IL10 anti-inflammatory signaling (WP4495)
Homo sapiens
IL-10 binds to its respective IL-10 receptor which activates the JAK/STAT pathway and MAPK pathway involving the p38 kinases. This leads to the induction of the enzyme heme oxygenase-1 (HMOX1) which is involved in the biosynthesis of heme, and catalyzes the reaction producing the heme precursor biliverdin. The ani-inflammatory actions of HMOX appear to be the result of signaling by carbon monoxide which inhibits pro-inflammatory cytokine production.
Authors
Laurent Winckers , Friederike Ehrhart , Eric Weitz , Egon Willighagen , Alex Pico , and Denise SlenterActivity
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Cited In
- Identification of high‐dimensional omics‐derived predictors for tumor growth dynamics using machine learning and pharmacometric modeling (2021).
- A Network-Based Analysis Reveals the Mechanism Underlying Vitamin D in Suppressing Cytokine Storm and Virus in SARS-CoV-2 Infection (2020).
- Finding disease modules for cancer and COVID-19 in gene co-expression networks with the Core&Peel method (2020).
- In silico transcriptional analysis of asymptomatic and severe COVID-19 patients reveals the susceptibility of severe patients to other comorbidities and non-viral pathological conditions (2023).
- Combination of Enrichment Using Gene Ontology and Transcriptomic Analysis Revealed Contribution of Interferon Signaling to Severity of COVID-19 (2022).
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Organisms
Homo sapiensCommunities
Annotations
Cell Type Ontology
macrophagePathway Ontology
signaling pathway Interleukin-10 signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Bilirubin | Metabolite | wikidata:Q104219 | |
| Heme | Metabolite | wikidata:Q189621 | |
| Biliverdin | Metabolite | wikidata:Q422964 | |
| CO | Metabolite | wikidata:Q2025 | |
| BLVRA | GeneProduct | ncbigene:644 | |
| BLVRB | GeneProduct | ncbigene:645 | |
| IL10RA | GeneProduct | ncbigene:3587 | |
| IL10RB | GeneProduct | ncbigene:3588 | |
| IL1A | GeneProduct | ncbigene:3552 | |
| IL6 | GeneProduct | ncbigene:3569 | |
| JAK1 | GeneProduct | ncbigene:3716 | |
| STAT1 | GeneProduct | ncbigene:6772 | |
| STAT2 | GeneProduct | ncbigene:6773 | |
| STAT3 | GeneProduct | ncbigene:6774 | |
| TNF | GeneProduct | ncbigene:7214 | |
| IL10 | GeneProduct | ncbigene:3586 | |
| HMOX1 | GeneProduct | ncbigene:3162 |
References
- The IL-10/STAT3-mediated anti-inflammatory response: recent developments and future challenges. Hutchins AP, Diez D, Miranda-Saavedra D. Brief Funct Genomics. 2013 Nov;12(6):489–98. PubMed Europe PMC Scholia
- A network map of Interleukin-10 signaling pathway. Verma R, Balakrishnan L, Sharma K, Khan AA, Advani J, Gowda H, et al. J Cell Commun Signal. 2016 Mar;10(1):61–7. PubMed Europe PMC Scholia