CCNG2 | GeneProduct | ensembl:ENSG00000138764 | |
| RAC1 | GeneProduct | ensembl:ENSG00000136238 | |
| PIK3C2G | GeneProduct | ncbigene:5288 | |
| AKT2 | GeneProduct | hgnc.symbol:AKT2 | |
| ATM | GeneProduct | ensembl:ENSG00000149311 | |
| FOXO3 | GeneProduct | ensembl:ENSG00000118689 | |
| BCL6 | GeneProduct | ensembl:ENSG00000113916 | |
| CDC42 | GeneProduct | ensembl:ENSG00000070831 | |
| AKT3 | GeneProduct | hgnc.symbol:AKT3 | |
| CDKN1B | GeneProduct | ensembl:ENSG00000111276 | |
| NRAS | GeneProduct | ncbigene:4893 | |
| PIK3C3 | GeneProduct | ncbigene:5289 | |
| WNT11 | GeneProduct | ncbigene:7481 | |
| PIK3R4 | GeneProduct | ncbigene:30849 | |
| c-Myc | GeneProduct | ncbigene:4609 | |
| PIK3CA | GeneProduct | ncbigene:5290 | |
| DVL3 | GeneProduct | ncbigene:1857 | |
| BIK | GeneProduct | ensembl:ENSG00000100290 | |
| AXIN1 | GeneProduct | ncbigene:8312 | |
| MAPK2 | GeneProduct | ncbigene:5594 | |
| WNT16 | GeneProduct | ncbigene:51384 | |
| PIK3CD | GeneProduct | ncbigene:5293 | |
| BCL2 | GeneProduct | ensembl:ENSG00000171791 | |
| CAT | GeneProduct | ensembl:ENSG00000121691 | |
| BAX | GeneProduct | ensembl:ENSG00000087088 | |
| PEPCK | GeneProduct | ncbigene:5106 | |
| PIK3C2A | GeneProduct | ncbigene:5286 | |
| SMAD3 | GeneProduct | ensembl:ENSG00000166949 | |
| MAPK10 | GeneProduct | ncbigene:5602 | |
| CCND1 | GeneProduct | ncbigene:595 | |
| SOD2 | GeneProduct | ensembl:ENSG00000112096 | |
| ERBB2 | GeneProduct | ensembl:ENSG00000141736 | |
| BCL2L11 | GeneProduct | ensembl:ENSG00000153094 | |
| TGFB | GeneProduct | ncbigene:7040 | |
| PIK3CG | GeneProduct | ncbigene:5294 | |
| NFKB1 | GeneProduct | hgnc.symbol:NFKB1 | |
| WNT7B | GeneProduct | ncbigene:7477 | |
| RAC2 | GeneProduct | ensembl:ENSG00000128340 | |
| MAPK9 | GeneProduct | ncbigene:5601 | |
| MAP3K4 | GeneProduct | ensembl:ENSG00000085511 | |
| WNT2 | GeneProduct | ncbigene:7472 | |
| PDK1 | GeneProduct | ensembl:ENSG00000152256 | |
| WNT5B | GeneProduct | ncbigene:81029 | |
| MDM2 | GeneProduct | ensembl:ENSG00000135679 | |
| APC | GeneProduct | ncbigene:324 | |
| MAP3K1 | GeneProduct | ensembl:ENSG00000095015 | |
| PPP2R5C | GeneProduct | ncbigene:5527 | |
| CCND3 | GeneProduct | ncbigene:896 | |
| HRAS | GeneProduct | ncbigene:3265 | |
| FASLG | GeneProduct | ensembl:ENSG00000117560 | |
| GRB2 | GeneProduct | ensembl:ENSG00000177885 | |
| KRAS | GeneProduct | ncbigene:3845 | |
| PIK3R1 | GeneProduct | ncbigene:5295 | |
| SHC1 | GeneProduct | ensembl:ENSG00000160691 | |
| WNT5A | GeneProduct | ncbigene:7474 | |
| WNT10A | GeneProduct | ncbigene:80326 | |
| BBC3 | GeneProduct | hgnc.symbol:BBC3 | |
