Pleural mesothelioma (WP5087)

Homo sapiens

Open in new tab Open in NDEx Open in Newt (SBGN)
Download PNG Download SVG Download JSON Download GPML Learn more about Downloads
Mesothelioma

Authors

Franziska Kreidl , Marvin Martens , Eric Weitz , Finterly Hu , Egon Willighagen , Lauren J. Dupuis , Alex Pico , Lars Willighagen , and Kristina Hanspers

Activity

last edited

Discuss this pathway

Check for ongoing discussions or start your own.

Cited In

Are you planning to include this pathway in your next publication? See How to Cite and add a link here to your paper once it's online.

Organisms

Homo sapiens

Communities

CPTAC Rare Diseases

Annotations

Disease Ontology

malignant pleural mesothelioma

Pathway Ontology

disease pathway altered autophagy pathway

Cell Type Ontology

mesothelial cell of pleura mesothelial cell

Participants
Query Drugst.One

Label Type Compact URI Comment
Ca2+ Metabolite chebi:29108
glucose Metabolite chebi:17234
PIP3 Metabolite chebi:16618
ROS Metabolite chebi:70982
c-fos Metabolite chebi:62519
GDP Metabolite chebi:17552
PIP2 Metabolite chebi:18348
RNS Metabolite wikidata:Q225595
GTP Metabolite chebi:37565
Arginine Metabolite chebi:29016
Tryptophan Metabolite chebi:16828
Kynurenine Metabolite chebi:28683
prostaglandin E2 Metabolite chebi:15551
TCF7L1 GeneProduct ensembl:ENSG00000152284
TCF7 GeneProduct ensembl:ENSG00000081059
ASXL1 GeneProduct ensembl:ENSG00000171456
CTGF GeneProduct ensembl:ENSG00000118523
TGFB1 GeneProduct ensembl:ENSG00000105329
RBBP4 GeneProduct ensembl:ENSG00000162521
MAPK8 GeneProduct ensembl:ENSG00000107643
MYC GeneProduct ensembl:ENSG00000136997
PLCB4 GeneProduct ensembl:ENSG00000101333
KDM6A GeneProduct ensembl:ENSG00000147050
PORCN GeneProduct ensembl:ENSG00000102312
CSF2 GeneProduct ensembl:ENSG00000164400
SUZ12 GeneProduct ensembl:ENSG00000178691
PD-L1 GeneProduct ensembl:ENSG00000120217
RASSF1 GeneProduct ensembl:ENSG00000068028
DKK2 GeneProduct ensembl:ENSG00000155011
RING1 GeneProduct ensembl:ENSG00000204227
AREG GeneProduct ensembl:ENSG00000109321
ITGB1 GeneProduct ensembl:ENSG00000150093
BARD1 GeneProduct ensembl:ENSG00000138376
ITGA1 GeneProduct ensembl:ENSG00000213949
CXCL12 GeneProduct ensembl:ENSG00000107562
PHC1 GeneProduct ensembl:ENSG00000111752
TGFA GeneProduct ensembl:ENSG00000163235
SOST GeneProduct ensembl:ENSG00000167941
PDGFRA GeneProduct ensembl:ENSG00000134853
RASSF4 GeneProduct ensembl:ENSG00000107551
BTC GeneProduct ensembl:ENSG00000174808
HCFC1 GeneProduct ensembl:ENSG00000172534
KMT2C GeneProduct ensembl:ENSG00000055609
ACTA2 GeneProduct ensembl:ENSG00000107796
FGF2 GeneProduct ensembl:ENSG00000138685
BAG2 GeneProduct ensembl:ENSG00000112208
DDIT3 GeneProduct ensembl:ENSG00000175197
RASSF3 GeneProduct ensembl:ENSG00000153179
ITPR3 GeneProduct ensembl:ENSG00000096433
EED GeneProduct ensembl:ENSG00000074266
IGF1 GeneProduct ensembl:ENSG00000017427
IDO1 GeneProduct ensembl:ENSG00000131203
VGLL4 GeneProduct ensembl:ENSG00000144560
CYCS GeneProduct ensembl:ENSG00000172115 Cytochrome C
CCND1 GeneProduct ensembl:ENSG00000110092
FGF1 GeneProduct ensembl:ENSG00000113578
MCU GeneProduct ensembl:ENSG00000156026
HGF GeneProduct ensembl:ENSG00000019991
LAMA1 GeneProduct ensembl:ENSG00000101680
WIF1 GeneProduct ensembl:ENSG00000156076
LGALS9 GeneProduct ensembl:ENSG00000168961
VEGFA GeneProduct ensembl:ENSG00000112715
RASSF2 GeneProduct ensembl:ENSG00000101265
