Calcium regulation in cardiac cells (WP536)

Homo sapiens

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Calcium is a common signaling molecule. Once it enters the cytoplasm, it exerts allosteric regulatory effects on many enzymes and proteins. Calcium can act in signal transduction after influx resulting from activation of ion channels or as a second messenger caused by indirect signal transduction pathways such as G protein-coupled receptors. Movement of calcium ions from the extracellular matrix to the cytoplasm alters membrane depolarization. This is seen in the heart, during the plateau phase of ventricular contraction. In this example, calcium acts to maintain depolarization of the heart. Source: [[wikipedia:Calcium_signaling|Wikipedia]] Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP536 CPTAC Assay Portal]

Authors

Nathan Salomonis , Susan Coort , Thomas Kelder , Joanna Fong , Nathalie Cotte , AMC Human Genetics , Jildau Bouwman , Kristina Hanspers , Alex Pico , Martijn Van Iersel , Christine Chichester , Tyler Peryea , Denise Slenter , Marvin Martens , Friederike Ehrhart , Egon Willighagen , and Eric Weitz

Activity

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Disease Ontology

cardiovascular system disease

Cell Type Ontology

cardiac muscle cell

Pathway Ontology

calcium/calcium-mediated signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
ATP Metabolite cas:1927-31-7
Epinephrine Metabolite hmdb:HMDB0000068
Na+ Metabolite hmdb:HMDB0000588
Acetylcholine Metabolite cas:51-84-3
Pi Metabolite hmdb:HMDB0001429
IP4 Metabolite chebi:16783
IP3 Metabolite chemspider:388562
ADP Metabolite cas:58-64-0
K+ Metabolite hmdb:HMDB0000586
Ca2+ Metabolite hmdb:HMDB0000464
cAMP Metabolite pubchem.compound:6076
PIP2 Metabolite hmdb:HMDB0010032
ADP Metabolite hmdb:HMDB0001341
Ca2+ Metabolite chebi:29108
CACNB1 GeneProduct ncbigene:782
STIM2 GeneProduct ensembl:ENSG00000109689
CALM1 GeneProduct ncbigene:801
CAMK2G GeneProduct ncbigene:818
RYR2 GeneProduct ncbigene:6262
RGS6 GeneProduct ncbigene:9628
ADCY4 GeneProduct ncbigene:196883 There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
GNG2 GeneProduct ncbigene:54331
ADCY1 GeneProduct ncbigene:107 CYA1 HUMAN
CAMK2A GeneProduct ncbigene:815
PRKCB1 GeneProduct ncbigene:5579
CACNA1E GeneProduct ncbigene:777
GNG13 GeneProduct ncbigene:51764
RGS1 GeneProduct ncbigene:5996
ATP2B1 GeneProduct ncbigene:490
PRKACA GeneProduct ncbigene:5566
GNAI2 GeneProduct ncbigene:2771
ATP2A3 GeneProduct ncbigene:489
ATP2B3 GeneProduct ncbigene:492
GJA5 GeneProduct ncbigene:2702
PLCB3 GeneProduct ncbigene:5331
ADRA1A GeneProduct ncbigene:148
GNB4 GeneProduct ncbigene:59345
PLN GeneProduct ncbigene:5350
RGS20 GeneProduct ncbigene:8601
GJA10 GeneProduct ncbigene:81025
CALM2 GeneProduct ncbigene:805
PRKACB GeneProduct ncbigene:5567
RYR1 GeneProduct ncbigene:6261
CAMK4 GeneProduct ncbigene:814
ADCY5 GeneProduct ncbigene:111 There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
PKIB GeneProduct ncbigene:5570
ARRB2 GeneProduct ncbigene:409
RGS10 GeneProduct ncbigene:6001
ADRA1D GeneProduct ncbigene:146
ADRB1 GeneProduct ncbigene:153
RGS14 GeneProduct ncbigene:10636
CACNA1S GeneProduct ncbigene:779
CHRM4 GeneProduct ncbigene:1132
CHRM2 GeneProduct ncbigene:1129
CACNA1C GeneProduct ncbigene:775
GJA7 GeneProduct ncbigene:10052
KCNB1 GeneProduct ncbigene:3745
ADCY2 GeneProduct ncbigene:108 There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
GJA1 GeneProduct ncbigene:2697
ITPR2 GeneProduct ncbigene:3709
PRKAR1B GeneProduct ncbigene:5575
CACNA1D GeneProduct ncbigene:776
CAMK2D GeneProduct ncbigene:817
GNB3 GeneProduct ncbigene:2784
