Cholesterol metabolism with Bloch and Kandutsch-Russell pathways (WP4718)
Homo sapiens
This pathway is inspired by the Lipidmaps>Sterol lipids expended pathway display and extended with Scheme 1 from Acimovic et al 2013. Literature suggests that cholesterol synthesis preferentially starts with the Bloch pathway, however there is a shift to the Kandutsch-Russell part via lathosterol (Bae et al, 1997). Dashed lines indicate that multiple steps are involved to create the final product. Several regulatory effects concerning the metabolites of cholesterol have been indicated as well. The content from the Bloch and Kandutsch-Russel pathways have been checked against literature, and differences compared to the original LipidMaps pathway have been coloured turquoise.
For a description of pathway objects, see the WikiPathways Legend.
Authors
Denise Slenter , Eric Weitz , Kristina Hanspers , Egon Willighagen , and Daniela DiglesActivity
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Cited In
- PGF2α induces a pro-labour phenotypical switch in human myometrial cells that can be inhibited with PGF2α receptor antagonists (2023).
- Enhanced therapeutic effects of hypoxia-preconditioned mesenchymal stromal cell-derived extracellular vesicles in renal ischemic injury (2025).
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Organisms
Homo sapiensCommunities
Lipids and LIPID MAPS ONTOX Serious Request 2024 - MetaKidsAnnotations
Pathway Ontology
lipid signaling pathway cholesterol metabolic pathway cholesterol biosynthetic pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| 9Z-palmitoleic acid | Metabolite | pubchem.compound:445638 | Assuming this is omega 7-type |
| 7alpha-hydroxycholesterol | Metabolite | lipidmaps:LMST01010013 | |
| Acetyl-CoA | Metabolite | lipidmaps:LMFA07050281 | |
| CE(16:1) | Metabolite | wikidata:Q412366 | Assuming this is omega-7 type |
| Acetoacetyl-CoA | Metabolite | lipidmaps:LMFA07050030 | |
| HMG-CoA | Metabolite | lipidmaps:LMFA07050116 | |
| Mevalonic acid | Metabolite | lipidmaps:LMFA01050352 | |
| Mevalonate-5-P | Metabolite | lipidmaps:LMFA01050415 | |
| Mevalonate-5-PP | Metabolite | lipidmaps:LMFA01050416 | |
| Isopentenyl-PP | Metabolite | lipidmaps:LMPR01010008 | |
| Dimethylallyl-PP | Metabolite | lipidmaps:LMPR01010001 | |
| Geranyl-PP | Metabolite | lipidmaps:LMPR0102010001 | |
| Farnesyl-PP | Metabolite | lipidmaps:LMPR0103010002 | |
| Squalene | Metabolite | lipidmaps:LMPR0106010002 | |
| Squalene-2,3-epoxide | Metabolite | lipidmaps:LMPR0106010010 | |
| Diepoxy-squalene | Metabolite | lipidmaps:LMPR0106010038 | |
| Lanosterol | Metabolite | lipidmaps:LMST01010017 | |
| 24,25-epoxycholesterol | Metabolite | lipidmaps:LMST01010012 | |
| 24,25-dihydrolanosterol | Metabolite | lipidmaps:LMST01010087 | |
| 32-hydroxylanosterol | Metabolite | lipidmaps:LMST01010124 | |
| 4,4-dimethylcholesta-5,8,24-trienol | Metabolite | lipidmaps:LMST01010149 | |
| 4,4-dimethylcholest-8-enol | Metabolite | lipidmaps:LMST01010225 | |
| 14-demethyl-lanosterol | Metabolite | lipidmaps:LMST01010176 | |
| 4-alpha-methylcholest-8-enol | Metabolite | lipidmaps:LMST01010197 | |
| Zymosterol | Metabolite | lipidmaps:LMST01010066 | |
| 4-alpha-methyl-cholest-8-enone | Metabolite | lipidmaps:LMST01010236 | |
| Zymostenol | Metabolite | lipidmaps:LMST01010096 | |
| Lathosterol | Metabolite | lipidmaps:LMST01010089 | |
| 7-dehdrocholesterol | Metabolite | lipidmaps:LMST01010069 | |
| Cholestadienol | Metabolite | lipidmaps:LMST01010206 | aka 24-dehydrolathosterol |
| 7-dehydodesmosterol | Metabolite | lipidmaps:LMST01010121 | |
| Desmosterol | Metabolite | lipidmaps:LMST01010016 | |
| Cholesterol | Metabolite | lipidmaps:LMST01010001 | |
| 7-oxocholesterol | Metabolite | lipidmaps:LMST01010049 | |
