Cholesterol metabolism with Bloch and Kandutsch-Russell pathways (WP4718)
Homo sapiens
New PW, homology converted
Authors
Denise Slenter , Eric Weitz , and Kristina HanspersActivity
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Organisms
Homo sapiensCommunities
Lipids and LIPID MAPSAnnotations
Pathway Ontology
cholesterol biosynthetic pathway cholesterol metabolic pathway lipid signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| 9Z-palmitoleic acid | Metabolite | pubchem.compound:445638 | Assuming this is omega 7-type |
| 7alpha-hydroxycholesterol | Metabolite | lipidmaps:LMST01010013 | |
| Acetyl-CoA | Metabolite | lipidmaps:LMFA07050281 | |
| CE(16:1) | Metabolite | wikidata:Q412366 | Assuming this is omega-7 type |
| Acetoacetyl-CoA | Metabolite | lipidmaps:LMFA07050030 | |
| HMG-CoA | Metabolite | lipidmaps:LMFA07050116 | |
| Mevalonic acid | Metabolite | lipidmaps:LMFA01050352 | |
| Mevalonate-5-P | Metabolite | lipidmaps:LMFA01050415 | |
| Mevalonate-5-PP | Metabolite | lipidmaps:LMFA01050416 | |
| Isopentenyl-PP | Metabolite | lipidmaps:LMPR01010008 | |
| Dimethylallyl-PP | Metabolite | lipidmaps:LMPR01010001 | |
| Geranyl-PP | Metabolite | lipidmaps:LMPR0102010001 | |
| Farnesyl-PP | Metabolite | lipidmaps:LMPR0103010002 | |
| Squalene | Metabolite | lipidmaps:LMPR0106010002 | |
| Squalene-2,3-epoxide | Metabolite | lipidmaps:LMPR0106010010 | |
| Diepoxy-squalene | Metabolite | lipidmaps:LMPR0106010038 | |
| Lanosterol | Metabolite | lipidmaps:LMST01010017 | |
| 24,25-epoxycholesterol | Metabolite | lipidmaps:LMST01010012 | |
| 24,25-dihydrolanosterol | Metabolite | lipidmaps:LMST01010087 | |
| 32-hydroxylanosterol | Metabolite | lipidmaps:LMST01010124 | |
| 4,4-dimethylcholesta-5,8,24-trienol | Metabolite | lipidmaps:LMST01010149 | |
| 4,4-dimethylcholest-8-enol | Metabolite | lipidmaps:LMST01010225 | |
| 14-demethyl-lanosterol | Metabolite | lipidmaps:LMST01010176 | |
| 4-alpha-methylcholest-8-enol | Metabolite | lipidmaps:LMST01010197 | |
| Zymosterol | Metabolite | lipidmaps:LMST01010066 | |
| 4-alpha-methyl-cholest-8-enone | Metabolite | lipidmaps:LMST01010236 | |
| Zymostenol | Metabolite | lipidmaps:LMST01010096 | |
| Lathosterol | Metabolite | lipidmaps:LMST01010089 | |
| 7-dehdrocholesterol | Metabolite | lipidmaps:LMST01010069 | |
| Cholestadienol | Metabolite | lipidmaps:LMST01010206 | aka 24-dehydrolathosterol |
| 7-dehydodesmosterol | Metabolite | lipidmaps:LMST01010121 | |
| Desmosterol | Metabolite | lipidmaps:LMST01010016 | |
| Cholesterol | Metabolite | lipidmaps:LMST01010001 | |
| 7-oxocholesterol | Metabolite | lipidmaps:LMST01010049 | |
| Cholestenone | Metabolite | lipidmaps:LMST01010015 | |
| 4beta-hydroxycholesterol | Metabolite | lipidmaps:LMST01010014 | |
| 24S-hydroxycholesterol | Metabolite | lipidmaps:LMST01010019 | |
| 25-hydroxycholesterol | Metabolite | lipidmaps:LMST01010018 | |
| 27-hydroxycholesterol | Metabolite | lipidmaps:LMST01010057 | |
| Cholesteryl esters (CE) | Metabolite | chebi:17002 | |
| Acyl-CoA | Metabolite | lipidmaps:LMFA07050000 | |
| PreSqualene | Metabolite | wikidata:Q27088444 | Annotated while assuming this compound is actually presqualene-diphosphate |
| CE(18:1) | Metabolite | wikidata:Q27116670 | Assuming this is omega-7 type |
| Oleic acid | Metabolite | wikidata:Q207688 | Aka C18:1 (omega 9) |
| 4-methyl zymostenol | Metabolite | pubchem.compound:22212495 | |
| FF-MAS | Metabolite | cas:64284-64-6 | aka 14-demethyl-14-dehydrolanosterolC12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/C=C(\C)/C)CC=[C@@]21C SMILES |
| SREBF1 | GeneProduct | ensembl:ENSG00000072310 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000020538 |
| ABCA1 | GeneProduct | ensembl:ENSG00000165029 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015243 |
| CH25H | GeneProduct | ensembl:ENSG00000138135 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 |
| HMGCR | GeneProduct | ensembl:ENSG00000113161 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15357 |
| NR1H3 | GeneProduct | ensembl:ENSG00000025434 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000002108 |
| SOAT1 | GeneProduct | ensembl:ENSG00000057252 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20652 |
| FASN | GeneProduct | ensembl:ENSG00000169710 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000025153 |
| DHCR7 | GeneProduct | ensembl:ENSG00000172893 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13360 |
| SC5D | GeneProduct | ensembl:ENSG00000109929 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:235293 |
| EBP | GeneProduct | ensembl:ENSG00000147155 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13595 |
| NSDHL | GeneProduct | ensembl:ENSG00000147383 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18194 |
| CYP51A1 | GeneProduct | ensembl:ENSG00000001630 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13121 |
| TM7SF2 | GeneProduct | ensembl:ENSG00000149809 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:73166 |
| MSMO1 | GeneProduct | ensembl:ENSG00000052802 | aka Sc4molHomology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 |
