Neuroinflammation and glutamatergic signaling (WP5083)

Homo sapiens

The relation between neuroinflammation and glutamatergic signaling

Authors

Lisa Koole , Friederike Ehrhart , Lauren J. Dupuis , Eric Weitz , Finterly Hu , and Egon Willighagen

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Serious Request 2024 - MetaKids

Annotations

Pathway Ontology

signaling pathway pertinent to immunity neuropsychiatric disease pathway signaling pathway pertinent to the brain and nervous system

Cell Type Ontology

microglial cell astrocyte glial cell neuron

Participants

Label Type Compact URI Comment
superoxide Metabolite chebi:18421
NH3(+) Metabolite chebi:29421
LPS Metabolite chebi:16412
H2O2 Metabolite chebi:16240
nitric oxide Metabolite chebi:16480
Acetyl-CoA Metabolite chebi:15351
glutamate Metabolite chebi:14321
L-Aspartate Metabolite chebi:17053
PHP Metabolite chebi:18110
PP3 Metabolite wikidata:Q27088431
glutamine Metabolite chebi:28300
2-oxoglutarate Metabolite chebi:16810
Mg2+ Metabolite chebi:18420
L-serine Metabolite chebi:17115
H+ Metabolite chebi:15378
D-serine Metabolite chebi:35247
cAMP Metabolite chebi:17489
1,3-diglycerides Metabolite chebi:47777
Glycine Metabolite chebi:15428
3PG Metabolite chebi:17138
1,2-diglycerides Metabolite chebi:49172
3-Phosphoserine Metabolite chebi:37712
pyruvate Metabolite chebi:15361
NAD+ Metabolite chebi:15846
Ca2+ Metabolite chebi:29108
2-ketoglutarate Metabolite chebi:16810
NADH Metabolite chebi:16908
glucose Metabolite chebi:17234
IL13RA1 GeneProduct ncbigene:3597
NFKB2 GeneProduct ncbigene:4791
IL1R2 GeneProduct ncbigene:7850
LIF GeneProduct ncbigene:3976
TRAF5 GeneProduct ncbigene:7188
IL4 GeneProduct ncbigene:3565
TNFRSF1B GeneProduct ncbigene:7133
IL4R GeneProduct ncbigene:3566
GFAP GeneProduct ncbigene:2670
IL6 GeneProduct ncbigene:3569
SMAD2 GeneProduct ncbigene:4087
NGF GeneProduct ncbigene:4803
IL1A GeneProduct ncbigene:3552
IL6ST GeneProduct ncbigene:3572
IFNG GeneProduct ncbigene:3458
TGFBR2 GeneProduct ncbigene:7048
STAT3 GeneProduct ncbigene:6774
TNFRSF1A GeneProduct ncbigene:7132
BDNF GeneProduct ncbigene:627
TGFB1 GeneProduct ncbigene:7040
LTA GeneProduct ncbigene:4049
IL13 GeneProduct ncbigene:3596
IL10RB GeneProduct ncbigene:3588
JAK1 GeneProduct ncbigene:3716
STAT1 GeneProduct ncbigene:6772
TGFBR3 GeneProduct ncbigene:7049
DAO GeneProduct ncbigene:1610
IL12A GeneProduct ncbigene:3592
SOCS3 GeneProduct ncbigene:9021
STAT6 GeneProduct ncbigene:6778
IL10RA GeneProduct ncbigene:3587
IRS1 GeneProduct ncbigene:3667
AKT1 GeneProduct ncbigene:207
TGFB2 GeneProduct ncbigene:7042
IL6R GeneProduct ncbigene:3570
SMAD3 GeneProduct ncbigene:4088
IL1R1 GeneProduct ncbigene:3554
TGFBR1 GeneProduct ncbigene:7046
SMAD7 GeneProduct ncbigene:4092
INSR GeneProduct ncbigene:3643
IL12B GeneProduct ncbigene:3593
FGF2 GeneProduct ncbigene:2247
NOS1 GeneProduct ncbigene:4842
TGFB3 GeneProduct ncbigene:7043
IL1B GeneProduct ncbigene:3553
SMAD4 GeneProduct ncbigene:4089
NFKB1 GeneProduct ncbigene:4790
GRIN1 GeneProduct ncbigene:2902