EZH2 GeneProduct ensembl:ENSG00000106462
CER1 GeneProduct ensembl:ENSG00000147869
RASSF7 GeneProduct ensembl:ENSG00000099849
RAF GeneProduct ensembl:ENSG00000132155
ACTA1 GeneProduct ensembl:ENSG00000143632
FN1 GeneProduct ensembl:ENSG00000115414
IGF1R GeneProduct ensembl:ENSG00000140443
ATF3 GeneProduct ensembl:ENSG00000162772
SLC3A2 GeneProduct ensembl:ENSG00000168003
COL4A1 GeneProduct ensembl:ENSG00000187498
PPARGC1A GeneProduct ensembl:ENSG00000109819
NOTUM GeneProduct ensembl:ENSG00000185269
DKK4 GeneProduct ensembl:ENSG00000104371
BMI1 GeneProduct ensembl:ENSG00000168283
IL6 GeneProduct ensembl:ENSG00000136244
FOXM1 GeneProduct ensembl:ENSG00000111206
DKK1 GeneProduct ensembl:ENSG00000107984
LAMC1 GeneProduct ensembl:ENSG00000135862
MDM4 GeneProduct ensembl:ENSG00000198625
SERPINF1 GeneProduct ensembl:ENSG00000132386
SPARC GeneProduct ensembl:ENSG00000113140
ACTB GeneProduct ensembl:ENSG00000075624
CSF1 GeneProduct ensembl:ENSG00000184371
LIMD1 GeneProduct ensembl:ENSG00000144791
RASSF6 GeneProduct ensembl:ENSG00000169435
FGFR1 GeneProduct ensembl:ENSG00000077782
SLC2A1 GeneProduct ensembl:ENSG00000117394
CCL2 GeneProduct ensembl:ENSG00000108691
IL10 GeneProduct ensembl:ENSG00000136634
CTNNA1 GeneProduct ensembl:ENSG00000044115
CD44 GeneProduct ensembl:ENSG00000026508
MET GeneProduct ensembl:ENSG00000105976
RASSF5 GeneProduct ensembl:ENSG00000266094
LIN28B GeneProduct ensembl:ENSG00000187772
YY1 GeneProduct ensembl:ENSG00000100811
KITLG GeneProduct ensembl:ENSG00000049130
RNF2 GeneProduct ensembl:ENSG00000121481
HBEGF GeneProduct ensembl:ENSG00000113070
KIT GeneProduct ensembl:ENSG00000157404
EGFR GeneProduct ensembl:ENSG00000146648
BRCA1 GeneProduct ensembl:ENSG00000012048
CDK4 GeneProduct ensembl:ENSG00000135446
TP53 GeneProduct ensembl:ENSG00000141510
BCL2 GeneProduct ensembl:ENSG00000171791
CDKN2A GeneProduct ensembl:ENSG00000147889
BAX GeneProduct ensembl:ENSG00000087088
RAGE GeneProduct ensembl:ENSG00000204305
CNNE1 GeneProduct ensembl:ENSG00000105173
HIF1A GeneProduct ensembl:ENSG00000100644
MCL1 GeneProduct ensembl:ENSG00000143384
MMP9 GeneProduct ensembl:ENSG00000100985
CDK7 GeneProduct ensembl:ENSG00000134058
PDK1 GeneProduct ensembl:ENSG00000152256
MAP3K5 GeneProduct ensembl:ENSG00000197442
NF2 GeneProduct ensembl:ENSG00000186575
RAS GeneProduct ensembl:ENSG00000174775
NF-KB GeneProduct ensembl:ENSG00000109320
MEK5 GeneProduct ensembl:ENSG00000137764
GRB2 GeneProduct ensembl:ENSG00000177885
TSC1 GeneProduct ensembl:ENSG00000165699
CUL1 GeneProduct ensembl:ENSG00000055130
ATM GeneProduct ensembl:ENSG00000149311
STAT GeneProduct ensembl:ENSG00000115415
SP1 GeneProduct ensembl:ENSG00000185591
MAPK14 GeneProduct ensembl:ENSG00000112062
SHC GeneProduct ensembl:ENSG00000160691
SAV1 GeneProduct ensembl:ENSG00000151748
ERK2 GeneProduct ensembl:ENSG00000100030
LATS1 GeneProduct ensembl:ENSG00000131023
ATG13 GeneProduct ensembl:ENSG00000175224
JAK GeneProduct ensembl:ENSG00000162434
CDKN1A GeneProduct ensembl:ENSG00000124762 P21
CDK2 GeneProduct ensembl:ENSG00000123374
SETD2 GeneProduct ensembl:ENSG00000181555
ULK2 GeneProduct ensembl:ENSG00000083290
HMGB1 GeneProduct ensembl:ENSG00000189403
MMP2 GeneProduct ensembl:ENSG00000087245
MAP2K4 GeneProduct ensembl:ENSG00000065559
E2F1 GeneProduct ensembl:ENSG00000101412
LATS2 GeneProduct ensembl:ENSG00000150457
PDGF GeneProduct ensembl:ENSG00000197461
