Cysteine and methionine catabolism (WP4504)

Homo sapiens

This pathway visualizes the conversion of methionine to cysteine, after which it is further metabolized in either an oxidative or non-oxidative manner. Several of these metabolites are altered in people suffering from MoCD and SO; changes in metabolite concentrations (comparing MoCD cases to controls) are highlighted in blue (see [https://www.wikipathways.org/index.php/Pathway:WP4507] for the pathway on MoCD). This pathway was inspired by Chapter 12 of the book of Blau (ISBN 3642403360 (978-3642403361)).

Authors

Denise Slenter , Egon Willighagen , Irene Hemel , Daniel Domingo-Fdez , Friederike Ehrhart , Finterly Hu , and Eric Weitz

Activity

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Organisms

Homo sapiens

Communities

Inherited Metabolic Disorders (IMD) Pathways Rare Diseases

Annotations

Pathway Ontology

methionine cycle/metabolic pathway amino acid metabolic pathway cysteine and methionine metabolic pathway cysteine metabolic pathway disease pathway methionine degradation pathway

Participants

Label Type Compact URI Comment
Methionine Metabolite chebi:57844
Tetra-hydrofolate Metabolite chebi:57453
Cystathionine Metabolite chebi:58161
-CH3 Metabolite chebi:32875
ATP Metabolite chebi:30616
Sulfate Metabolite chebi:16189
KG Metabolite chebi:16810 aka a-ketoglutarate (a-KG)
Taurine Metabolite chebi:15891
3-Mercaptopyruvic acid Metabolite chebi:57678
Sulfite Metabolite chebi:17359
S-Adenosylmethionine Metabolite chebi:59789
Cysteine Metabolite chebi:35235
CO2 Metabolite chebi:16526
SO3 2- Metabolite chebi:17359 AKA sulfite ion.
Glutathione Metabolite chebi:57925
S-Adenosylhomocysteine Metabolite chebi:57856
Dimethylglycine Metabolite chebi:58251
5-Methyltetrahydrofolate Metabolite chebi:18608
Hypotaurine Metabolite chebi:57853
Gamma-glutamylcysteine Metabolite chebi:58173
Cystine Metabolite chebi:17376
H2S Metabolite chebi:29919 aka Hydrogen sulfide
H2O Metabolite chebi:15377
S-sulfocysteine Metabolite chebi:27891
Betaine Metabolite chebi:17750
Alpha-KB Metabolite chebi:16763
Pyr Metabolite chebi:15361 AKA Pyruvic acid
Cysteine sulfinic acid Metabolite chebi:61085
Serine Metabolite chebi:33384
Glu Metabolite chebi:29985 AKA glutamine
O2 Metabolite chebi:15379
Thiosulfate(2−) Metabolite chebi:16094 AKA thiosulfate ion
B-Sulfinyl pyruvate Metabolite hmdb:HMDB0002332
Homocysteine Metabolite chebi:58199
RSSH Metabolite chebi:30605 AKA persulfurated thiol-containing compound (RSSH)
H2S Metabolite chebi:16136 aka Hydrogen sulfide
Adenosine Metabolite chebi:16335
NH4+ Metabolite chebi:28938
Glu Metabolite chebi:28300 AKA glutamine
Gly Metabolite chebi:57305 AKA glycine
MAT GeneProduct uniprot:Q00266 aka Methionine adenosyltransferase
SO GeneProduct uniprot:P51687 AKA Sulfite oxidase
MT GeneProduct brenda:2.1.1 AKA Methyltransferase
SO GeneProduct brenda:1.8.3.1 AKA Sulfite oxidase
GS Protein uniprot:P48637 AKA Glutathione synthetase
MS Protein uniprot:Q99707 AKA Methionine synthase
MPST Protein uniprot:P25325 AKA 3-mercaptopyruvate sulfurtransferase
GCS Protein uniprot:Q14TF0 AKA Glutamate-cysteine ligase
SAAH Protein uniprot:P23526 AKA Adenosylhomocysteinase
CDO Protein uniprot:Q16878 Cysteine dioxygenase type 1
CSD Protein uniprot:Q9Y600 AKA Cysteine sulfinic acid decarboxylase
CSE Protein uniprot:P35520 aka Cystathionine beta-synthase
AAT Protein uniprot:A0A140VK69 AKA Aspartate aminotransferase
BHMT Protein uniprot:Q93088 AKA Betaine--homocysteine S-methyltransferase 1
CSE Protein uniprot:P32929 Cystathionine gamma-lyase
SQR Protein uniprot:Q9Y6N5 AKA quinone oxidoreductase
AAT Protein uniprot:P17174 AKA Aspartate aminotransferase
SQR Protein uniprot:Q9Y6N5
SDO Protein uniprot:O95571 AKA sulfur dioxygenase

References

  1. Physician’s Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases [Internet]. Blau N, Duran M, Gibson KM, Dionisi-Vici C. Springer; 2014. 0 p. Available from: https://books.google.com/books/about/Physician_s_Guide_to_the_Diagnosis_Treat.html?hl=&id=wJRBnwEACAAJ OpenLibrary Worldcat
  2. Protonation state of methyltetrahydrofolate in a binary complex with cobalamin-dependent methionine synthase. Smith AE, Matthews RG. Biochemistry. 2000 Nov 14;39(45):13880–90. PubMed Europe PMC Scholia
  3. Domain alternation switches B(12)-dependent methionine synthase to the activation conformation. Bandarian V, Pattridge KA, Lennon BW, Huddler DP, Matthews RG, Ludwig ML. Nat Struct Biol. 2002 Jan;9(1):53–6. PubMed Europe PMC Scholia
  4. Dissecting the catalytic mechanism of betaine-homocysteine S-methyltransferase by use of intrinsic tryptophan fluorescence and site-directed mutagenesis. Castro C, Gratson AA, Evans JC, Jiracek J, Collinsová M, Ludwig ML, et al. Biochemistry. 2004 May 11;43(18):5341–51. PubMed Europe PMC Scholia
  5. Contribution of cysteine aminotransferase and mercaptopyruvate sulfurtransferase to hydrogen sulfide production in peripheral neurons. Miyamoto R, Otsuguro KI, Yamaguchi S, Ito S. J Neurochem. 2014 Jul;130(1):29–40. PubMed Europe PMC Scholia