PDGF pathway (WP2526)
Homo sapiens
PDGF belongs to the PDGF/VEGF (vascular endothelial growth factor) family, which is characterized by eight strictly conserved cysteine residues with similar spacing in between (Joukov et al., 1997; Heldin and Westermark, 1999). The A-, B-, C-, and D-chain genes of PDGF are localized to the chromosomes 7p22, 22q13, 4q31, and 11q22, respectively, and their expression is independently regulated. Two forms of the PDGF A-chain, containing 196 and 211 amino acid residues resulting from differential splicing of the transcript, are synthesized, dimerized, proteolytically processed in the Nterminus, and secreted from the cell as a ~30 kDa dimer. The PDGF B chain encoding 241 amino acid residues is dimerized, processed by additional proteolysis, and secreted as a 24 kDa dimer. The homodimers PDGF AA, BB, and the heterodimer AB contain three intrachain disulfide bonds. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.
For a description of pathway objects, see the WikiPathways Legend.
Authors
Arturo Manzo-Fontes P D , Martina Summer-Kutmon , Egon Willighagen , Kristina Hanspers , Zahra Roudbari , Alex Pico , and Eric WeitzActivity
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Cited In
- Understanding signaling and metabolic paths using semantified and harmonized information about biological interactions (2022).
- Hematopoietic stem-cell senescence and myocardial repair - Coronary artery disease genotype/phenotype analysis of post-MI myocardial regeneration response induced by CABG/CD133+ bone marrow hematopoietic stem cell treatment in RCT PERFECT Phase 3 (2020).
- A Practical Strategy for Exploring the Pharmacological Mechanism of Luteolin Against COVID-19/Asthma Comorbidity: Findings of System Pharmacology and Bioinformatics Analysis (2024).
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Organisms
Homo sapiensCommunities
CPTAC ONTOX PancCanNetAnnotations
Pathway Ontology
platelet-derived growth factor signaling pathway Jak-Stat signaling pathwayDisease Ontology
cancer| Label | Type | Compact URI | Comment |
|---|---|---|---|
| cAMP | Metabolite | hmdb:HMDB0000058 | |
| DAG | Metabolite | lipidmaps:LMGL02010000 | |
| PGI2 | Metabolite | hmdb:HMDB0001335 | |
| IP3 | Metabolite | chebi:16595 | |
| PIP2[4',5'] | Metabolite | lipidmaps:LMGP08010003 | |
| Ca²⁺ | Metabolite | chebi:29108 | |
| Phospholipid(containing arachidonic acid) | Metabolite | chebi:16247 | |
| [Ca²⁺+]i | Metabolite | chebi:29108 | |
| Arachidonic acid | Metabolite | hmdb:HMDB0001043 | |
| H⁺ | Metabolite | chebi:15378 | |
| Na | Metabolite | chebi:29101 | |
| NFKB1 | GeneProduct | kegg.genes:4790 | |
| JUN | GeneProduct | uniprot:P05412 | Synonyms: AP-1, c-Jun |
| RASA1 | GeneProduct | ensembl:ENSG00000145715 | Synonym: GAP |
| PTN11 | GeneProduct | uniprot:Q06124 | Synonym: SH-PTP2 |
| PDGFRB | GeneProduct | ensembl:ENSG00000113721 | |
| MAPK8 | GeneProduct | uniprot:P45983 | Synonym: JNK1 |
| MAPK3 | GeneProduct | ncbigene:5595 | |
| MAP2K4 | GeneProduct | ncbigene:6416 | Synonym: JNKK1 |
| PLCG1 | GeneProduct | ensembl:ENSG00000124181 | |