BTRC GeneProduct ensembl:ENSG00000166167
MAX GeneProduct ensembl:ENSG00000125952
KIBRA GeneProduct ensembl:ENSG00000113645
Cyclin D GeneProduct ensembl:ENSG00000110092
GABPA GeneProduct ensembl:ENSG00000154727
IL-1B GeneProduct ensembl:ENSG00000125538
FOXO1 GeneProduct ensembl:ENSG00000150907
PUMA GeneProduct ensembl:ENSG00000105327
MST1 GeneProduct ensembl:ENSG00000173531
ERK1 GeneProduct ensembl:ENSG00000102882
EIF4 GeneProduct ensembl:ENSG00000114867
c-jun GeneProduct ensembl:ENSG00000177606
NLRP3 GeneProduct ensembl:ENSG00000162711
p16INK4A GeneProduct uniprot:P42771
VEGF GeneProduct ensembl:ENSG00000112715
FAK GeneProduct ensembl:ENSG00000169398
RHEB GeneProduct ensembl:ENSG00000106615
MDM2 GeneProduct ensembl:ENSG00000135679
AJUBA GeneProduct ensembl:ENSG00000129474
SETD5 GeneProduct ensembl:ENSG00000168137
RPS6KA1 GeneProduct ensembl:ENSG00000117676
MAP2K1 GeneProduct ensembl:ENSG00000169032
MAP3K9 GeneProduct ensembl:ENSG00000006432
PIGF GeneProduct ensembl:ENSG00000151665
fra-1 GeneProduct ensembl:ENSG00000175592
TEAD1 GeneProduct ensembl:ENSG00000187079
TSC2 GeneProduct ensembl:ENSG00000103197
CASPASE-1 GeneProduct ensembl:ENSG00000137752
AMOT GeneProduct ensembl:ENSG00000126016
DR5 GeneProduct ensembl:ENSG00000196363
4E-BP GeneProduct ensembl:ENSG00000187840
SRC GeneProduct ensembl:ENSG00000197122
BAP1 GeneProduct ensembl:ENSG00000163930 The Cancer Genome Atlas Data Portal entry for BAP1: https://portal.gdc.cancer.gov/genes/ENSG00000163930
Onco KnowledgeBase entry for BAP1: https://www.oncokb.org/gene/BAP1
neXtProt entry for BAP1: https://www.nextprot.org/entry/NX_Q92560/
PTEN GeneProduct ensembl:ENSG00000171862
ERK5 GeneProduct ensembl:ENSG00000166484
MAP2K6 GeneProduct ensembl:ENSG00000108984
TERT GeneProduct ensembl:ENSG00000164362
BECLIN1 GeneProduct ensembl:ENSG00000126581
BAK GeneProduct ensembl:ENSG00000030110
ULK1 GeneProduct ensembl:ENSG00000177169
SETDB1 GeneProduct ensembl:ENSG00000143379
MAD1 GeneProduct ensembl:ENSG00000002822
BCLXL GeneProduct ensembl:ENSG00000171791
PRB1 GeneProduct ensembl:ENSG00000251655
SOS GeneProduct ensembl:ENSG00000115904
AP2 GeneProduct ensembl:ENSG00000170323
FIP200 GeneProduct ensembl:ENSG00000023287
MKNK1 GeneProduct ensembl:ENSG00000079277
MAPKAPK2 GeneProduct ensembl:ENSG00000162889
YAP GeneProduct ensembl:ENSG00000137693
WWTR1 GeneProduct ensembl:ENSG00000018408
P21 GeneProduct ensembl:ENSG00000124762
PRAS40 GeneProduct ensembl:ENSG00000204673
TEL2 GeneProduct ensembl:ENSG00000100726
TTI1 GeneProduct ensembl:ENSG00000101407
MLST8 GeneProduct ensembl:ENSG00000167965
DEPTOR GeneProduct ensembl:ENSG00000155792
MTOR GeneProduct ensembl:ENSG00000198793
Pro IL-1B GeneProduct ensembl:ENSG00000125538
PAK1 GeneProduct ensembl:ENSG00000149269
PAK2 GeneProduct ensembl:ENSG00000180370
PAK3 GeneProduct ensembl:ENSG00000077264
PAK4 GeneProduct ensembl:ENSG00000130669
PAK5 GeneProduct ensembl:ENSG00000101349
PAK6 GeneProduct ensembl:ENSG00000137843
VEGFB GeneProduct ensembl:ENSG00000173511
VEGFC GeneProduct ensembl:ENSG00000150630
VEGFD GeneProduct ensembl:ENSG00000165197
PDGFA GeneProduct ensembl:ENSG00000197461
PDGFB GeneProduct ensembl:ENSG00000100311
PDGFC GeneProduct ensembl:ENSG00000145431
PDGFD GeneProduct ensembl:ENSG00000170962
MMP3 GeneProduct ensembl:ENSG00000149968
MMP14 GeneProduct ensembl:ENSG00000157227
EGF GeneProduct ensembl:ENSG00000138798
FGFR2 GeneProduct ensembl:ENSG00000066468