CACNA1A GeneProduct ncbigene:773
KCNJ3 GeneProduct ncbigene:3760
RGS5 GeneProduct ncbigene:8490
YWHAB GeneProduct ncbigene:7529
GNB5 GeneProduct ncbigene:10681
KCNJ5 GeneProduct ncbigene:3762
YWHAZ GeneProduct ncbigene:7534 PMID: 9861170 PMID: 1317796
YWHAH GeneProduct ncbigene:7533
GJA3 GeneProduct ncbigene:2700
ITPR1 GeneProduct ncbigene:3708
ATP2B2 GeneProduct ncbigene:491
GJB3 GeneProduct ncbigene:2707
GJB4 GeneProduct ncbigene:127534
SFN GeneProduct ncbigene:2810
PRKD1 GeneProduct ncbigene:5587 KPCM HUMAN
GNG12 GeneProduct ncbigene:55970
GNAQ GeneProduct ncbigene:2776
GNG11 GeneProduct ncbigene:2791
PRKCD GeneProduct ncbigene:5580
GNG7 GeneProduct ncbigene:2788
GJB6 GeneProduct ncbigene:10804
GNAI3 GeneProduct ncbigene:2773
PRKCE GeneProduct ncbigene:5581 This EST is listed on the Affymetrix Murine6500 chip. The SwissProt entry name is KPCE MOUSE.
RGS18 GeneProduct ncbigene:64407
RGS7 GeneProduct ncbigene:6000
GRK5 GeneProduct ncbigene:2869
GNG8 GeneProduct ncbigene:94235
PKIA GeneProduct ncbigene:5569
RYR3 GeneProduct ncbigene:6263
ITPR3 GeneProduct ncbigene:3710
ADCY8 GeneProduct ncbigene:114
CHRM1 GeneProduct ncbigene:1128
RGS19 GeneProduct ncbigene:10287
ADRA1B GeneProduct ncbigene:147
CALM3 GeneProduct ncbigene:808
FKBP1A GeneProduct ncbigene:2280
GJB1 GeneProduct ncbigene:2705
GJA8 GeneProduct ncbigene:2703
RGS17 GeneProduct ncbigene:26575
Calsequestrin GeneProduct ncbigene:844
ADCY3 GeneProduct ncbigene:109
YWHAE GeneProduct ncbigene:7531
ANXA6 GeneProduct ncbigene:309
GNA11 GeneProduct ncbigene:2767
GNG5 GeneProduct ncbigene:2787
ADCY9 GeneProduct ncbigene:115
RGS16 GeneProduct ncbigene:6004
SLC8A1 GeneProduct ncbigene:6546
YWHAQ GeneProduct ncbigene:10971
ADCY7 GeneProduct ncbigene:113
GNAZ GeneProduct ncbigene:2781
ADRB3 GeneProduct ncbigene:155
GJB5 GeneProduct ncbigene:2709
Calreticulin GeneProduct ncbigene:811
RGS11 GeneProduct ncbigene:8786
CASQ1 GeneProduct ncbigene:844
GNGT1 GeneProduct ncbigene:2792
PRKCZ GeneProduct ncbigene:5590
PRKAR1A GeneProduct ncbigene:5573 KAP0 HUMAN
GNB2 GeneProduct ncbigene:2783
PKIG GeneProduct ncbigene:11142
RGS4 GeneProduct ncbigene:5999
PRKCH GeneProduct ncbigene:5583
PRKAR2B GeneProduct ncbigene:5577
PRKCQ GeneProduct ncbigene:5588
GNG3 GeneProduct ncbigene:2785
PRKCA GeneProduct ncbigene:5578
GJA12 GeneProduct ncbigene:57165
GNB1 GeneProduct ncbigene:2782
CASQ2 GeneProduct ncbigene:845
GNAO1 GeneProduct ncbigene:2775
SLC8A3 GeneProduct ncbigene:6547
Phospholamban GeneProduct ensembl:ENSG00000198523
ATP2A2 GeneProduct ncbigene:488
RGS2 GeneProduct ncbigene:5997
ARRB1 GeneProduct ncbigene:408
GNAS GeneProduct ncbigene:2778
GJB2 GeneProduct ncbigene:2706
CACNA1B GeneProduct ncbigene:774
GNAI1 GeneProduct ncbigene:2770
CHRM3 GeneProduct ncbigene:1131
CALR GeneProduct ncbigene:811
RGS9 GeneProduct ncbigene:8787
CHRM5 GeneProduct ncbigene:1133
CAMK2B GeneProduct ncbigene:816
GJA4 GeneProduct ncbigene:2701
GNG4 GeneProduct ncbigene:2786
YWHAG GeneProduct ncbigene:7532
CAMK1 GeneProduct ncbigene:8536
CACNB3 GeneProduct ncbigene:784
PRKCG GeneProduct ncbigene:5582
ADCY6 GeneProduct ncbigene:112
GRK4 GeneProduct ncbigene:2868
PRKAR2A GeneProduct ncbigene:5576
ADRB2 GeneProduct ncbigene:154
RGS3 GeneProduct ncbigene:5998
CX36 GeneProduct ncbigene:57369
GRK6 GeneProduct ncbigene:2870
ATP1A4 GeneProduct ncbigene:480
ATP1B1 GeneProduct ncbigene:481
FXYD2 GeneProduct ncbigene:486
ATP1B2 GeneProduct ncbigene:482
ATP1B3 GeneProduct ncbigene:483
ORAI1 GeneProduct ensembl:ENSG00000276045

References

  1. Calcium and the heart: a question of life and death. Marks AR. J Clin Invest. 2003 Mar;111(5):597–600. PubMed Europe PMC Scholia