| Cholestenone | Metabolite | lipidmaps:LMST01010015 | |
| 4beta-hydroxycholesterol | Metabolite | lipidmaps:LMST01010014 | |
| 24S-hydroxycholesterol | Metabolite | lipidmaps:LMST01010019 | |
| 25-hydroxycholesterol | Metabolite | lipidmaps:LMST01010018 | |
| 27-hydroxycholesterol | Metabolite | lipidmaps:LMST01010057 | |
| Cholesteryl esters (CE) | Metabolite | chebi:17002 | |
| Acyl-CoA | Metabolite | lipidmaps:LMFA07050000 | |
| PreSqualene | Metabolite | wikidata:Q27088444 | Annotated while assuming this compound is actually presqualene-diphosphate |
| CE(18:1) | Metabolite | wikidata:Q27116670 | Assuming this is omega-7 type |
| Oleic acid | Metabolite | wikidata:Q207688 | Aka C18:1 (omega 9) |
| 4-methyl zymostenol | Metabolite | pubchem.compound:22212495 | |
| FF-MAS | Metabolite | cas:64284-64-6 | aka 14-demethyl-14-dehydrolanosterolC12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)C=1CC[C@]1(C)[C@@]([H])([C@@](C)([H])CC/C=C(\C)/C)CC=[C@@]21C SMILES |
| SREBF1 | GeneProduct | ensembl:ENSG00000072310 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000020538 |
| ABCA1 | GeneProduct | ensembl:ENSG00000165029 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015243 |
| CH25H | GeneProduct | ensembl:ENSG00000138135 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12642 |
| HMGCR | GeneProduct | ensembl:ENSG00000113161 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15357 |
| NR1H3 | GeneProduct | ensembl:ENSG00000025434 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000002108 |
| SOAT1 | GeneProduct | ensembl:ENSG00000057252 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20652 |
| FASN | GeneProduct | ensembl:ENSG00000169710 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000025153 |
| DHCR7 | GeneProduct | ensembl:ENSG00000172893 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13360 |
| SC5D | GeneProduct | ensembl:ENSG00000109929 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:235293 |
| EBP | GeneProduct | ensembl:ENSG00000147155 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13595 |
| NSDHL | GeneProduct | ensembl:ENSG00000147383 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18194 |
| CYP51A1 | GeneProduct | ensembl:ENSG00000001630 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13121 |
| TM7SF2 | GeneProduct | ensembl:ENSG00000149809 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:73166 |
| MSMO1 | GeneProduct | ensembl:ENSG00000052802 | aka Sc4molHomology Mapping from Mus musculus to Homo sapiens: Original ID = L:66234 |
| HSD17B7 | GeneProduct | ensembl:ENSG00000132196 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15490 |
| DHCR24 | GeneProduct | ensembl:ENSG00000116133 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74754 |
| CYP46A1 | GeneProduct | ensembl:ENSG00000036530 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13116 |
| CYP27A1 | GeneProduct | ensembl:ENSG00000135929 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:104086 |
| SOAT2 | GeneProduct | ensembl:ENSG00000167780 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:223920 |
| ACAT2 | GeneProduct | ensembl:ENSG00000120437 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:171210 |
| HMGCS1 | GeneProduct | ensembl:ENSG00000112972 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:208715 |
| HMGCS2 | GeneProduct | ensembl:ENSG00000134240 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15360 |
| MVK | GeneProduct | ensembl:ENSG00000110921 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17855 |
| PMVK | GeneProduct | ensembl:ENSG00000163344 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:68603 |
| MVD | GeneProduct | ensembl:ENSG00000167508 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:192156 |