FGFR3 GeneProduct ensembl:ENSG00000068078
FGFR4 GeneProduct ensembl:ENSG00000160867
IGF2 GeneProduct ensembl:ENSG00000167244
PDGFRB GeneProduct ensembl:ENSG00000113721
COL4A2 GeneProduct ensembl:ENSG00000134871
COL4A3 GeneProduct ensembl:ENSG00000169031
COL4A4 GeneProduct ensembl:ENSG00000081052
COL4A5 GeneProduct ensembl:ENSG00000188153
COL4A6 GeneProduct ensembl:ENSG00000197565
LAMA2 GeneProduct ensembl:ENSG00000196569
LAMA3 GeneProduct ensembl:ENSG00000053747
LAMA4 GeneProduct ensembl:ENSG00000112769
LAMA5 GeneProduct ensembl:ENSG00000130702
LAMB1 GeneProduct ensembl:ENSG00000091136
LAMB2 GeneProduct ensembl:ENSG00000172037
LAMB3 GeneProduct ensembl:ENSG00000196878
LAMC2 GeneProduct ensembl:ENSG00000058085
LAMC3 GeneProduct ensembl:ENSG00000050555
ITGA2 GeneProduct ensembl:ENSG00000164171
ITGA3 GeneProduct ensembl:ENSG00000005884
ITGA4 GeneProduct ensembl:ENSG00000115232
ITGAV GeneProduct ensembl:ENSG00000138448
ITGA6 GeneProduct ensembl:ENSG00000091409
ITGB2 GeneProduct ensembl:ENSG00000160255
ITGB3 GeneProduct ensembl:ENSG00000259207
ITGB4 GeneProduct ensembl:ENSG00000132470
CCL4 GeneProduct ensembl:ENSG00000275302
CXCL10 GeneProduct ensembl:ENSG00000169245
CXCL5 GeneProduct ensembl:ENSG00000163735
SLC7A5 GeneProduct ensembl:ENSG00000103257
IL34 GeneProduct ensembl:ENSG00000157368
CXCL1 GeneProduct ensembl:ENSG00000163739
CSF3 GeneProduct ensembl:ENSG00000108342
CDH5 GeneProduct ensembl:ENSG00000179776
CDH1 GeneProduct ensembl:ENSG00000039068
CDH10 GeneProduct ensembl:ENSG00000040731
CDH17 GeneProduct ensembl:ENSG00000079112
CDH9 GeneProduct ensembl:ENSG00000113100
CDH16 GeneProduct ensembl:ENSG00000166589
CDH6 GeneProduct ensembl:ENSG00000113361
CDH13 GeneProduct ensembl:ENSG00000140945
CDH20 GeneProduct ensembl:ENSG00000101542
CDH2 GeneProduct ensembl:ENSG00000170558
CDH19 GeneProduct ensembl:ENSG00000071991
CDH22 GeneProduct ensembl:ENSG00000149654
CDH8 GeneProduct ensembl:ENSG00000150394
CDH24 GeneProduct ensembl:ENSG00000139880
CDH18 GeneProduct ensembl:ENSG00000145526
CDH12 GeneProduct ensembl:ENSG00000154162
CDH7 GeneProduct ensembl:ENSG00000081138
CDH15 GeneProduct ensembl:ENSG00000129910
CDH11 GeneProduct ensembl:ENSG00000140937
CDH3 GeneProduct ensembl:ENSG00000062038
CDH4 GeneProduct ensembl:ENSG00000179242
PRKAB2 GeneProduct ensembl:ENSG00000131791
PRKAB1 GeneProduct ensembl:ENSG00000111725
PRKAA2 GeneProduct ensembl:ENSG00000162409
PRKAG1 GeneProduct ensembl:ENSG00000181929
PRKAA1 GeneProduct ensembl:ENSG00000132356
PRKAG2 GeneProduct ensembl:ENSG00000106617
PRKAG3 GeneProduct ensembl:ENSG00000115592
KDR GeneProduct ensembl:ENSG00000128052
INSR GeneProduct ensembl:ENSG00000171105
EPHA2 GeneProduct ensembl:ENSG00000142627
CSF1R GeneProduct ensembl:ENSG00000182578
FLT1 GeneProduct ensembl:ENSG00000102755
FLT4 GeneProduct ensembl:ENSG00000037280
NGFR GeneProduct ensembl:ENSG00000064300
TEK GeneProduct ensembl:ENSG00000120156
FLT3 GeneProduct ensembl:ENSG00000122025
NTRK1 GeneProduct ensembl:ENSG00000198400
NTRK2 GeneProduct ensembl:ENSG00000148053 Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:21687
MOB1A GeneProduct ensembl:ENSG00000114978
EFNA1 GeneProduct ensembl:ENSG00000169242
FGF11 GeneProduct ensembl:ENSG00000161958
FGF10 GeneProduct ensembl:ENSG00000070193
EFNA2 GeneProduct ensembl:ENSG00000099617
FGF12 GeneProduct ensembl:ENSG00000114279
ANGPT4 GeneProduct ensembl:ENSG00000101280
