Apoptosis modulation and signaling (WP1772)
Homo sapiens
Apoptosis, or cell death program, can be activated by various mechanisms within the extrinsic and the intrinsic pathway. While activation of cell death receptors leads to the engagement of the extrinsic pathway, the intrinsic pathway is activated by mitochondria during cellular stress, both resulting in an activation of caspases. In the present pathway we emphasized the activation of caspases by those two pathways in pancreatic cancer (PDAC) cells. Please notice, that PDAC cells are so called type-II cells. In these cells the activation of cell death receptors is not sufficient to activated caspases. By cleavage of Bid, type-II cells activate the intrinsic pathway as "amplification loop". Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP1772 CPTAC Assay Portal]
Authors
Felix Rckert , Kristina Hanspers , Frances , Martijn Van Iersel , Egon Willighagen , Zahra Roudbari , Marianthi Kalafati , Alex Pico , Ryan Miller , Marvin Martens , Friederike Ehrhart , Anders Riutta , Daniel Domingo-Fdez , and Eric WeitzActivity
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Cited In
- Investigating the Molecular Processes behind the Cell-Specific Toxicity Response to Titanium Dioxide Nanobelts (2021).
- 24h-gene variation effect of combined bevacizumab/erlotinib in advanced non-squamous non-small cell lung cancer using exon array blood profiling (2017).
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Organisms
Homo sapiensCommunities
Annotations
Pathway Ontology
regulatory pathway signaling pathway apoptotic cell death pathway| Label | Type | Compact URI | Comment |
|---|---|---|---|
| Ca2+ | Metabolite | hmdb:HMDB0000464 | |
| JNK | GeneProduct | hgnc.symbol:MAPK8 | |
| MIR29B1 | GeneProduct | ensembl:ENSG00000283797 | |
| BIRC3 | GeneProduct | hgnc.symbol:BIRC3 | |
| IL1R1 | GeneProduct | hgnc.symbol:IL1R1 | |
| JUN | GeneProduct | hgnc.symbol:JUN | |
| NFKBIA | GeneProduct | hgnc.symbol:NFKBIA | |
| DAXX | GeneProduct | hgnc.symbol:DAXX | |
| BIRC5 | GeneProduct | ensembl:ENSG00000089685 | |
| BCL2A1 | GeneProduct | hgnc.symbol:BCL2A1 | |
| CASP2 | GeneProduct | ncbigene:835 | |
| APAF1 | GeneProduct | hgnc.symbol:APAF1 | |
| BOK | GeneProduct | hgnc.symbol:BOK | |
| IKK | GeneProduct | hgnc.symbol:IKBKB | |
| BCL2L11 | GeneProduct | ensembl:ENSG00000153094 | |
| BAX | GeneProduct | hgnc.symbol:BAX | |
| TOLLIP | GeneProduct | hgnc.symbol:TOLLIP | |
| TNFRSF11B | GeneProduct | hgnc.symbol:ENSG00000164761 | |
| IL1R2 | GeneProduct | hgnc.symbol:IL1R2 | |
| MADD | GeneProduct | hgnc.symbol:MADD | |
| CFLAR | GeneProduct | hgnc.symbol:CFLAR | |
| AIFM1 | GeneProduct | ncbigene:9131 | |
| TRADD | GeneProduct | hgnc.symbol:TRADD | |
| FASLG | GeneProduct | hgnc.symbol:FASLG | |
| TRAF6 | GeneProduct | hgnc.symbol:TRAF6 | |
| CASP3 | GeneProduct | hgnc.symbol:CASP3 | |
| CASP4 | GeneProduct | ncbigene:837 | |
| NIK | GeneProduct | hgnc.symbol:MAP3K14 | |
| TNFRSF25 | GeneProduct | hgnc.symbol:TNFRSF25 | |
| ERK | GeneProduct | hgnc.symbol:MAPK3 | |
| MYD88 | GeneProduct | hgnc.symbol:MYD88 | |
| CASP6 | GeneProduct | hgnc.symbol:CASP6 | |
| TNFRSF1B | GeneProduct | hgnc.symbol:TNFRSF1B | |
| CASP2 | GeneProduct | hgnc:1503 | |
| CRADD | GeneProduct | hgnc.symbol:CRADD | |
| SEPTIN4 | GeneProduct | ensembl:ENSG00000108387 | |
