MAPK cascade (WP422)
Homo sapiens
The MAPK cascades are central signaling pathways that regulate a wide variety of stimulated cellular processes, including proliferation, differentiation, apoptosis and stress response. Therefore, dysregulation, or improper functioning of these cascades, is involved in the induction and progression of diseases such as cancer, diabetes, autoimmune diseases, and developmental abnormalities. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP422 CPTAC Assay Portal]
Authors
Nathan Salomonis , Kristina Hanspers , Ismael Reyes , Michiel Adriaens , Jildau Bouwman , Martijn Van Iersel , Daniela Digles , Martina Summer-Kutmon , Denise Slenter , Alex Pico , Eric Weitz , and Egon WillighagenActivity
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Cited In
- Altered Levels of Proteins and Phosphoproteins, in the Absence of Early Causative Transcriptional Changes, Shape the Molecular Pathogenesis in the Brain of Young Presymptomatic Ki91 SCA3/MJD Mouse (2019).
- MicroRNAs as potential biomarkers for doxorubicin-induced cardiotoxicity.
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
mitogen activated protein kinase signaling pathway mitogen activated protein kinase signaling pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| GTP | Metabolite | cas:2564-35-4 | |
| GDP | Metabolite | cas:146-91-8 | |
| MAPK14 | GeneProduct | ncbigene:1432 | |
| JUN | GeneProduct | ncbigene:3725 | |
| NRAS | GeneProduct | ncbigene:4893 | |
| MAP2K7 | GeneProduct | ncbigene:5609 | |
| MAP3K3 | GeneProduct | ncbigene:4215 | |
| MAP3K1 | GeneProduct | ncbigene:4214 | |
| ELK1 | GeneProduct | ncbigene:2002 | |
| MAP2 | GeneProduct | ncbigene:4133 | |
| MAP2K4 | GeneProduct | ncbigene:6416 | |
| HRAS | GeneProduct | ncbigene:3265 | |
| MAP3K12 | GeneProduct | ncbigene:7786 | |
| MAPK10 | GeneProduct | ncbigene:5602 | |
| MBP | GeneProduct | ncbigene:4155 | |
| MAPK12 | GeneProduct | ncbigene:6300 | |
| MAP2K6 | GeneProduct | ncbigene:5608 | |
| SIPA1 | GeneProduct | ncbigene:6494 | not confirmed SwissProt ID - mu: SPA1 MOUSE |
| RASA3 | GeneProduct | ncbigene:22821 | |
| RRAS | GeneProduct | ncbigene:6237 | |
| KRAS | GeneProduct | ncbigene:3845 | |
| MAP3K2 | GeneProduct | ncbigene:10746 | |
| MAP2K3 | GeneProduct | ncbigene:5606 | |
| PLCB3 | GeneProduct | ncbigene:5331 | |
| GRB2 | GeneProduct | ncbigene:2885 | |
| SOS2 | GeneProduct | ncbigene:6655 | |
| SOS1 | GeneProduct | ensembl:ENSG00000115904 | |
| ARAF | GeneProduct | ensembl:ENSG00000078061 | |
| BRAF | GeneProduct | ncbigene:673 | |
| RAF1 | GeneProduct | ncbigene:5894 | |
| MAP2K1 | GeneProduct | ncbigene:5604 | |
| MAPK1 | GeneProduct | ncbigene:5594 | |
| MAPK3 | GeneProduct | ncbigene:5595 | |
| MP1 | GeneProduct | ncbigene:8649 | |
| MAP2K2 | GeneProduct | ncbigene:5605 |
References
- Computational modelling reveals feedback redundancy within the epidermal growth factor receptor/extracellular-signal regulated kinase signalling pathway. Orton RJ, Sturm OE, Gormand A, Wolch W, Gilbert DR. IET Syst Biol. 2008 Jul;2(4):173–83. PubMed Europe PMC Scholia
- The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation. Plotnikov A, Zehorai E, Procaccia S, Seger R. Biochim Biophys Acta. 2011 Sep;1813(9):1619–33. PubMed Europe PMC Scholia