ANGPT2 GeneProduct ensembl:ENSG00000091879
ANGPT1 GeneProduct ensembl:ENSG00000154188
EFNA3 GeneProduct ensembl:ENSG00000143590
EFNA4 GeneProduct ensembl:ENSG00000243364
EFNA5 GeneProduct ensembl:ENSG00000184349
FGF14 GeneProduct ensembl:ENSG00000102466
FGF5 GeneProduct ensembl:ENSG00000138675
FGF19 GeneProduct ensembl:ENSG00000162344
FGF17 GeneProduct ensembl:ENSG00000158815
FGF18 GeneProduct ensembl:ENSG00000156427
FGF3 GeneProduct ensembl:ENSG00000186895
FGF4 GeneProduct ensembl:ENSG00000075388
FGF6 GeneProduct ensembl:ENSG00000111241
FGF7 GeneProduct ensembl:ENSG00000140285
FGF8 GeneProduct ensembl:ENSG00000107831
FGF9 GeneProduct ensembl:ENSG00000102678
INS GeneProduct ensembl:ENSG00000254647
FLT3LG GeneProduct ensembl:ENSG00000090554
PGF GeneProduct ensembl:ENSG00000119630
NGF GeneProduct ensembl:ENSG00000134259
FGF21 GeneProduct ensembl:ENSG00000105550
FGF23 GeneProduct ensembl:ENSG00000118972
FGF22 GeneProduct ensembl:ENSG00000070388
FGF20 GeneProduct ensembl:ENSG00000078579
FGF13 GeneProduct ensembl:ENSG00000129682
NTF3 GeneProduct ensembl:ENSG00000185652
NTF4 GeneProduct ensembl:ENSG00000225950
BDNF GeneProduct ensembl:ENSG00000176697
CCL5 GeneProduct ensembl:ENSG00000271503
CD47 GeneProduct ensembl:ENSG00000196776
ACTC1 GeneProduct ensembl:ENSG00000159251
ACTG1 GeneProduct ensembl:ENSG00000184009
ACTG2 GeneProduct ensembl:ENSG00000163017
CTNNA2 GeneProduct ensembl:ENSG00000066032
CTNNA3 GeneProduct ensembl:ENSG00000183230
MOB1B GeneProduct ensembl:ENSG00000173542
TEAD2 GeneProduct ensembl:ENSG00000074219
TEAD3 GeneProduct ensembl:ENSG00000007866
TEAD4 GeneProduct ensembl:ENSG00000197905
STK3 GeneProduct ensembl:ENSG00000104375
MAPK9 GeneProduct ensembl:ENSG00000050748
MAPK10 GeneProduct ensembl:ENSG00000109339
MINK1 GeneProduct ensembl:ENSG00000141503
TNIK GeneProduct ensembl:ENSG00000154310
MAP4K1 GeneProduct ensembl:ENSG00000104814
MAP4K2 GeneProduct ensembl:ENSG00000168067
MAP4K4 GeneProduct ensembl:ENSG00000071054
MAP4K3 GeneProduct ensembl:ENSG00000011566
STK38L GeneProduct ensembl:ENSG00000211455 NDR1/2
NDRG1 GeneProduct ensembl:ENSG00000104419 NDR1/2
FZD3 GeneProduct ensembl:ENSG00000104290
FZD8 GeneProduct ensembl:ENSG00000177283
FZD10 GeneProduct ensembl:ENSG00000111432
FZD7 GeneProduct ensembl:ENSG00000155760
FZD4 GeneProduct ensembl:ENSG00000106483
FZD1 GeneProduct ensembl:ENSG00000157240
FZD6 GeneProduct ensembl:ENSG00000164930
FZD5 GeneProduct ensembl:ENSG00000163251
FZD9 GeneProduct ensembl:ENSG00000188763
FZD2 GeneProduct ensembl:ENSG00000180340
SFRP1 GeneProduct ensembl:ENSG00000104332
SFRP2 GeneProduct ensembl:ENSG00000145423
SFRP4 GeneProduct ensembl:ENSG00000106483
SFRP5 GeneProduct ensembl:ENSG00000120057
WNT3A GeneProduct ensembl:ENSG00000154342
WNT7A GeneProduct ensembl:ENSG00000154764
WNT11 GeneProduct ensembl:ENSG00000085741
WNT1 GeneProduct ensembl:ENSG00000125084
WNT5B GeneProduct ensembl:ENSG00000111186
WNT2 GeneProduct ensembl:ENSG00000105989
WNT2B GeneProduct ensembl:ENSG00000134245
WNT6 GeneProduct ensembl:ENSG00000115596
WNT5A GeneProduct ensembl:ENSG00000114251
WNT16 GeneProduct ensembl:ENSG00000002745
WNT4 GeneProduct ensembl:ENSG00000162552
WNT3 GeneProduct ensembl:ENSG00000108379
WNT10B GeneProduct ensembl:ENSG00000169884
WNT7B GeneProduct ensembl:ENSG00000188064
WNT10A GeneProduct ensembl:ENSG00000135925
ROR1 GeneProduct ensembl:ENSG00000185483
