Angiotensin II receptor type 1 pathway (WP5036)

Homo sapiens

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Angiotensin II binds its type-1 receptor (AGTR1) triggering distinct pathways in various cell types. Here the pathways in lung fibroblasts, lung vascular smooth muscle cells, and alveolar epithelium are detailed.

For a description of pathway objects, see the WikiPathways Legend.

Authors

Marvin Martens , Kristina Hanspers , Stefan Raats , Eric Weitz , Egon Willighagen , Alex Pico , and Daniela Digles

Activity

last edited

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Cited In

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Organisms

Homo sapiens

Communities

ONTOX

Annotations

Cell Type Ontology

smooth muscle cell epithelial cell fibroblast of lung vascular associated smooth muscle cell

Pathway Ontology

angiotensin II signaling pathway signaling pathway

Participants
Query Drugst.One

Label Type Compact URI Comment
Ang 1-7 Metabolite chebi:55438
Angiotensin II Metabolite chebi:58506
TGFBR1 GeneProduct ensembl:ENSG00000106799
NOX4 GeneProduct ncbigene:50507
MKK GeneProduct ensembl:ENSG00000108984
MAPK1 GeneProduct ensembl:ENSG00000100030
MAS1 GeneProduct ensembl:ENSG00000130368
TGFBR2 GeneProduct ensembl:ENSG00000163513
RACK1 GeneProduct ensembl:ENSG00000204628
Ras GeneProduct ensembl:ENSG00000126458
RAF GeneProduct ensembl:ENSG00000132155
SMAD4 GeneProduct ensembl:ENSG00000141646
PDGFD GeneProduct ensembl:ENSG00000170962
IL11RA GeneProduct ensembl:ENSG00000137070
ACTA2 GeneProduct ensembl:ENSG00000107796
SP1 GeneProduct ensembl:ENSG00000185591
AGTR1 GeneProduct ensembl:ENSG00000144891
SMAD3 GeneProduct ensembl:ENSG00000166949
JUND GeneProduct ensembl:ENSG00000130522
IL11 GeneProduct ensembl:ENSG00000095752
CTGF GeneProduct ensembl:ENSG00000118523
F12 GeneProduct ensembl:ENSG00000131187
HIF1A GeneProduct ensembl:ENSG00000100644
TGFB1 GeneProduct ensembl:ENSG00000105329
IL6ST GeneProduct ensembl:ENSG00000134352
PTPN11 GeneProduct ensembl:ENSG00000179295
COL1A1 GeneProduct ensembl:ENSG00000108821
COL1A2 GeneProduct ensembl:ENSG00000164692
ACE2 Protein uniprot:Q9BYF1
Angiotensinogen Protein uniprot:P01019

References

  1. Cytokines and pulmonary fibrosis. Zhang K, Phan SH. Biol Signals. 1996;5(4):232–9. PubMed Europe PMC Scholia
  2. Angiotensin II stimulates collagen synthesis in human vascular smooth muscle cells. Involvement of the AT(1) receptor, transforming growth factor-beta, and tyrosine phosphorylation. Ford CM, Li S, Pickering JG. Arterioscler Thromb Vasc Biol. 1999 Aug;19(8):1843–51. PubMed Europe PMC Scholia
  3. RACK1 mediates activation of JNK by protein kinase C [corrected]. López-Bergami P, Habelhah H, Bhoumik A, Zhang W, Wang LH, Ronai Z. Mol Cell. 2005 Aug 5;19(3):309–20. PubMed Europe PMC Scholia
  4. Emerging evidence for a functional angiotensin-converting enzyme 2-angiotensin-(1-7)-MAS receptor axis: more than regulation of blood pressure? Chappell MC. Hypertension. 2007 Oct;50(4):596–9. PubMed Europe PMC Scholia
  5. Dual role of collagen in factor XII-dependent thrombus formation. van der Meijden PEJ, Munnix ICA, Auger JM, Govers-Riemslag JWP, Cosemans JMEM, Kuijpers MJE, et al. Blood. 2009 Jul 23;114(4):881–90. PubMed Europe PMC Scholia
  6. Angiotensin signalling in pulmonary fibrosis. Uhal BD, Li X, Piasecki CC, Molina-Molina M. Int J Biochem Cell Biol. 2012 Mar;44(3):465–8. PubMed Europe PMC Scholia
  7. Interleukin-11 signaling underlies fibrosis, parenchymal dysfunction, and chronic inflammation of the airway. Ng B, Cook SA, Schafer S. Exp Mol Med. 2020 Dec;52(12):1871–8. PubMed Europe PMC Scholia