| CASP9 | GeneProduct | hgnc.symbol:CASP9 | |
| CASP1 | GeneProduct | ncbigene:834 | |
| CDKN2A | GeneProduct | hgnc.symbol:CDKN2A | |
| BLK | GeneProduct | hgnc.symbol:BLK | |
| BAG3 | GeneProduct | hgnc.symbol:BAG3 | |
| HSPA1A | GeneProduct | ncbigene:3303 | |
| PIDD | GeneProduct | ncbigene:55367 | |
| BIRC6 | GeneProduct | hgnc.symbol:ENSG00000115760 | |
| BIK | GeneProduct | hgnc.symbol:BIK | |
| CYCS | GeneProduct | ensembl:ENSG00000172115 | |
| MAP3K5 | GeneProduct | hgnc.symbol:MAP3K5 | |
| BAD | GeneProduct | hgnc.symbol:BAD | |
| BCL2L2 | GeneProduct | hgnc.symbol:BCL2L2 | |
| BID | GeneProduct | hgnc.symbol:BID | |
| TP53 | GeneProduct | ncbigene:7157 | |
| CASP7 | GeneProduct | hgnc.symbol:CASP7 | |
| TNFRSF1A | GeneProduct | hgnc.symbol:TNFRSF1A | |
| HRK | GeneProduct | hgnc.symbol:HRK | |
| PRKD1 | GeneProduct | ncbigene:5587 | |
| MT-RNR2 | GeneProduct | ensembl:ENSG00000210082 | |
| NAIP | GeneProduct | ncbigene:4671 | |
| XIAP | GeneProduct | ncbigene:331 | |
| CAPNS1 | GeneProduct | hgnc.symbol:CAPNS1 | |
| AIFM2 | GeneProduct | ncbigene:84883 | |
| MCL1 | GeneProduct | hgnc.symbol:MCL1 | |
| BMF | GeneProduct | hgnc.symbol:BMF | |
| TNFRSF6B | GeneProduct | hgnc.symbol:TNFRSF6B | |
| PTRH2 | GeneProduct | ensembl:ENSG00000141378 | |
| RIPK1 | GeneProduct | ncbigene:8737 | |
| PTPN13 | GeneProduct | ensembl:ENSG00000163629 | |
| TNFRSF10A | GeneProduct | ensembl:ENSG00000104689 | |
| ENDOG | GeneProduct | hgnc.symbol:ENDOG | |
| CASP2 | GeneProduct | hgnc.symbol:CASP2 | |
| TNFSF10 | GeneProduct | ensembl:ENSG00000121858 | |
| BAK1 | GeneProduct | hgnc.symbol:BAK1 | |
| HTRA2 | GeneProduct | ensembl:ENSG00000115317 | |
| DFFA | GeneProduct | hgnc.symbol:DFFA | |
| BNIP3 | GeneProduct | hgnc.symbol:BNIP3 | |
| PEA15 | GeneProduct | ncbigene:8682 | |
| CASP10 | GeneProduct | hgnc.symbol:CASP10 | |
| FOS | GeneProduct | hgnc.symbol:FOS | |
| BCL2L10 | GeneProduct | hgnc.symbol:BCL2L10 | |
| FADD | GeneProduct | hgnc.symbol:FADD | |
| DFFB | GeneProduct | hgnc.symbol:DFFB | |
| FAS | GeneProduct | hgnc.symbol:FAS | |
| CASP8 | GeneProduct | hgnc.symbol:CASP8 | |
| TNFRSF10D | GeneProduct | ensembl:ENSG00000173530 | |
| BCL2 | GeneProduct | hgnc.symbol:BCL2 | |
| DIABLO | GeneProduct | ensembl:ENSG00000184047 | |
| IRAK1 | GeneProduct | hgnc.symbol:IRAK1 | |
| IG20 | GeneProduct | ensembl:ENSG00000110514 | |
| NFKB1 | GeneProduct | hgnc.symbol:NFKB1 | |
| TNFRSF10B | GeneProduct | ensembl:ENSG00000120889 | |
| BCL-XL | GeneProduct | hgnc.symbol:BCL2L1 | |
| TRAF3 | GeneProduct | hgnc.symbol:TRAF3 | |
| BCL2L1 | GeneProduct | hgnc.symbol:ENSG00000171552 | |
| BIRC2 | GeneProduct | hgnc.symbol:BIRC2 | |
| BIRC7 | GeneProduct | ensembl:ENSG00000101197 | |
| BBC3 | GeneProduct | ensembl:ENSG00000105327 | |
| TNFRSF10C | GeneProduct | ensembl:ENSG00000173535 | |
| PMAIP1 | GeneProduct | ensembl:ENSG00000141682 | |
| MIR29B2 | GeneProduct | ensembl:ENSG00000284203 |
References
- mir-29 regulates Mcl-1 protein expression and apoptosis. Mott JL, Kobayashi S, Bronk SF, Gores GJ. Oncogene. 2007 Sep 13;26(42):6133–40. PubMed Europe PMC Scholia
- Examination of apoptosis signaling in pancreatic cancer by computational signal transduction analysis. Rückert F, Dawelbait G, Winter C, Hartmann A, Denz A, Ammerpohl O, et al. PLoS One. 2010 Aug 19;5(8):e12243. PubMed Europe PMC Scholia