RYK GeneProduct ensembl:ENSG00000163785
ROR2 GeneProduct ensembl:ENSG00000169071
LRP5 GeneProduct ensembl:ENSG00000162337
LRP6 GeneProduct ensembl:ENSG00000070018
KREMEN1 GeneProduct ensembl:ENSG00000183762
FRAT1 GeneProduct ensembl:ENSG00000165879
GSK3B GeneProduct ensembl:ENSG00000082701
CSNK2B GeneProduct ensembl:ENSG00000204435
APC GeneProduct ensembl:ENSG00000134982
CSNK1E GeneProduct ensembl:ENSG00000213923
CTNNB1 GeneProduct ensembl:ENSG00000168036
CSNK1A1 GeneProduct ensembl:ENSG00000113712
CSNK2A1 GeneProduct ensembl:ENSG00000101266
AXIN1 GeneProduct ensembl:ENSG00000103126
CSNK1A1L GeneProduct ensembl:ENSG00000180138
CSNK2A3 GeneProduct ensembl:ENSG00000254598
CSNK2A2 GeneProduct ensembl:ENSG00000070770
FRAT2 GeneProduct ensembl:ENSG00000181274
CXXC4 GeneProduct ensembl:ENSG00000168772
SENP2 GeneProduct ensembl:ENSG00000163904
DVL3 GeneProduct ensembl:ENSG00000161202
DVL2 GeneProduct ensembl:ENSG00000004975
DVL1 GeneProduct ensembl:ENSG00000107404
LEF1 GeneProduct ensembl:ENSG00000138795
TCF7L2 GeneProduct ensembl:ENSG00000148737
CHD8 GeneProduct ensembl:ENSG00000100888
SOX17 GeneProduct ensembl:ENSG00000164736
CTBP1 GeneProduct ensembl:ENSG00000159692
CTBP2 GeneProduct ensembl:ENSG00000175029
PLAU GeneProduct ensembl:ENSG00000122861
JUN GeneProduct ensembl:ENSG00000177606
CCND3 GeneProduct ensembl:ENSG00000112576
FOSL1 GeneProduct ensembl:ENSG00000175592
CCND2 GeneProduct ensembl:ENSG00000118971
PIK3CA GeneProduct ensembl:ENSG00000121879
PIK3CB GeneProduct ensembl:ENSG00000051382
PIK3CD GeneProduct ensembl:ENSG00000171608
RPS6KB1 GeneProduct ensembl:ENSG00000108443
RPS6KB2 GeneProduct ensembl:ENSG00000175634
EIF4B GeneProduct ensembl:ENSG00000063046
RPS6 GeneProduct ensembl:ENSG00000137154
PIK3CG GeneProduct ensembl:ENSG00000105851
AKT1 GeneProduct ensembl:ENSG00000142208
AKT3 GeneProduct ensembl:ENSG00000117020
AKT2 GeneProduct ensembl:ENSG00000105221
MAP2K2 GeneProduct ensembl:ENSG00000126934
MAP2K7 GeneProduct ensembl:ENSG00000076984
MAP2K3 GeneProduct ensembl:ENSG00000034152
MAP3K1 GeneProduct ensembl:ENSG00000095015
MAP3K2 GeneProduct ensembl:ENSG00000169967
MAP3K3 GeneProduct ensembl:ENSG00000198909
MAP3K4 GeneProduct ensembl:ENSG00000085511
MAP3K6 GeneProduct ensembl:ENSG00000142733
MAP3K10 GeneProduct ensembl:ENSG00000130758
MAP3K11 GeneProduct ensembl:ENSG00000173327
MEF2D GeneProduct ensembl:ENSG00000116604
ATF2 GeneProduct ensembl:ENSG00000115966
STAT1 GeneProduct ensembl:ENSG00000115415
CREB1 GeneProduct ensembl:ENSG00000118260
RPS6KA5 GeneProduct ensembl:ENSG00000100784
ELK1 GeneProduct ensembl:ENSG00000126767
HMGN1 GeneProduct ensembl:ENSG00000205581
MKNK2 GeneProduct ensembl:ENSG00000099875
RPS6KA3 GeneProduct ensembl:ENSG00000177189
RPTOR GeneProduct ensembl:ENSG00000141564
CIT GeneProduct ensembl:ENSG00000122966
TNNT1 GeneProduct ensembl:ENSG00000105048
ADAMTS1 GeneProduct ensembl:ENSG00000154734
MAD2L1 GeneProduct ensembl:ENSG00000164109
UHRF1 GeneProduct ensembl:ENSG00000276043
PRSS23 GeneProduct ensembl:ENSG00000150687
KIF23 GeneProduct ensembl:ENSG00000137807
PODXL GeneProduct ensembl:ENSG00000128567
TRAF2 GeneProduct ensembl:ENSG00000127191
MDK GeneProduct ensembl:ENSG00000110492
SELE GeneProduct ensembl:ENSG00000007908
CTHRC1 GeneProduct ensembl:ENSG00000164932
DSC3 GeneProduct ensembl:ENSG00000134762
OGT GeneProduct ensembl:ENSG00000147162
14-3-3 Protein uniprot:A0A0J9YWE8
p14ARF Protein uniprot:Q8N726

