Angiogenesis (WP1539)
Homo sapiens
This pathway is a concise and simplified version of the basic proteins involved in angiogenesis. The proces is regulated by hyopoxia, which results in the transcription of eg. VEGF1, FGF2, PDGFbeta, MMP9, MMP2 and Ang1. These proteins bind to their receptors and by doing this they initiate different pathways that result in vessel formation. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP1539 CPTAC Assay Portal]
Authors
Laur S , Kristina Hanspers , Alex Pico , James Bjork , Martijn Van Iersel , Egon Willighagen , Zahra Roudbari , Marianthi Kalafati , Martina Summer-Kutmon , and Eric WeitzActivity
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Cited In
- Deepening the knowledge of rare diseases dependent on angiogenesis through semantic similarity clustering and network analysis (2022).
- Comprehensive Statistical and Bioinformatics Analysis in the Deciphering of Putative Mechanisms by Which Lipid-Associated GWAS Loci Contribute to Coronary Artery Disease (2022).
- Heterogeneity of Lipid and Protein Cartilage Profiles Associated with Human Osteoarthritis with or without Type 2 Diabetes Mellitus (2021).
- Long Term Culture of the A549 Cancer Cell Line Promotes Multilamellar Body Formation and Differentiation towards an Alveolar Type II Pneumocyte Phenotype (2016).
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Organisms
Homo sapiensCommunities
CPTAC PancCanNetAnnotations
Pathway Ontology
regulatory pathway signaling pathway pertinent to development| Label | Type | Compact URI | Comment |
|---|---|---|---|
| MAPK1 | GeneProduct | ensembl:ENSG00000100030 | |
| ARNT | GeneProduct | ncbigene:405 | |
| PI3K | GeneProduct | ncbigene:5290 | |
| sTIE2 | GeneProduct | ncbigene:7010 | |
| NOS | GeneProduct | ensembl:ENSG00000164867 | |
| Ang 1 | GeneProduct | uniprot:Q15389 | |
| SMAD1 | GeneProduct | ensembl:ENSG00000170365 | |
| PLCG1 | GeneProduct | ensembl:ENSG00000124181 | |
| MMP9 | GeneProduct | ensembl:ENSG00000100985 | |
| FGF2 | GeneProduct | ensembl:ENSG00000138685 | |
| CBP | GeneProduct | ncbigene:1387 | |
| PDGFB | GeneProduct | ensembl:ENSG00000100311 | |
| Ang 1 | GeneProduct | uniprot:Q15389 | |
| TIE2 | GeneProduct | ncbigene:7010 | |
| p38 MAPK | GeneProduct | ncbigene:1432 | |
| FAK | GeneProduct | uniprot:Q05397 | |
| PDGFRA | GeneProduct | uniprot:P16234 | |
| VEGFA | GeneProduct | uniprot:P15692 | |
| HIF1A | GeneProduct | ncbigene:3091 | |
| TIMP2 | GeneProduct | ensembl:ENSG00000035862 | |
| MMP2 | GeneProduct | ensembl:ENSG00000100985 | |
| SRC | GeneProduct | ensembl:ENSG00000197122 | |
| PDGFB | GeneProduct | ensembl:ENSG00000100311 | |
| FLT1 | GeneProduct | ensembl:ENSG00000102755 | |
| VEGFR2 | GeneProduct | ncbigene:3791 | |
| MMP2 | GeneProduct | ensembl:ENSG00000100985 | |
| HIF1A | GeneProduct | ncbigene:3091 | |
| FGFR2 | GeneProduct | ncbigene:2263 | |
| MMP9 | GeneProduct | ensembl:ENSG00000100985 | |
| FGF2 | GeneProduct | ensembl:ENSG00000138685 | |
| AKT1 | GeneProduct | ensembl:ENSG00000142208 | |
| VEGFA | GeneProduct | uniprot:P15692 | |
| TIMP3 | Protein | ensembl:ENSG00000100234 |
References
- High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Millauer B, Wizigmann-Voos S, Schnürch H, Martinez R, Møller NP, Risau W, et al. Cell. 1993 Mar 26;72(6):835–46. PubMed Europe PMC Scholia
- Angiopoietin-1 induces sprouting angiogenesis in vitro. Koblizek TI, Weiss C, Yancopoulos GD, Deutsch U, Risau W. Curr Biol. 1998 Apr 23;8(9):529–32. PubMed Europe PMC Scholia
- Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Bergers G, Brekken R, McMahon G, Vu TH, Itoh T, Tamaki K, et al. Nat Cell Biol. 2000 Oct;2(10):737–44. PubMed Europe PMC Scholia
- Vascular endothelial growth factor and basic fibroblast growth factor differentially modulate early postnatal coronary angiogenesis. Tomanek RJ, Sandra A, Zheng W, Brock T, Bjercke RJ, Holifield JS. Circ Res. 2001 Jun 8;88(11):1135–41. PubMed Europe PMC Scholia
- Angiogenesis of the heart. Kutryk MJB, Stewart DJ. Microsc Res Tech. 2003 Feb 1;60(2):138–58. PubMed Europe PMC Scholia
- The role of the matrix metalloproteinases during in vitro vessel formation. Burbridge MF, Cogé F, Galizzi JP, Boutin JA, West DC, Tucker GC. Angiogenesis. 2002;5(3):215–26. PubMed Europe PMC Scholia
- Growth factor activation in myocardial vascularization: therapeutic implications. Tomanek RJ, Zheng W, Yue X. Mol Cell Biochem. 2004 Sep;264(1–2):3–11. PubMed Europe PMC Scholia
- Therapeutic angiogenesis and vasculogenesis for tissue regeneration. Madeddu P. Exp Physiol. 2005 May;90(3):315–26. PubMed Europe PMC Scholia
- The matrix revolutions: matrix metalloproteinase, vasculogenesis, and ischemic tissue repair. Renault MA, Losordo DW. Circ Res. 2007 Mar 30;100(6):749–50. PubMed Europe PMC Scholia
- Angiopoietin-1 in the treatment of ischemia and sepsis. Novotny NM, Lahm T, Markel TA, Crisostomo PR, Wang M, Wang Y, et al. Shock. 2009 Apr;31(4):335–41. PubMed Europe PMC Scholia
- PDGF and vessel maturation. Hellberg C, Ostman A, Heldin CH. Recent Results Cancer Res. 2010;180:103–14. PubMed Europe PMC Scholia
- Synergistic effects of FGF-2 and PDGF-BB on angiogenesis and muscle regeneration in rabbit hindlimb ischemia model. Li J, Wei Y, Liu K, Yuan C, Tang Y, Quan Q, et al. Microvasc Res. 2010 Jul;80(1):10–7. PubMed Europe PMC Scholia