Estrogen receptor pathway (WP2881)

Homo sapiens

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The estrogen receptor is a nuclear receptor that is activated upon ligand binding and subsequently translocates to the nuclear. There, it activates transcription of target genes involved in essential cellular processes. The ER receptor has been implicated in a multitude of diseases, most notably cancer (breast/ovarian). Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2881 CPTAC Assay Portal]

Authors

Rianne Fijten , Kristina Hanspers , Friederike Ehrhart , Egon Willighagen , Susan Coort , Alex Pico , and Eric Weitz

Activity

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

estrogen signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Estrogen Metabolite chebi:4903
Ligand Metabolite chebi:48705
SP1 GeneProduct ensembl:ENSG00000185591
ESR1 GeneProduct ensembl:ENSG00000091831
JUN GeneProduct ensembl:ENSG00000177606
PDK4 GeneProduct ensembl:ENSG00000004799
STAT3 GeneProduct ensembl:ENSG00000168610
ACOX1 GeneProduct ensembl:ENSG00000161533
GPAM GeneProduct ensembl:ENSG00000119927
PCK1 GeneProduct ensembl:ENSG00000124253
CYP1A1 GeneProduct ensembl:ENSG00000140465
PPARA GeneProduct ensembl:ENSG00000186951
CYP1A2 GeneProduct ensembl:ENSG00000140505
NR0B2 GeneProduct ensembl:ENSG00000131910
CYP1B1 GeneProduct ensembl:ENSG00000138061

References

  1. Estrogen receptors: therapies targeted to receptor subtypes. Nilsson S, Gustafsson JÅ. Clin Pharmacol Ther. 2011 Jan;89(1):44–55. PubMed Europe PMC Scholia
  2. Pathways for ligand activated nuclear receptors to unravel the genomic responses induced by hepatotoxicants. Fijten RRR, Jennen DGJ, van Delft JHM. Curr Drug Metab. 2013 Dec;14(10):1022–8. PubMed Europe PMC Scholia