References

  1. Biomolecular Pathways and Malignant Pleural Mesothelioma. Jaurand MC, Jean D. In: Malignant Pleural Mesothelioma: Present Status and Future Directions [Internet]. BENTHAM SCIENCE PUBLISHERS; 2016. p. 169–92. Available from: http://dx.doi.org/10.2174/9781681081946116010017 DOI Scholia
  2. Differential motile response of human malignant mesothelioma cells to fibronectin, laminin and collagen type IV: the role of beta1 integrins. Klominek J, Sumitran Karuppan S, Hauzenberger D. Int J Cancer. 1997 Sep 17;72(6):1034–44. PubMed Europe PMC Scholia
  3. The use of CDKN2A deletion as a diagnostic marker for malignant mesothelioma in body cavity effusions. Illei PB, Ladanyi M, Rusch VW, Zakowski MF. Cancer. 2003 Feb 25;99(1):51–6. PubMed Europe PMC Scholia
  4. Regulation of matrix metalloprotease activity in malignant mesothelioma cell lines by growth factors. Liu Z, Klominek J. Thorax. 2003 Mar;58(3):198–203. PubMed Europe PMC Scholia
  5. Matrix metalloproteinases 2 and 9 (gelatinases A and B) expression in malignant mesothelioma and benign pleura. Edwards JG, McLaren J, Jones JL, Waller DA, O’Byrne KJ. Br J Cancer. 2003 May 19;88(10):1553–9. PubMed Europe PMC Scholia
  6. Wnt signaling in disease and in development. Nusse R. Cell Res. 2005 Jan;15(1):28–32. PubMed Europe PMC Scholia
  7. Molecular pathways in malignant pleural mesothelioma. Whitson BA, Kratzke RA. Cancer Lett. 2006 Aug 8;239(2):183–9. PubMed Europe PMC Scholia
  8. Global gene expression profiling of human pleural mesotheliomas: identification of matrix metalloproteinase 14 (MMP-14) as potential tumour target. Crispi S, Calogero RA, Santini M, Mellone P, Vincenzi B, Citro G, et al. PLoS One. 2009 Sep 15;4(9):e7016. PubMed Europe PMC Scholia
  9. An emerging model for BAP1’s role in regulating cell cycle progression. Eletr ZM, Wilkinson KD. Cell Biochem Biophys. 2011 Jun;60(1–2):3–11. PubMed Europe PMC Scholia
  10. New insights into understanding the mechanisms, pathogenesis, and management of malignant mesotheliomas. Mossman BT, Shukla A, Heintz NH, Verschraegen CF, Thomas A, Hassan R. Am J Pathol. 2013 Apr;182(4):1065–77. PubMed Europe PMC Scholia
  11. BAP1 and cancer. Carbone M, Yang H, Pass HI, Krausz T, Testa JR, Gaudino G. Nat Rev Cancer. 2013 Mar;13(3):153–9. PubMed Europe PMC Scholia
  12. Overexpression and promoter mutation of the TERT gene in malignant pleural mesothelioma. Tallet A, Nault JC, Renier A, Hysi I, Galateau-Sallé F, Cazes A, et al. Oncogene. 2014 Jul 10;33(28):3748–52. PubMed Europe PMC Scholia
  13. RASSF tumor suppressor gene family: biological functions and regulation. Volodko N, Gordon M, Salla M, Ghazaleh HA, Baksh S. FEBS Lett. 2014 Aug 19;588(16):2671–84. PubMed Europe PMC Scholia
  14. The ins and outs of fibroblast growth factor receptor signalling. Coleman SJ, Bruce C, Chioni AM, Kocher HM, Grose RP. Clin Sci (Lond). 2014 Aug;127(4):217–31. PubMed Europe PMC Scholia
  15. Reactive oxygen species a double-edged sword for mesothelioma. Benedetti S, Nuvoli B, Catalani S, Galati R. Oncotarget. 2015 Jul 10;6(19):16848–65. PubMed Europe PMC Scholia
  16. Critical review about MDM2 in cancer: Possible role in malignant mesothelioma and implications for treatment. Urso L, Calabrese F, Favaretto A, Conte P, Pasello G. Crit Rev Oncol Hematol. 2016 Jan;97:220–30. PubMed Europe PMC Scholia
  17. The Genetic Landscape of Malignant Pleural Mesothelioma: Results from Massively Parallel Sequencing. Hylebos M, Van Camp G, van Meerbeeck JP, Op de Beeck K. J Thorac Oncol. 2016 Oct;11(10):1615–26. PubMed Europe PMC Scholia
  18. YAP/TAZ at the Roots of Cancer. Zanconato F, Cordenonsi M, Piccolo S. Cancer Cell. 2016 Jun 13;29(6):783–803. PubMed Europe PMC Scholia
  19. Genomic Landscape of Malignant Mesotheliomas. Kato S, Tomson BN, Buys TPH, Elkin SK, Carter JL, Kurzrock R. Mol Cancer Ther. 2016 Oct;15(10):2498–507. PubMed Europe PMC Scholia
  20. Rassf Proteins as Modulators of Mst1 Kinase Activity. Bitra A, Sistla S, Mariam J, Malvi H, Anand R. Sci Rep. 2017 Mar 22;7:45020. PubMed Europe PMC Scholia