| PDGFA | GeneProduct | ncbigene:5154 | |
| MAPK1 | GeneProduct | ncbigene:5594 | |
| MAP3K1 | GeneProduct | uniprot:Q13233 | Synonym: MEKK1 |
| PDGFB | GeneProduct | ncbigene:5155 | |
| MAP2K1 | GeneProduct | uniprot:Q02750 | Originally: MP2K1 (MEK 1) |
| HRAS | GeneProduct | ncbigene:3265 | Synonyms: H-Ras-1, Ras |
| NFKB1 | GeneProduct | ncbigene:4790 | |
| PLA2G4A | GeneProduct | ensembl:ENSG00000116711 | Synonym: cPLA2 |
| ELK1 | GeneProduct | uniprot:P19419 | |
| FOS | GeneProduct | uniprot:P01100 | Synonym: c-Fos |
| SRF | GeneProduct | uniprot:P11831 | |
| NFKBIA | GeneProduct | uniprot:P25963 | Synonym: IkB alpha |
| GRB2 | Protein | uniprot:P62993 | |
| STAT1 | Protein | uniprot:P42224 | |
| STAT3 | Protein | uniprot:P40763 | |
| SOS1 | Protein | uniprot:Q07889 | |
| RAF1 | Protein | uniprot:P04049 | |
| SHC1 | Protein | uniprot:P29353 | |
| JAK1 | Protein | uniprot:P23458 | |
| COX2 | Protein | uniprot:P00403 | |
| PI3K | Protein | uniprot:P27986 | |
| SRC | Protein | uniprot:P12931 | Synonym: c-Src |
| TIAM1 | Protein | uniprot:Q13009 | |
| VAV2 | Protein | uniprot:P52735 | |
| RAC1 | Protein | uniprot:P63000 | |
| RHOA | Protein | uniprot:P61586 | |
| ARFIP2 | Protein | uniprot:P53365 | Synonym: Por1 |
| PAK1 | Protein | uniprot:Q13153 | |
| VAV1 | Protein | uniprot:P15498 | |
| CDC42 | Protein | uniprot:P60953 | |
| WASL | Protein | uniprot:O00401 | |
| IKK | Protein | uniprot:O15111 |
References
- PDGF: a multifunctional growth factor. Antoniades HN. Baillieres Clin Endocrinol Metab. 1991 Dec;5(4):595–613. PubMed Europe PMC Scholia
- PDGF and the small inducible gene (SIG) family: roles in the inflammatory response. Kawahara RS, Deng ZW, Deuel TF. Adv Exp Med Biol. 1991;305:79–87. PubMed Europe PMC Scholia
- Platelet-derived growth factor. Three isoforms that bind to two distinct cell surface receptors. Claesson-Welsh L, Heldin CH. Acta Oncol. 1989;28(3):331–4. PubMed Europe PMC Scholia
- Structure and function of platelet-derived growth factor (PDGF) and related proteins. Hannink M, Donoghue DJ. Biochim Biophys Acta. 1989 Jul 28;989(1):1–10. PubMed Europe PMC Scholia
- Platelet-derived growth factors: a family of isoforms that bind to two distinct receptors. Heldin CH, Westermark B. Br Med Bull. 1989 Apr;45(2):453–64. PubMed Europe PMC Scholia
- Structural and functional aspects of platelet-derived growth factor. Heldin CH, Hammacher A, Nistér M, Westermark B. Br J Cancer. 1988 Jun;57(6):591–3. PubMed Europe PMC Scholia
- Role of platelet-derived growth factors in physiology and medicine. Andrae J, Gallini R, Betsholtz C. Genes Dev. 2008 May 15;22(10):1276–312. PubMed Europe PMC Scholia
- PDGF function in diverse neural crest cell populations. Smith CL, Tallquist MD. Cell Adh Migr. 2010;4(4):561–6. PubMed Europe PMC Scholia
- PDGF: the nuts and bolts of signalling toolbox. Farooqi AA, Waseem S, Riaz AM, Dilawar BA, Mukhtar S, Minhaj S, et al. Tumour Biol. 2011 Dec;32(6):1057–70. PubMed Europe PMC Scholia
- Autocrine PDGF stimulation in malignancies. Heldin CH. Ups J Med Sci. 2012 May;117(2):83–91. PubMed Europe PMC Scholia