| HSD17B7 | GeneProduct | ensembl:ENSG00000132196 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15490 |
| DHCR24 | GeneProduct | ensembl:ENSG00000116133 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74754 |
| CYP46A1 | GeneProduct | ensembl:ENSG00000036530 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13116 |
| CYP27A1 | GeneProduct | ensembl:ENSG00000135929 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:104086 |
| SOAT2 | GeneProduct | ensembl:ENSG00000167780 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:223920 |
| ACAT2 | GeneProduct | ensembl:ENSG00000120437 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:171210 |
| HMGCS1 | GeneProduct | ensembl:ENSG00000112972 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:208715 |
| HMGCS2 | GeneProduct | ensembl:ENSG00000134240 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15360 |
| MVK | GeneProduct | ensembl:ENSG00000110921 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17855 |
| PMVK | GeneProduct | ensembl:ENSG00000163344 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:68603 |
| MVD | GeneProduct | ensembl:ENSG00000167508 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:192156 |
| SQLE | GeneProduct | ensembl:ENSG00000104549 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20775 |
| IDI1 | GeneProduct | ensembl:ENSG00000067064 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:319554 |
| FDFT1 | GeneProduct | ensembl:ENSG00000079459 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14137 |
| GGPS1 | GeneProduct | ensembl:ENSG00000152904 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14593 |
| FDPS | GeneProduct | ensembl:ENSG00000160752 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:110196 |
| LSS | GeneProduct | ensembl:ENSG00000160285 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16987 |
| NR1H2 | GeneProduct | ensembl:ENSG00000131408 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000060601 |
| ABCG1 | GeneProduct | ensembl:ENSG00000160179 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000024030 |
| MYLIP | GeneProduct | ensembl:ENSG00000007944 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000038175 |
| SREBF2 | GeneProduct | ensembl:ENSG00000198911 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000022463 |
| ACSL1 | GeneProduct | ensembl:ENSG00000151726 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000018796 |
| ACSL3 | GeneProduct | ensembl:ENSG00000123983 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032883 |
| ACSL4 | GeneProduct | ensembl:ENSG00000068366 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000031278 |
| ACOT2 | GeneProduct | ensembl:ENSG00000119673 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021226 |
| DHCR24 | Protein | ensembl:ENSG00000116133 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q8VCH6 |
| ELOVL2 | Protein | ensembl:ENSG00000197977 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021364 |
| ELOVL3 | Protein | ensembl:ENSG00000119915 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000038754 |
| ELOVL4 | Protein | ensembl:ENSG00000118402 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032262 |
| ELOVL5 | Protein | ensembl:ENSG00000012660 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032349 |
| FADS1 | Protein | ensembl:ENSG00000149485 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000010663 |
| FADS2 | Protein | ensembl:ENSG00000134824 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000024665 |
| SCD | Protein | ensembl:ENSG00000099194 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000037071 |
| CYP51A1 | Protein | ensembl:ENSG00000001630 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q8K0C4 |
| TM7SF2 | Protein | ensembl:ENSG00000149809 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q71KT5 |
| MSMO1 | Protein | ensembl:ENSG00000052802 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9CRA4 |
| NSDHL | Protein | ensembl:ENSG00000147383 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9R1J0 |
| LBR | Protein | ensembl:ENSG00000143815 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q3U9G9 |
| TM7SF2 | Protein | ensembl:ENSG00000149809 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:73166 |
| HSD17B7 | Protein | ensembl:ENSG00000132196 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15490 |
References
- Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase. Bae SH, Paik YK. Biochem J. 1997 Sep 1;326 ( Pt 2)(Pt 2):609–16. PubMed Europe PMC Scholia
- A mouse macrophage lipidome. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia
- Liver x receptor modulation of gene expression leading to proluteolytic effects in primate luteal cells. Bogan RL, Debarber AE, Hennebold JD. Biol Reprod. 2012 Mar 30;86(3):89. PubMed Europe PMC Scholia
- Steroidal triterpenes of cholesterol synthesis. Ačimovič J, Rozman D. Molecules. 2013 Apr 4;18(4):4002–17. PubMed Europe PMC Scholia
- Steroidal triterpenes of cholesterol synthesis. Ačimovič J, Rozman D. Molecules. 2013 Apr 4;18(4):4002–17. PubMed Europe PMC Scholia