Vitamin D receptor pathway (WP2877)

Homo sapiens

Authors

Rianne Fijten , Kristina Hanspers , Friederike Ehrhart , Egon Willighagen , Kim de Nooijer , Martina Summer-Kutmon , Alex Pico , Eric Weitz , and Alvin Kho

Activity

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Cited In

• Calcitriol Promotes Differentiation of Glioma Stem-Like Cells and Increases Their Susceptibility to Temozolomide (2021).
• Identification of biomarkers and pathways for the SARS-CoV-2 infections that make complexities in pulmonary arterial hypertension patients (2021).
• Citalopram-induced pathways regulation and tentative treatment-outcome-predicting biomarkers in lymphoblastoid cell lines from depression patients (2020).
• Bioinformatics and systems-biology analysis to determine the effects of Coronavirus disease 2019 on patients with allergic asthma (2022).
• Reconstructed Human Skin with Hypodermis Shows Essential Role of Adipose Tissue in Skin Metabolism (2024).
• Human Monocytes Exposed to SARS-CoV-2 Display Features of Innate Immune Memory Producing High Levels of CXCL10 upon Restimulation (2023).
• In silico transcriptional analysis of asymptomatic and severe COVID-19 patients reveals the susceptibility of severe patients to other comorbidities and non-viral pathological conditions (2023).

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

vitamin D signaling pathway

References

1. Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes. Drocourt L, Ourlin JC, Pascussi JM, Maurel P, Vilarem MJ. J Biol Chem. 2002 Jul 12;277(28):25125–32. PubMed Europe PMC Scholia
2. The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors. Pascussi JM, Gerbal-Chaloin S, Drocourt L, Maurel P, Vilarem MJ. Biochim Biophys Acta. 2003 Feb 17;1619(3):243–53. PubMed Europe PMC Scholia
3. Dehydroepiandrosterone sulfotransferase is a target for transcriptional induction by the vitamin D receptor. Echchgadda I, Song CS, Roy AK, Chatterjee B. Mol Pharmacol. 2004 Mar;65(3):720–9. PubMed Europe PMC Scholia
4. C-jun N-terminal kinase modulates 1,25-dihydroxyvitamin D3-induced cytochrome P450 3A4 gene expression. Yasunami Y, Hara H, Iwamura T, Kataoka T, Adachi T. Drug Metab Dispos. 2004 Jul;32(7):685–8. PubMed Europe PMC Scholia
5. Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR. Handschin C, Meyer UA. Arch Biochem Biophys. 2005 Jan 15;433(2):387–96. PubMed Europe PMC Scholia
6. Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Wang TT, Tavera-Mendoza LE, Laperriere D, Libby E, MacLeod NB, Nagai Y, et al. Mol Endocrinol. 2005 Nov;19(11):2685–95. PubMed Europe PMC Scholia
7. Regulation of multiple insulin-like growth factor binding protein genes by 1alpha,25-dihydroxyvitamin D3. Matilainen M, Malinen M, Saavalainen K, Carlberg C. Nucleic Acids Res. 2005 Sep 26;33(17):5521–32. PubMed Europe PMC Scholia
8. Vitamin D receptor regulation of the steroid/bile acid sulfotransferase SULT2A1. Chatterjee B, Echchgadda I, Song CS. Methods Enzymol. 2005;400:165–91. PubMed Europe PMC Scholia
9. Vitamin D signalling pathways in cancer: potential for anticancer therapeutics. Deeb KK, Trump DL, Johnson CS. Nat Rev Cancer. 2007 Sep;7(9):684–700. PubMed Europe PMC Scholia
10. Mechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes. Han S, Chiang JYL. Drug Metab Dispos. 2009 Mar;37(3):469–78. PubMed Europe PMC Scholia
11. A genomic perspective on vitamin D signaling. Carlberg C, Seuter S. Anticancer Res. 2009 Sep;29(9):3485–93. PubMed Europe PMC Scholia
12. A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution. Ramagopalan SV, Heger A, Berlanga AJ, Maugeri NJ, Lincoln MR, Burrell A, et al. Genome Res. 2010 Oct;20(10):1352–60. PubMed Europe PMC Scholia
13. Regulation of target gene expression by the vitamin D receptor - an update on mechanisms. Pike JW, Meyer MB, Bishop KA. Rev Endocr Metab Disord. 2012 Mar;13(1):45–55. PubMed Europe PMC Scholia
14. Vitamin D receptor (VDR)-mediated actions of 1α,25(OH)₂vitamin D₃: genomic and non-genomic mechanisms. Haussler MR, Jurutka PW, Mizwicki M, Norman AW. Best Pract Res Clin Endocrinol Metab. 2011 Aug;25(4):543–59. PubMed Europe PMC Scholia
15. The first genome-wide view of vitamin D receptor locations and their mechanistic implications. Carlberg C, Seuter S, Heikkinen S. Anticancer Res. 2012 Jan;32(1):271–82. PubMed Europe PMC Scholia
16. Molecular mechanisms of vitamin D action. Haussler MR, Whitfield GK, Kaneko I, Haussler CA, Hsieh D, Hsieh JC, et al. Calcif Tissue Int. 2013 Feb;92(2):77–98. PubMed Europe PMC Scholia
17. Primary vitamin D target genes allow a categorization of possible benefits of vitamin D₃ supplementation. Carlberg C, Seuter S, de Mello VDF, Schwab U, Voutilainen S, Pulkki K, et al. PLoS One. 2013 Jul 29;8(7):e71042. PubMed Europe PMC Scholia
18. The ASAP2 gene is a primary target of 1,25-dihydroxyvitamin D3 in human monocytes and macrophages. Seuter S, Ryynänen J, Carlberg C. J Steroid Biochem Mol Biol. 2014 Oct;144 Pt A:12–8. PubMed Europe PMC Scholia
19. Gene regulatory scenarios of primary 1,25-dihydroxyvitamin d3 target genes in a human myeloid leukemia cell line. Ryynänen J, Seuter S, Campbell MJ, Carlberg C. Cancers (Basel). 2013 Oct 16;5(4):1221–41. PubMed Europe PMC Scholia
20. Vitamin D and energy homeostasis: of mice and men. Bouillon R, Carmeliet G, Lieben L, Watanabe M, Perino A, Auwerx J, et al. Nat Rev Endocrinol. 2014 Feb;10(2):79–87. PubMed Europe PMC Scholia
21. Pathways for ligand activated nuclear receptors to unravel the genomic responses induced by hepatotoxicants. Fijten RRR, Jennen DGJ, van Delft JHM. Curr Drug Metab. 2013 Dec;14(10):1022–8. PubMed Europe PMC Scholia
22. VDR primary targets by genome-wide transcriptional profiling. Goeman F, De Nicola F, D’Onorio De Meo P, Pallocca M, Elmi B, Castrignanò T, et al. J Steroid Biochem Mol Biol. 2014 Sep;143:348–56. PubMed Europe PMC Scholia
23. Primary vitamin D receptor target genes as biomarkers for the vitamin D3 status in the hematopoietic system. Wilfinger J, Seuter S, Tuomainen TP, Virtanen JK, Voutilainen S, Nurmi T, et al. J Nutr Biochem. 2014 Aug;25(8):875–84. PubMed Europe PMC Scholia
24. Changes in vitamin D target gene expression in adipose tissue monitor the vitamin D response of human individuals. Ryynänen J, Neme A, Tuomainen TP, Virtanen JK, Voutilainen S, Nurmi T, et al. Mol Nutr Food Res. 2014 Oct;58(10):2036–45. PubMed Europe PMC Scholia