Aerobic glycolysis (WP4629)
Homo sapiens
Glycolysis is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO- and H+. The free energy released in this process is used to form the ATP and NADH. This pathway was made during a research project at the UMCG, concerning changed glycolytic fluxes during the Warburg Effect. It is an extended version of the glycolysis pathway (WP534), and is descriptive of the content that is provided in the computer model of Shestov et al (2014). A second version, containing the content of the model itself as well as the corresponding supplement and article, can be found here [https://www.wikipathways.org/index.php/Pathway:WP4628] This pathway was uploaded to provide a high resolution version to readers of the thesis. Description and pathway adapted from [https://www.wikipathways.org/index.php/Pathway:WP534] Referred article: Shestov et al., 2014 [https://www.ncbi.nlm.nih.gov/pubmed/25009227]
Authors
Kelly Janssen , Egon Willighagen , Alex Pico , Denise Slenter , Eric Weitz , Finterly Hu , Kristina Hanspers , and Aishwarya IyerActivity
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Cited In
- DNA methylation of ARHGAP30 is negatively associated with ARHGAP30 expression in lung adenocarcinoma, which reduces tumor immunity and is detrimental to patient survival (2021).
- The Mixture of Ferulic Acid and P-Coumaric Acid Suppresses Colorectal Cancer through lncRNA 495810/PKM2 Mediated Aerobic Glycolysis (2022).
- Single-cell ‘omic profiles of human aortic endothelial cells in vitro and human atherosclerotic lesions ex vivo reveal heterogeneity of endothelial subtype and response to activating perturbations (2024).
- Investigation of the relationship between COVID-19 and pancreatic cancer using bioinformatics and systems biology approaches (2024).
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
gluconeogenesis pathway glycolysis/gluconeogenesis pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| ATP | Metabolite | chebi:15422 | |
| AMP | Metabolite | chebi:16027 | |
| O2e | Metabolite | chebi:26689 | |
| H | Metabolite | chebi:49637 | |
| 2PGA | Metabolite | hmdb:HMDB0000362 | |
| BPG | Metabolite | hmdb:HMDB0001270 | |
| PYR | Metabolite | hmdb:HMDB0000243 | |
| GAP | Metabolite | hmdb:HMDB0001112 | |
| G6P | Metabolite | chebi:75052 | Glucose-6-Phosphate (2-) |
| LAC | Metabolite | hmdb:HMDB0000190 | |
| PEP | Metabolite | hmdb:HMDB0000263 | |
| 3PG | Metabolite | hmdb:HMDB0000807 | |
| GLU | Metabolite | hmdb:HMDB0000122 | |
| F6P | Metabolite | chebi:61527 | |
| DHAP | Metabolite | hmdb:HMDB0001473 | |
| GLUe | Metabolite | hmdb:HMDB0000122 | |
| ADP | Metabolite | chebi:16761 | |
| FBP | Metabolite | hmdb:HMDB0001058 | |
| NAD | Metabolite | chebi:15846 | |
| P | Metabolite | chebi:28659 | |
| NADH | Metabolite | chebi:16908 | |
| LACe | Metabolite | hmdb:HMDB0000190 | |
| O2 | Metabolite | chebi:26689 | |
| HK | GeneProduct | ncbigene:3098 | |
| GLUT | GeneProduct | ncbigene:6513 | |
| PGK | GeneProduct | ncbigene:5230 | |
| ENO | GeneProduct | ncbigene:2023 | |
| GPI | GeneProduct | ncbigene:2821 | glucose-6-phosphate isomerase |
| LDH | GeneProduct | ncbigene:3939 | |
| PK | GeneProduct | ncbigene:5315 | |
| ALD | GeneProduct | ncbigene:226 | |
| PFK | GeneProduct | ncbigene:5213 | |
| GAPDH | GeneProduct | ensembl:ENSG00000111640 | |
| PGM | GeneProduct | ncbigene:5224 | |
| TPI | GeneProduct | ncbigene:7167 | |
| AK | GeneProduct | eccode:2.7.4.3 | |
| Enzyme | GeneProduct | ncbigene:2821 | glucose-6-phosphate isomerase |
References
- Biochemistry, Fifth Edition [Internet]. Berg JM, Tymoczko JL, Stryer L. 2002. 1096 p. Available from: https://books.google.com/books/about/Biochemistry_Fifth_Edition.html?hl=&id=pMxpAAAAMAAJ OpenLibrary Worldcat
- Pyruvate kinase. Classes of regulatory isoenzymes in mammalian tissues. Carbonell J, Felíu JE, Marco R, Sols A. Eur J Biochem. 1973 Aug 1;37(1):148–56. PubMed Europe PMC Scholia
- Regulation of mitochondrial oxidative phosphorylation through cell signaling. Hüttemann M, Lee I, Samavati L, Yu H, Doan JW. Biochim Biophys Acta. 2007 Dec;1773(12):1701–20. PubMed Europe PMC Scholia