Metabolism of alpha-linolenic acid (WP4586)

Homo sapiens

Metabolism of alpha-linolenic acid and linoleic acid to their respective acids. Both of these processes are catalyzed primarily by FADS1 and FADS2. The conversion of arachidonic acid to prostanoids is catalysed by prostaglandin G/H synthase 2 and the conversion of arachidonic acid to lipoxins is catalysed by different types of lipoxygenases.

Authors

Chris Gillissen , Egon Willighagen , Denise Slenter , Alex Pico , Kristina Hanspers , Finterly Hu , and Eric Weitz

Activity

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

alpha-linolenic acid metabolic pathway eicosanoid metabolic pathway linoleic acid metabolic pathway

Participants

Label Type Compact URI Comment
Arachidonic acid Metabolite chebi:15843
12-HETE Metabolite chebi:19138
Dihomo-gamma-linolenic acid Metabolite wikidata:Q415398
15-HEPE Metabolite hmdb:HMDB0010209
Arachidonic acid 5-hydroperoxide Metabolite chebi:91268
Gamma-linolenic acid Metabolite chebi:28661
12-HPETE Metabolite chebi:34145
12-HPEPE Metabolite wikidata:Q27148022
Linoleic acid Metabolite chebi:17351
12-HEPE Metabolite hmdb:HMDB0010202
15-HETE Metabolite chebi:63989
Alpha-linolenic acid Metabolite chebi:27432
Eicosapentaenoic acid Metabolite chebi:36006
Docosahexaenoic acids Metabolite chebi:36005
LXA4 Metabolite wikidata:Q27082450
LXB4 Metabolite chebi:6499
PGH2 Metabolite chebi:15554
5-HPETE Metabolite chebi:91268
PGG2 Metabolite chebi:27647
5-HETE Metabolite chebi:65341
LTA4 Metabolite chebi:15651
FADS1 Protein uniprot:O60427
FADS2 Protein uniprot:O95864
Prostaglandin G/H synthase 2 Protein uniprot:P35354
5-Lipoxygenase Protein uniprot:P09917
12-Lipoxygenase Protein uniprot:P18054
15-Lipoxygenase Protein uniprot:P16050

References

  1. The Fats of Life [Internet]. Lawrence GD. 2010. 277 p. Available from: https://books.google.com/books/about/The_Fats_of_Life.html?hl=&id=_67cmAEACAAJ OpenLibrary Worldcat