mRNA, protein, and metabolite inducation pathway by cyclosporin A (WP3953)

Homo sapiens

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Exposure to cyclosporin A triggers a cascade of changes in expression and abundance of various mRNAs, proteins, and metabolites, which can be measured experimentally.

Authors

Egon Willighagen , Elisa Cirillo , Kristina Hanspers , Friederike Ehrhart , and Denise Slenter

Activity

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

xenobiotic metabolic pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Pi Metabolite chebi:18367 Assuming this is Phosphate ion
L-leucine Metabolite chebi:15603
ROS Metabolite wikidata:Q424361
cysteine Metabolite chebi:15356
L-Isoleucine Metabolite chebi:17191
L-tyrosine Metabolite chebi:17895
L-Valine Metabolite chebi:16414
L-tryptophan Metabolite chebi:16828
L-threonine Metabolite chebi:16857
L-alanine Metabolite chebi:16977
L-glutamine Metabolite chebi:18050
L-asparagine Metabolite chebi:17196
ADP Metabolite hmdb:HMDB0001341
L-cysteine Metabolite hmdb:HMDB0000574
SLC3A2 GeneProduct ensembl:ENSG00000168003
SLC7A5 GeneProduct ensembl:ENSG00000103257
SLC1A5 GeneProduct ensembl:ENSG00000105281
ATF4 GeneProduct ensembl:ENSG00000128272
SLC7A11 GeneProduct ensembl:ENSG00000151012
Nrf2 Protein uniprot:Q16236
ATF4 Protein uniprot:Q96AQ3
KEAP1 Protein ensembl:ENSG00000079999

References

  1. Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress. Wilmes A, Limonciel A, Aschauer L, Moenks K, Bielow C, Leonard MO, et al. J Proteomics. 2013 Feb 21;79:180–94. PubMed Europe PMC Scholia