| PIK3CB | GeneProduct | ncbigene:5291 | |
| TCF-4 | GeneProduct | ncbigene:6934 | |
| TCF-1 | GeneProduct | ncbigene:6932 | |
| PMAIP1 | GeneProduct | ensembl:ENSG00000141682 | |
| BAD | GeneProduct | ensembl:ENSG00000002330 | |
| TCF-3 | GeneProduct | ncbigene:83439 | |
| CCND2 | GeneProduct | ncbigene:894 | |
| FRAT1 | GeneProduct | ncbigene:10023 | |
| WNT6 | GeneProduct | ncbigene:7475 | |
| CTNNB1 | GeneProduct | ncbigene:1499 | |
| PIK3R2 | GeneProduct | ncbigene:5296 | |
| LDLR | GeneProduct | ncbigene:3949 | |
| DVL1 | GeneProduct | ncbigene:1855 | |
| SOS1 | GeneProduct | ensembl:ENSG00000115904 | |
| DVL2 | GeneProduct | ncbigene:1856 | |
| LEF1 | GeneProduct | ncbigene:51176 | |
| WNT3 | GeneProduct | ncbigene:7473 | |
| RAC3 | GeneProduct | hgnc.symbol:RAC3 | |
| TP73 | GeneProduct | ensembl:ENSG00000078900 | |
| PPP2R5E | GeneProduct | ncbigene:5529 | |
| WNT1 | GeneProduct | ncbigene:7471 | |
| SOS2 | GeneProduct | ensembl:ENSG00000100485 | |
| MAP3K7 | GeneProduct | ensembl:ENSG00000135341 | |
| FOSL1 | GeneProduct | ncbigene:8061 | |
| NFKB2 | GeneProduct | hgnc.symbol:NFKB2 | |
| WNT2B | GeneProduct | ncbigene:7482 | |
| MAPK8 | GeneProduct | ensembl:ENSG00000107643 | |
| HMGB1 | GeneProduct | ensembl:ENSG00000189403 | |
| WNT4 | GeneProduct | ncbigene:54361 | |
| WNT3A | GeneProduct | ncbigene:89780 | |
| CDKN1A | GeneProduct | ensembl:ENSG00000124762 | |
| GSK3B | GeneProduct | ncbigene:2932 | MOUSE:KG38 MOUSE |
| SCP2 | GeneProduct | ensembl:ENSG00000116171 | |
| RHOA | GeneProduct | ncbigene:387 | |
| WNT10B | GeneProduct | ncbigene:7480 | |
| PTEN | GeneProduct | ensembl:ENSG00000171862 | |
| PIK3C2B | GeneProduct | ncbigene:5287 | |
| MAPK9 | GeneProduct | ensembl:ENSG00000050748 | |
| G6PC | GeneProduct | ensembl:ENSG00000131482 | |
| SMAD4 | GeneProduct | ensembl:ENSG00000141646 | |
| CDKN2A | GeneProduct | hgnc.symbol:CDKN2A | |
| PIK3R5 | GeneProduct | ncbigene:23533 | |
| TGFB1 | GeneProduct | ensembl:ENSG00000105329 | |
| TP53 | GeneProduct | ensembl:ENSG00000141510 | |
| MLKL | GeneProduct | ensembl:ENSG00000168404 | |
| INSR | GeneProduct | ensembl:ENSG00000171105 | |
| RBL2 | GeneProduct | ensembl:ENSG00000103479 | |
| APC | GeneProduct | ensembl:ENSG00000134982 |
References
- The role of BH3-only proteins in the immune system. Strasser A. Nat Rev Immunol. 2005 Mar;5(3):189–200. PubMed Europe PMC Scholia
- Beta-catenin (CTNNB1) promotes preovulatory follicular development but represses LH-mediated ovulation and luteinization. Fan HY, O’Connor A, Shitanaka M, Shimada M, Liu Z, Richards JS. Mol Endocrinol. 2010 Aug;24(8):1529–42. PubMed Europe PMC Scholia