FOXA2 pathway (WP5066)

Homo sapiens

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Role of Foxa2

Authors

Chesley De Windt , Egon Willighagen , Friederike Ehrhart , Kristina Hanspers , and Eric Weitz

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

Annotations

Pathway Ontology

regulatory pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
TAGs Metabolite chebi:17855
IRS2 GeneProduct ensembl:ENSG00000185950
FOXA2 GeneProduct ensembl:ENSG00000125798
PPARGC1B GeneProduct ensembl:ENSG00000155846
FASN GeneProduct ensembl:ENSG00000169710
GSTA1 GeneProduct ensembl:ENSG00000243955
IRS1 GeneProduct ensembl:ENSG00000169047
ABCC4 GeneProduct ensembl:ENSG00000125257
ABCC3 GeneProduct ensembl:ENSG00000108846
ABCC2 GeneProduct ensembl:ENSG00000023839
SLC27A5 GeneProduct ensembl:ENSG00000083807
SLCO1B1 GeneProduct ensembl:ENSG00000134538
FOXO1 GeneProduct ensembl:ENSG00000150907
GSTA2 GeneProduct ensembl:ENSG00000244067
FOXA1 GeneProduct ensembl:ENSG00000129514
GSTM2 GeneProduct ensembl:ENSG00000213366
MTTP GeneProduct ensembl:ENSG00000138823
Apolipoprotein B-100 Protein uniprot:P04114
Acetyl-CoA carboxylase 1 Protein uniprot:Q13085
ChREBP Protein uniprot:Q9NP71
SREBP-1c Protein uniprot:P36956
Insulin Protein uniprot:A6XGL2

References

  1. Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis. Horton JD. Biochem Soc Trans. 2002 Nov;30(Pt 6):1091–5. PubMed Europe PMC Scholia
  2. Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization. Wolfrum C, Besser D, Luca E, Stoffel M. Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11624–9. PubMed Europe PMC Scholia
  3. Coactivation of Foxa2 through Pgc-1beta promotes liver fatty acid oxidation and triglyceride/VLDL secretion. Wolfrum C, Stoffel M. Cell Metab. 2006 Feb;3(2):99–110. PubMed Europe PMC Scholia
  4. Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress. Bochkis IM, Rubins NE, White P, Furth EE, Friedman JR, Kaestner KH. Nat Med. 2008 Aug;14(8):828–36. PubMed Europe PMC Scholia
  5. Foxa1 and Foxa2 maintain the metabolic and secretory features of the mature beta-cell. Gao N, Le Lay J, Qin W, Doliba N, Schug J, Fox AJ, et al. Mol Endocrinol. 2010 Aug;24(8):1594–604. PubMed Europe PMC Scholia