GRM8 GeneProduct ncbigene:2918
GRIK4 GeneProduct ncbigene:2900
GRIN2A GeneProduct ncbigene:2903
GRIK3 GeneProduct ncbigene:2899
PPP1CC GeneProduct ncbigene:5501
GRIN2D GeneProduct ncbigene:2906
GRIK5 GeneProduct ncbigene:2901
GRM7 GeneProduct ncbigene:2917
CAMKK2 GeneProduct ncbigene:10645
MAPK1 GeneProduct ncbigene:5594
SHMT1 GeneProduct ncbigene:6470
CAMK4 GeneProduct ncbigene:814
PHGDH GeneProduct ncbigene:26227
GOT1 GeneProduct ncbigene:2805
CAMK2A GeneProduct ncbigene:815
LRRC8B GeneProduct ncbigene:23507
LRRC8E GeneProduct ncbigene:80131
LRRC8A GeneProduct ncbigene:56262
SRR GeneProduct ncbigene:63826
GRIN2C GeneProduct ncbigene:2905
SLC1A4 GeneProduct ncbigene:6509
GRIA3 GeneProduct ncbigene:2892
PSPH GeneProduct ncbigene:5723
GRIA4 GeneProduct ncbigene:2893
GRIK2 GeneProduct ncbigene:2898
GRIA2 GeneProduct ncbigene:2891
GRM4 GeneProduct ncbigene:2914
GRIN3B GeneProduct ncbigene:116444
PLCB2 GeneProduct ncbigene:5330
PRKACA GeneProduct ncbigene:5566
PRKCG GeneProduct ncbigene:5582
ADCY1 GeneProduct ncbigene:107
LRRC8D GeneProduct ncbigene:55144
PSAT1 GeneProduct ncbigene:29968
PRKCB GeneProduct ncbigene:5579
PLCB1 GeneProduct ncbigene:23236
PPP1CB GeneProduct ncbigene:5500
SLC38A1 GeneProduct ncbigene:81539
SLC6A9 GeneProduct ncbigene:6536
CAMK2G GeneProduct ncbigene:818
PDHA1 GeneProduct ncbigene:5160
GRM1 GeneProduct ncbigene:2911
ADCY3 GeneProduct ncbigene:109
PRKCA GeneProduct ncbigene:5578
MAPK3 GeneProduct ncbigene:5595
CAMKK1 GeneProduct ncbigene:84254
PLCB3 GeneProduct ncbigene:5331
PPP1CA GeneProduct ncbigene:5499
NSMF GeneProduct ncbigene:26012 Synonym: Jacob
GRIN2B GeneProduct ncbigene:2904
SLC1A6 GeneProduct ncbigene:6511
SHMT2 GeneProduct ncbigene:6472
DLAT GeneProduct ncbigene:1737
DLD GeneProduct ncbigene:1738
ADCY8 GeneProduct ncbigene:114
DISC1 GeneProduct ncbigene:27185
LRRC8C GeneProduct ncbigene:84230
SLC38A2 GeneProduct ncbigene:54407
CFL1 GeneProduct ncbigene:1072
TRPM4 GeneProduct ncbigene:54795
PLCB4 GeneProduct ncbigene:5332
CAMK2B GeneProduct ncbigene:816
GRM2 GeneProduct ncbigene:2912
GRIK1 GeneProduct ncbigene:2897
CAMK2D GeneProduct ncbigene:817
GRIA1 GeneProduct ncbigene:2890
SLC1A1 GeneProduct ncbigene:6505
CALM1 GeneProduct ncbigene:801
GRIN3A GeneProduct ncbigene:116443
GLS GeneProduct ncbigene:2744
GLS2 GeneProduct ncbigene:27165
SLC17A6 GeneProduct ncbigene:57084
SLC17A7 GeneProduct ncbigene:57030
SLC38A5 GeneProduct ncbigene:92745
SLC38A3 GeneProduct ncbigene:10991
GRM5 GeneProduct ncbigene:2915
SLC7A10 GeneProduct ncbigene:56301
SLC2A1 GeneProduct ncbigene:6513
SLC2A3 GeneProduct ncbigene:6515
CNTF GeneProduct ncbigene:1270
TNF GeneProduct ncbigene:7124
IL10 GeneProduct ncbigene:3586
IGF1 GeneProduct ncbigene:3479
SLC1A2 GeneProduct ncbigene:6506
SLC1A3 GeneProduct ncbigene:6507
IFNGR2 GeneProduct ncbigene:3460
IFNGR1 GeneProduct ncbigene:3459
CREB1 GeneProduct ncbigene:1385
ARC GeneProduct ncbigene:23237
BCL2 GeneProduct ncbigene:596
FOS GeneProduct ncbigene:2353
GS Protein uniprot:P15104

References

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