  21. BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation. Bononi A, Giorgi C, Patergnani S, Larson D, Verbruggen K, Tanji M, et al. Nature. 2017 Jun 22;546(7659):549–53. PubMed Europe PMC Scholia
  22. Novel insights into mesothelioma biology and implications for therapy. Yap TA, Aerts JG, Popat S, Fennell DA. Nat Rev Cancer. 2017 Jul 25;17(8):475–88. PubMed Europe PMC Scholia
  23. Large-scale copy number analysis reveals variations in genes not previously associated with malignant pleural mesothelioma. Hylebos M, Van Camp G, Vandeweyer G, Fransen E, Beyens M, Cornelissen R, et al. Oncotarget. 2017 Dec 1;8(69):113673–86. PubMed Europe PMC Scholia
  24. Targeting the Hippo Pathway Is a New Potential Therapeutic Modality for Malignant Mesothelioma. Sekido Y. Cancers (Basel). 2018 Mar 22;10(4):90. PubMed Europe PMC Scholia
  25. The hippo pathway provides novel insights into lung cancer and mesothelioma treatment. Liu XL, Zuo R, Ou WB. J Cancer Res Clin Oncol. 2018 Nov;144(11):2097–106. PubMed Europe PMC Scholia
  26. Mechanoregulation and pathology of YAP/TAZ via Hippo and non-Hippo mechanisms. Dobrokhotov O, Samsonov M, Sokabe M, Hirata H. Clin Transl Med. 2018 Aug 13;7(1):23. PubMed Europe PMC Scholia
  27. Molecular pathways and diagnosis in malignant mesothelioma: A review of the 14th International Conference of the International Mesothelioma Interest Group. Chapel DB, Churg A, Santoni-Rugiu E, Tsujimura T, Hiroshima K, Husain AN. Lung Cancer. 2019 Jan;127:69–75. PubMed Europe PMC Scholia
  28. Mesothelioma: Scientific clues for prevention, diagnosis, and therapy. Carbone M, Adusumilli PS, Alexander HR Jr, Baas P, Bardelli F, Bononi A, et al. CA Cancer J Clin. 2019 Sep;69(5):402–29. PubMed Europe PMC Scholia
  29. Mechanisms underlying the activation of TERT transcription and telomerase activity in human cancer: old actors and new players. Yuan X, Larsson C, Xu D. Oncogene. 2019 Aug;38(34):6172–83. PubMed Europe PMC Scholia
  30. The Immune Microenvironment in Mesothelioma: Mechanisms of Resistance to Immunotherapy. Chu GJ, van Zandwijk N, Rasko JEJ. Front Oncol. 2019 Dec 6;9:1366. PubMed Europe PMC Scholia
  31. Telomerase Reverse Transcriptase Promoter Mutations Identify a Genomically Defined and Highly Aggressive Human Pleural Mesothelioma Subgroup. Pirker C, Bilecz A, Grusch M, Mohr T, Heidenreich B, Laszlo V, et al. Clin Cancer Res. 2020 Jul 15;26(14):3819–30. PubMed Europe PMC Scholia
  32. TERT promoter mutations and GABP transcription factors in carcinogenesis: More foes than friends. Yuan X, Dai M, Xu D. Cancer Lett. 2020 Nov 28;493:1–9. PubMed Europe PMC Scholia
  33. Genomics and Functional Genomics of Malignant Pleural Mesothelioma. Cakiroglu E, Senturk S. Int J Mol Sci. 2020 Sep 1;21(17):6342. PubMed Europe PMC Scholia
  34. Fundamental insights into the interaction between telomerase/TERT and intracellular signaling pathways. Ghareghomi S, Ahmadian S, Zarghami N, Kahroba H. Biochimie. 2021 Feb;181:12–24. PubMed Europe PMC Scholia
  35. TERT-Regulation and Roles in Cancer Formation. Dratwa M, Wysoczańska B, Łacina P, Kubik T, Bogunia-Kubik K. Front Immunol. 2020 Nov 19;11:589929. PubMed Europe PMC Scholia
  36. Roles and mechanisms of BAP1 deubiquitinase in tumor suppression. Masclef L, Ahmed O, Estavoyer B, Larrivée B, Labrecque N, Nijnik A, et al. Cell Death Differ. 2021 Feb;28(2):606–25. PubMed Europe PMC Scholia
  37. Identification of Overexpressed Genes in Malignant Pleural Mesothelioma. Morani F, Bisceglia L, Rosini G, Mutti L, Melaiu O, Landi S, et al. Int J Mol Sci. 2021 Mar 8;22(5):2738. PubMed Europe PMC Scholia
  38. Pathological Characterization of Tumor Immune Microenvironment (TIME) in Malignant Pleural Mesothelioma. Napoli F, Listì A, Zambelli V, Witel G, Bironzo P, Papotti M, et al. Cancers (Basel). 2021 May 24;13(11):2564. PubMed Europe PMC Scholia
  39. Biological basis for novel mesothelioma therapies. Obacz J, Yung H, Shamseddin M, Linnane E, Liu X, Azad AA, et al. Br J Cancer. 2021 Oct;125(8):1039–55. PubMed Europe PMC Scholia