| SQLE | GeneProduct | ensembl:ENSG00000104549 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20775 |
| IDI1 | GeneProduct | ensembl:ENSG00000067064 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:319554 |
| FDFT1 | GeneProduct | ensembl:ENSG00000079459 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14137 |
| GGPS1 | GeneProduct | ensembl:ENSG00000152904 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14593 |
| FDPS | GeneProduct | ensembl:ENSG00000160752 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:110196 |
| LSS | GeneProduct | ensembl:ENSG00000160285 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:16987 |
| NR1H2 | GeneProduct | ensembl:ENSG00000131408 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000060601 |
| ABCG1 | GeneProduct | ensembl:ENSG00000160179 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000024030 |
| MYLIP | GeneProduct | ensembl:ENSG00000007944 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000038175 |
| SREBF2 | GeneProduct | ensembl:ENSG00000198911 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000022463 |
| ACSL1 | GeneProduct | ensembl:ENSG00000151726 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000018796 |
| ACSL3 | GeneProduct | ensembl:ENSG00000123983 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032883 |
| ACSL4 | GeneProduct | ensembl:ENSG00000068366 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000031278 |
| ACOT2 | GeneProduct | ensembl:ENSG00000119673 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021226 |
| DHCR24 | Protein | ensembl:ENSG00000116133 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q8VCH6 |
| ELOVL2 | Protein | ensembl:ENSG00000197977 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021364 |
| ELOVL3 | Protein | ensembl:ENSG00000119915 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000038754 |
| ELOVL4 | Protein | ensembl:ENSG00000118402 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032262 |
| ELOVL5 | Protein | ensembl:ENSG00000012660 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032349 |
| FADS1 | Protein | ensembl:ENSG00000149485 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000010663 |
| FADS2 | Protein | ensembl:ENSG00000134824 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000024665 |
| SCD | Protein | ensembl:ENSG00000099194 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000037071 |
| CYP51A1 | Protein | ensembl:ENSG00000001630 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q8K0C4 |
| TM7SF2 | Protein | ensembl:ENSG00000149809 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q71KT5 |
| MSMO1 | Protein | ensembl:ENSG00000052802 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9CRA4 |
| NSDHL | Protein | ensembl:ENSG00000147383 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q9R1J0 |
| LBR | Protein | ensembl:ENSG00000143815 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = S:Q3U9G9 |
| TM7SF2 | Protein | ensembl:ENSG00000149809 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:73166 |
| HSD17B7 | Protein | ensembl:ENSG00000132196 | Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:15490 |
References
- Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase. Bae SH, Paik YK. Biochem J. 1997 Sep 1;326 ( Pt 2)(Pt 2):609–16. PubMed Europe PMC Scholia
- A mouse macrophage lipidome. Dennis EA, Deems RA, Harkewicz R, Quehenberger O, Brown HA, Milne SB, et al. J Biol Chem. 2010 Dec 17;285(51):39976–85. PubMed Europe PMC Scholia
- Liver x receptor modulation of gene expression leading to proluteolytic effects in primate luteal cells. Bogan RL, Debarber AE, Hennebold JD. Biol Reprod. 2012 Mar 30;86(3):89. PubMed Europe PMC Scholia
- Steroidal triterpenes of cholesterol synthesis. Ačimovič J, Rozman D. Molecules. 2013 Apr 4;18(4):4002–17. PubMed Europe PMC Scholia