Cell differentiation - index (WP2029)

Homo sapiens

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miRNAs regulation of differentiation of numerous cell types. This diagram shows progressive commitment and subsequent differentiation of various lineages from pluripotent stem cells. Some examples of the influence by miRNAs on specific cell fates are shown. The pathway is based on [https://www.ncbi.nlm.nih.gov/pubmed/20621048 Fig 2 from Ivey and Srivastava]. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2029 CPTAC Assay Portal]

Authors

Samuel Sklar , Kristina Hanspers , Martijn Van Iersel , Alex Pico , Jonathan Mélius , Martina Summer-Kutmon , Denise Slenter , Eric Weitz , and Egon Willighagen

Activity

last edited

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Organisms

Homo sapiens

Communities

ExRNA

Annotations

Pathway Ontology

signaling pathway pertinent to development

Participants
Query Drugst.One

Label Type Compact URI Comment
MIR155 GeneProduct ensembl:ENSG00000283904
TLX1 GeneProduct ensembl:ENSG00000107807
STAT3 GeneProduct ensembl:ENSG00000168610
MIR223 GeneProduct ensembl:ENSG00000284567
TLX3 GeneProduct ensembl:ENSG00000164438
SRF GeneProduct ensembl:ENSG00000112658
TLX2 GeneProduct ensembl:ENSG00000115297
HDAC5 GeneProduct ensembl:ENSG00000108840
LEFTY2 GeneProduct ensembl:ENSG00000143768
LEFTY1 GeneProduct ensembl:ENSG00000243709
MIR20A GeneProduct ensembl:ENSG00000283762
MIR17 GeneProduct ensembl:ENSG00000284536
MIR133A2 GeneProduct ensembl:ENSG00000284508
MIR133A1 GeneProduct ensembl:ENSG00000283927
MIR145 GeneProduct ensembl:ENSG00000276365
MIR221 GeneProduct ensembl:ENSG00000207870
MIR222 GeneProduct ensembl:ENSG00000207725
MIR206 GeneProduct ensembl:ENSG00000207604
MIR214 GeneProduct ensembl:ENSG00000283844
MIR26A1 GeneProduct ensembl:ENSG00000199075
MIR26A2 GeneProduct ensembl:ENSG00000207789

References

  1. MicroRNAs as regulators of differentiation and cell fate decisions. Ivey KN, Srivastava D. Cell Stem Cell. 2010 Jul 2;7(1):36–41. PubMed Europe PMC Scholia